Joseph M Braun1, Nan Li2, Tye E Arbuckle3, Linda Dodds4, Isabelle Massarelli5, William D Fraser6, Bruce P Lanphear7, Gina Muckle8. 1. Department of Epidemiology, Brown University, Providence, RI, United States. Electronic address: joseph_braun_1@brown.edu. 2. Department of Epidemiology, Brown University, Providence, RI, United States. 3. Population Studies Division, Environmental Health Science and Research Bureau, Health Canada, Ottawa, Canada. 4. Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. 5. Surveillance Integration, Health Canada, Ottawa, Canada. 6. Centre for Research of CHUS, University of Sherbrooke, Sherbrooke, Canada; Quebec CHU Laval University Research Center, Quebec, Canada. 7. Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada; BC Children's Hospital Research Institute, Vancouver, Canada. 8. School of Psychology, Laval University, Quebec CHU-Laval University Research Center, Quebec City, Canada.
Abstract
BACKGROUND: Bisphenol A (BPA) is a high production volume chemical and because of its use in many consumer products, exposure is ubiquitous. Gestational BPA exposure has been associated with excess adiposity in rodent studies, but not consistently in human studies. We investigated the relation between gestational BPA exposure and early childhood adiposity in a prospective cohort study of 719 mother-child pairs. METHODS: We used data from the MIREC Study, a prospective Pan-Canadian pregnancy and birth cohort study. We measured BPA in urine samples collected at an average of 12.1 weeks (range: 6.3-15 weeks) gestation and measured children's weight, height, waist/hip circumference, and subscapular/triceps skinfold thickness at an average age of 3.5 years (range: 1.9-6.2). We estimated covariate-adjusted associations of log2-transformed BPA concentrations with child adiposity measures and examined whether these associations differed in boys and girls. RESULTS: Median BPA concentrations were 0.8 ng/mL (IQR: 0.5-1.4). Among both boys and girls, each 2-fold increase in BPA concentrations was associated with higher waist-to-hip ratio (β: 0.003; 95% CI: 0.001, 0.005). The association of BPA with waist circumference and subscapular skinfold thickness was modified by sex (sex x BPA interaction p-values<0.2). In girls, each 2-fold increase in BPA concentrations was associated with a 0.2 cm (95% CI: 0.0, 0.5) and 0.15 mm (95% CI: 0.01, 0.30) increase in waist circumference and subscapular skinfolds, respectively. Associations were generally null or slightly inverse in boys. CONCLUSIONS: In this cohort, gestational urinary BPA concentrations were associated with subtle increases in girl's central adiposity during early childhood.
BACKGROUND:Bisphenol A (BPA) is a high production volume chemical and because of its use in many consumer products, exposure is ubiquitous. Gestational BPA exposure has been associated with excess adiposity in rodent studies, but not consistently in human studies. We investigated the relation between gestational BPA exposure and early childhood adiposity in a prospective cohort study of 719 mother-child pairs. METHODS: We used data from the MIREC Study, a prospective Pan-Canadian pregnancy and birth cohort study. We measured BPA in urine samples collected at an average of 12.1 weeks (range: 6.3-15 weeks) gestation and measured children's weight, height, waist/hip circumference, and subscapular/triceps skinfold thickness at an average age of 3.5 years (range: 1.9-6.2). We estimated covariate-adjusted associations of log2-transformed BPA concentrations with child adiposity measures and examined whether these associations differed in boys and girls. RESULTS: Median BPA concentrations were 0.8 ng/mL (IQR: 0.5-1.4). Among both boys and girls, each 2-fold increase in BPA concentrations was associated with higher waist-to-hip ratio (β: 0.003; 95% CI: 0.001, 0.005). The association of BPA with waist circumference and subscapular skinfold thickness was modified by sex (sex x BPA interaction p-values<0.2). In girls, each 2-fold increase in BPA concentrations was associated with a 0.2 cm (95% CI: 0.0, 0.5) and 0.15 mm (95% CI: 0.01, 0.30) increase in waist circumference and subscapular skinfolds, respectively. Associations were generally null or slightly inverse in boys. CONCLUSIONS: In this cohort, gestational urinary BPA concentrations were associated with subtle increases in girl's central adiposity during early childhood.
Authors: Richard J Santen; D Craig Allred; Stacy P Ardoin; David F Archer; Norman Boyd; Glenn D Braunstein; Henry G Burger; Graham A Colditz; Susan R Davis; Marco Gambacciani; Barbara A Gower; Victor W Henderson; Wael N Jarjour; Richard H Karas; Michael Kleerekoper; Roger A Lobo; JoAnn E Manson; Jo Marsden; Kathryn A Martin; Lisa Martin; JoAnn V Pinkerton; David R Rubinow; Helena Teede; Diane M Thiboutot; Wulf H Utian Journal: J Clin Endocrinol Metab Date: 2010-06-21 Impact factor: 5.958
Authors: Kristina A Thayer; Daniel R Doerge; Dawn Hunt; Shepherd H Schurman; Nathan C Twaddle; Mona I Churchwell; Stavros Garantziotis; Grace E Kissling; Michael R Easterling; John R Bucher; Linda S Birnbaum Journal: Environ Int Date: 2015-06-24 Impact factor: 9.621
Authors: Tiffany C Yang; Karen E Peterson; John D Meeker; Brisa N Sánchez; Zhenzhen Zhang; Alejandra Cantoral; Maritsa Solano; Martha M Tellez-Rojo Journal: Environ Res Date: 2017-04-05 Impact factor: 6.498
Authors: Robert M Sargis; Daniel N Johnson; Rashikh A Choudhury; Matthew J Brady Journal: Obesity (Silver Spring) Date: 2009-11-19 Impact factor: 5.002
Authors: Kyla W Taylor; Bonnie R Joubert; Joe M Braun; Caroline Dilworth; Chris Gennings; Russ Hauser; Jerry J Heindel; Cynthia V Rider; Thomas F Webster; Danielle J Carlin Journal: Environ Health Perspect Date: 2016-12-01 Impact factor: 9.031
Authors: Jerrold J Heindel; Sarah Howard; Keren Agay-Shay; Juan P Arrebola; Karine Audouze; Patrick J Babin; Robert Barouki; Amita Bansal; Etienne Blanc; Matthew C Cave; Saurabh Chatterjee; Nicolas Chevalier; Mahua Choudhury; David Collier; Lisa Connolly; Xavier Coumoul; Gabriella Garruti; Michael Gilbertson; Lori A Hoepner; Alison C Holloway; George Howell; Christopher D Kassotis; Mathew K Kay; Min Ji Kim; Dominique Lagadic-Gossmann; Sophie Langouet; Antoine Legrand; Zhuorui Li; Helene Le Mentec; Lars Lind; P Monica Lind; Robert H Lustig; Corinne Martin-Chouly; Vesna Munic Kos; Normand Podechard; Troy A Roepke; Robert M Sargis; Anne Starling; Craig R Tomlinson; Charbel Touma; Jan Vondracek; Frederick Vom Saal; Bruce Blumberg Journal: Biochem Pharmacol Date: 2022-04-05 Impact factor: 6.100
Authors: Leonardo Trasande; Vincent W V Jaddoe; Chalana M Sol; Susana Santos; Liesbeth Duijts; Alexandros G Asimakopoulos; Maria-Pilar Martinez-Moral; Kurunthachalam Kannan; Elise M Philips Journal: Int J Obes (Lond) Date: 2020-09-12 Impact factor: 5.095