Literature DB >> 30824572

Seeing is believing: DNA zipping promotes DNA repair.

Petr Cejka1.   

Abstract

DNA double-strand break repair by homologous recombination is initiated by the Ctp1 protein together with the Mre11-Rad50-Nbs1 nuclease complex in Schizosaccharomyces pombe, but the mechanism by which Ctp1 promotes this process has remained unknown. Andres et al. now use atomic force microscopy to image Ctp1-DNA complexes, demonstrating a striking capacity of Ctp1 filaments to bridge DNA molecules. This unanticipated role of Ctp1 might help explain how the processing of DNA ends is coordinated to facilitate DNA break repair.
© 2019 Cejka.

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Year:  2019        PMID： 30824572      PMCID： PMC6398134          DOI： 10.1074/jbc.H119.007814

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  10 in total

1.  Ctp1 protein-DNA filaments promote DNA bridging and DNA double-strand break repair.

Authors:  Sara N Andres; Zimeng M Li; Dorothy A Erie; R Scott Williams
Journal:  J Biol Chem       Date:  2019-01-09       Impact factor: 5.157

2.  Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks.

Authors:  Elda Cannavo; Petr Cejka
Journal:  Nature       Date:  2014-09-17       Impact factor: 49.962

3.  Human Rad50/Mre11 is a flexible complex that can tether DNA ends.

Authors:  M de Jager; J van Noort; D C van Gent; C Dekker; R Kanaar; C Wyman
Journal:  Mol Cell       Date:  2001-11       Impact factor: 17.970

4.  High affinity cooperative DNA binding by the yeast Mlh1-Pms1 heterodimer.

Authors:  M C Hall; H Wang; D A Erie; T A Kunkel
Journal:  J Mol Biol       Date:  2001-09-28       Impact factor: 5.469

5.  Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.

Authors:  R Scott Williams; Gerald E Dodson; Oliver Limbo; Yoshiki Yamada; Jessica S Williams; Grant Guenther; Scott Classen; J N Mark Glover; Hiroshi Iwasaki; Paul Russell; John A Tainer
Journal:  Cell       Date:  2009-10-02       Impact factor: 41.582

6.  CtIP Mutations Cause Seckel and Jawad Syndromes.

Authors:  Per Qvist; Pablo Huertas; Sonia Jimeno; Mette Nyegaard; Muhammad J Hassan; Stephen P Jackson; Anders D Børglum
Journal:  PLoS Genet       Date:  2011-10-06       Impact factor: 5.917

7.  CtIP tetramer assembly is required for DNA-end resection and repair.

Authors:  Owen R Davies; Josep V Forment; Meidai Sun; Rimma Belotserkovskaya; Julia Coates; Yaron Galanty; Mukerrem Demir; Christopher R Morton; Neil J Rzechorzek; Stephen P Jackson; Luca Pellegrini
Journal:  Nat Struct Mol Biol       Date:  2015-01-05       Impact factor: 15.369

8.  Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.

Authors:  Sara N Andres; C Denise Appel; James W Westmoreland; Jessica S Williams; Yvonne Nguyen; Patrick D Robertson; Michael A Resnick; R Scott Williams
Journal:  Nat Struct Mol Biol       Date:  2015-01-12       Impact factor: 15.369

9.  Regulatory control of DNA end resection by Sae2 phosphorylation.

Authors:  Elda Cannavo; Dominic Johnson; Sara N Andres; Vera M Kissling; Julia K Reinert; Valerie Garcia; Dorothy A Erie; Daniel Hess; Nicolas H Thomä; Radoslav I Enchev; Matthias Peter; R Scott Williams; Matt J Neale; Petr Cejka
Journal:  Nat Commun       Date:  2018-10-01       Impact factor: 14.919

Review 10.  Role of the Mre11 Complex in Preserving Genome Integrity.

Authors:  Julyun Oh; Lorraine S Symington
Journal:  Genes (Basel)       Date:  2018-11-29       Impact factor: 4.096
  10 in total

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