Magdalena Niestrata-Ortiz1, Piotr Fichna2, Witold Stankiewicz2, Marcin Stopa3. 1. Western Eye Hospital, Ophthalmology, 153-173 Marylebone Road, London, NW1 5QT, UK. magdalena.niestrata@doctors.org.uk. 2. Department of Paediatric Diabetes and Obesity, Poznan University of Medical Sciences, 27/33 Szpitalna Street, 60-572, Poznan, Poland. 3. Department of Ophthalmology, Chair of Ophthalmology and Optometry. Heliodor Swiecicki University Hospital, Poznan University of Medical Sciences, 16/18 Grunwaldzka Street, 60-780, Poznan, Poland.
Abstract
PURPOSE: Evaluation of foveal avascular zone (FAZ) in children with diabetes (DM) using OCTA. METHODS: We examined 112 diabetic children without DR aged 6-18 years and 30 age-matched controls using Topcon OCT Angiography and measured FAZ in superficial (SCP) and deep capillary plexus (DCP). The study group was divided into three subgroups depending on DM duration group 1: < 5 years (n = 40), group 2: 5-10 years (n = 42), group 3: > 10 years (n = 30). RESULTS: The mean DCP FAZ increased with DM duration from 502.2 μm2 (SD 137.8) in group 1 to 523.9 μm2 (SD 159.2) in group 2 and 539.7 μm2 (SD 189.1) in group 3. Control group differed significantly from group 1 (p = 0.0120), group 2 (p = 0.0019) and group 3 (p = 0.0011). The mean DCP to SCP FAZ surface ratio was 1.88 (SD 0.68) in the study vs 1.58 (SD 0.48) in the control group (p = 0.0232). The DCP and SCP FAZ surface difference was 217.6 μm2 (SD 100.8 μm2) in diabetics vs. 124.2 μm2 (SD 72.8 μm2) in controls (p < 0.0001). In the control group, it was significantly smaller than in group 1 (p < 0.006), group 2 (p < 0.0001) and group 3 (p < 0.0001). CONCLUSIONS: Changes can be detected in FAZ of diabetic children before DR development which can be vital for screening.
PURPOSE: Evaluation of foveal avascular zone (FAZ) in children with diabetes (DM) using OCTA. METHODS: We examined 112 diabeticchildren without DR aged 6-18 years and 30 age-matched controls using Topcon OCT Angiography and measured FAZ in superficial (SCP) and deep capillary plexus (DCP). The study group was divided into three subgroups depending on DM duration group 1: < 5 years (n = 40), group 2: 5-10 years (n = 42), group 3: > 10 years (n = 30). RESULTS: The mean DCPFAZ increased with DM duration from 502.2 μm2 (SD 137.8) in group 1 to 523.9 μm2 (SD 159.2) in group 2 and 539.7 μm2 (SD 189.1) in group 3. Control group differed significantly from group 1 (p = 0.0120), group 2 (p = 0.0019) and group 3 (p = 0.0011). The mean DCP to SCPFAZ surface ratio was 1.88 (SD 0.68) in the study vs 1.58 (SD 0.48) in the control group (p = 0.0232). The DCP and SCPFAZ surface difference was 217.6 μm2 (SD 100.8 μm2) in diabetics vs. 124.2 μm2 (SD 72.8 μm2) in controls (p < 0.0001). In the control group, it was significantly smaller than in group 1 (p < 0.006), group 2 (p < 0.0001) and group 3 (p < 0.0001). CONCLUSIONS: Changes can be detected in FAZ of diabeticchildren before DR development which can be vital for screening.
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