Literature DB >> 3082324

The stimulation of tricarboxylic acid-cycle flux by alpha-adrenergic agonists in perfused rat liver.

W M Taylor, E van de Pol, F L Bygrave.   

Abstract

Output of 14CO2 from 1-14C-labelled glutamate, 2-oxoglutarate or octanoate and from 4-methyl-2-oxo[2-14C]pentanoate was increased by more than 100% after infusion of phenylephrine into perfused livers of fed rats. Infusion of ethanol or sorbitol raised 3-hydroxybutyrate/acetoacetate ratios and decreased the output of 14CO2. Increases in 14CO2 output induced by phenylephrine were observed in the presence or absence of ethanol or sorbitol and were accompanied by elevated 3-hydroxybutyrate/acetoacetate ratios under all conditions examined. Phenylephrine had no effect on total tissue ATP/ADP ratios in livers from fed or starved rats. The data suggest that phenylephrine-induced increases in tricarboxylic acid-cycle flux do not arise from lowered matrix NADH/NAD+ or ATP/ADP ratios.

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Year:  1986        PMID： 3082324      PMCID： PMC1153030          DOI： 10.1042/bj2330321

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  20 in total

1.  Comparative studies on the influence of hormones on metabolite compartmentation in isolated liver cells during gluconeogenesis from lactate.

Authors:  E A Siess; D G Brocks; O H Wieland
Journal:  Biochem Soc Trans       Date:  1978       Impact factor: 5.407

2.  The stimulation of the mitochondrial uncoupler-dependent ATPase in isolated hepatocytes by catecholamines and glucagon and its relationship to gluconeogenesis.

Authors:  M A Titheradge; J L Stringer; R C Haynes
Journal:  Eur J Biochem       Date:  1979-12

3.  The calorigenic nature of hepatic ketogenesis: an explanation for the stimulation of respiration induced by fatty acid substrates.

Authors:  M N Berry; D G Clark; A R Grivell; P G Wallace
Journal:  Eur J Biochem       Date:  1983-03-01

4.  The hormonal stimulation of ureogenesis in isolated hepatocytes through increases in mitochondrial ATP production.

Authors:  M A Titheradge; R C Haynes
Journal:  Arch Biochem Biophys       Date:  1980-04-15       Impact factor: 4.013

5.  Functional compartmentation of acetaldehyde oxidation in rat liver.

Authors:  R Parrilla; K Okawa; K O Lindros; U J Zimmerman; K Kobayashi; J R Williamson
Journal:  J Biol Chem       Date:  1974-08-10       Impact factor: 5.157

6.  Role of calcium ions in the regulation of intramitochondrial metabolism. Effects of Na+, Mg2+ and ruthenium red on the Ca2+-stimulated oxidation of oxoglutarate and on pyruvate dehydrogenase activity in intact rat heart mitochondria.

Authors:  R M Denton; J G McCormack; N J Edgell
Journal:  Biochem J       Date:  1980-07-15       Impact factor: 3.857

7.  Studies on alpha-adrenergic-induced respiration and glycogenolysis in perfused rat liver.

Authors:  P H Reinhart; W M Taylor; F L Bygrave
Journal:  J Biol Chem       Date:  1982-02-25       Impact factor: 5.157

8.  Stimulation of [1-14C]oleate oxidation to 14CO2 in isolated rat hepatocytes by the catecholamines, vasopressin and angiotensin. A possible mechanism of action.

Authors:  M C Sugden; D I Watts
Journal:  Biochem J       Date:  1983-04-15       Impact factor: 3.857

9.  Assessment of the flux of mitochondrial acetyl-CoA in liver and kidney by using the differential production of 14CO2 from tracers of (1-14C)- and (2-14C)-labelled 4-methyl-2-oxovalerate.

Authors:  J F Tomera; R R Kopito; H Brunengraber
Journal:  Biochem J       Date:  1983-01-15       Impact factor: 3.857

10.  Changes in the subcellular distribution of metabolites due to ethanol oxidation in the perfused rat liver.

Authors:  S Soboll; H W Heldt; R Scholz
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1981-03
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  2 in total

Review 1.  Dehydrogenase activation by Ca2+ in cells and tissues.

Authors:  R G Hansford
Journal:  J Bioenerg Biomembr       Date:  1991-12       Impact factor: 2.945

2.  Intramitochondrial regulation of fatty acid beta-oxidation occurs between flavoprotein and ubiquinone. A role for changes in the matrix volume.

Authors:  A P Halestrap; J L Dunlop
Journal:  Biochem J       Date:  1986-11-01       Impact factor: 3.857
  2 in total

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