Magdalena Janecka1, Stefan N Hansen2, Amirhossein Modabbernia3, Heidi A Browne4, Joseph D Buxbaum5, Diana E Schendel6, Abraham Reichenberg7, Erik T Parner2, Dorothy E Grice8. 1. Icahn School of Medicine at Mount Sinai, New York, NY; Seaver Autism Center for Research and Treatment. 2. Aarhus University. 3. Icahn School of Medicine at Mount Sinai, New York, NY. 4. Icahn School of Medicine at Mount Sinai, New York, NY; Icahn School of Medicine at Mount Sinai, Division of Tics, OCD, and Related Disorders. 5. Icahn School of Medicine at Mount Sinai, New York, NY; Seaver Autism Center for Research and Treatment; Friedman Brain Institute and Mindich Child Health and Development Institute. 6. Section for Epidemiology, the National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark; Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus. 7. Icahn School of Medicine at Mount Sinai, New York, NY; Seaver Autism Center for Research and Treatment; Friedman Brain Institute and Mindich Child Health and Development Institute; Institute for Translational Epidemiology. 8. Icahn School of Medicine at Mount Sinai, New York, NY; Icahn School of Medicine at Mount Sinai, Division of Tics, OCD, and Related Disorders; Friedman Brain Institute and Mindich Child Health and Development Institute. Electronic address: Dorothy.Grice@mssm.edu.
Abstract
OBJECTIVE: Parental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. A population-based cohort was used to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and Tourette's disorder/chronic tic disorder (TD/CT). METHOD: The study cohort included all singleton births in Denmark from 1980 through 2007 with full information on parental ages (N = 1,490,745) and was followed through December 31, 2013. Cases of ASD, ADHD, OCD, and TD/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time. RESULTS: Younger parental age was significantly associated with increased estimates of risk for ADHD and TD/CT, whereas older parental age was associated with ASD and OCD. Except for OCD, no evidence for differential effects of parental ages on male versus female offspring was observed. CONCLUSION: This study provides novel evidence for the association between age at parenthood and TD/CT and OCD and for the first time shows in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. These results are consistent with a model of shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.
OBJECTIVE: Parental age at birth has been shown to affect the rates of a range of neurodevelopmental disorders, but the understanding of the mechanisms through which it mediates different outcomes is still lacking. A population-based cohort was used to assess differential effects of parental age on estimates of risk across pediatric-onset neuropsychiatric disorders: autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), and Tourette's disorder/chronic tic disorder (TD/CT). METHOD: The study cohort included all singleton births in Denmark from 1980 through 2007 with full information on parental ages (N = 1,490,745) and was followed through December 31, 2013. Cases of ASD, ADHD, OCD, and TD/CT were identified in the Danish Psychiatric Central Register and the National Patient Register. Associations with parental age were modeled using a stratified Cox regression, allowing for changes in baseline diagnostic rates across time. RESULTS: Younger parental age was significantly associated with increased estimates of risk for ADHD and TD/CT, whereas older parental age was associated with ASD and OCD. Except for OCD, no evidence for differential effects of parental ages on male versus female offspring was observed. CONCLUSION: This study provides novel evidence for the association between age at parenthood and TD/CT and OCD and for the first time shows in a population-based sample that parental age confers differential risk rates for pediatric-onset psychiatric disorders. These results are consistent with a model of shared and unshared risk architecture for pediatric-onset neuropsychiatric conditions, highlighting unique contributions of maternal and paternal ages.
Authors: Arad Kodesh; Stephen Z Levine; Vahe Khachadourian; Rayees Rahman; Avner Schlessinger; Paul F O'Reilly; Jakob Grove; Diana Schendel; Joseph D Buxbaum; Lisa Croen; Abraham Reichenberg; Sven Sandin; Magdalena Janecka Journal: Psychol Med Date: 2021-03-26 Impact factor: 10.592
Authors: Kristen Lyall; Lanxin Song; Kelly Botteron; Lisa A Croen; Stephen R Dager; M Daniele Fallin; Heather C Hazlett; Elizabeth Kauffman; Rebecca Landa; Christine Ladd-Acosta; Daniel S Messinger; Sally Ozonoff; Juhi Pandey; Joseph Piven; Rebecca J Schmidt; Robert T Schultz; Wendy L Stone; Craig J Newschaffer; Heather E Volk Journal: Autism Res Date: 2020-04-21 Impact factor: 4.633