Literature DB >> 30819554

The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome.

Nirupama Ramkumar1, Donald E Kohan2.   

Abstract

The (pro)renin receptor (PRR) is a multifunctional protein that is expressed in multiple organs. Binding of prorenin/renin to the PRR activates angiotensin II-dependent and angiotensin II-independent pathways. The PRR is also involved in autophagy and Wnt/ß catenin signaling, functions that are not contingent on prorenin binding. Emerging evidence suggests that the PRR plays an important role in blood pressure regulation and glucose and lipid metabolism. Herein, we review PRR function in health and disease, with particular emphasis on hypertension and the metabolic syndrome.
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  (pro)renin receptor; hypertension; insulin resistance; obesity

Mesh：

Substances：

Year:  2019        PMID： 30819554      PMCID： PMC6478511          DOI： 10.1016/j.kint.2018.10.042

Source DB:  PubMed          Journal:  Kidney Int        ISSN： 0085-2538            Impact factor:   10.612


  107 in total

1.  Prorenin and its ancient receptor.

Authors:  Céline Burcklé; Michael Bader
Journal:  Hypertension       Date:  2006-08-28       Impact factor: 10.190

2.  Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men.

Authors:  Christian Ott; Markus P Schneider; Christian Delles; Markus P Schlaich; Karl F Hilgers; Roland E Schmieder
Journal:  Pharmacogenet Genomics       Date:  2011-06       Impact factor: 2.089

3.  Intracerebroventricular infusion of the (Pro)renin receptor antagonist PRO20 attenuates deoxycorticosterone acetate-salt-induced hypertension.

Authors:  Wencheng Li; Michelle N Sullivan; Sheng Zhang; Caleb J Worker; Zhenggang Xiong; Robert C Speth; Yumei Feng
Journal:  Hypertension       Date:  2014-11-24       Impact factor: 10.190

4.  The Effect of Combined Treatment with the (Pro)Renin Receptor Blocker HRP and Quinapril in Type 1 Diabetic Rats.

Authors:  Gábor Kökény; Lilla Fang; Csaba Révész; Miklós M Mózes; Péter Vörös; Gábor Szénási; László Rosivall
Journal:  Kidney Blood Press Res       Date:  2017-04-03       Impact factor: 2.687

5.  Targeted deletion of murine CEACAM 1 activates PI3K-Akt signaling and contributes to the expression of (Pro)renin receptor via CREB family and NF-κB transcription factors.

Authors:  Jiqian Huang; Kelly J Ledford; William B Pitkin; Lucia Russo; Sonia M Najjar; Helmy M Siragy
Journal:  Hypertension       Date:  2013-06-03       Impact factor: 10.190

6.  Neuron-specific (pro)renin receptor knockout prevents the development of salt-sensitive hypertension.

Authors:  Wencheng Li; Hua Peng; Eamonn P Mehaffey; Christie D Kimball; Justin L Grobe; Jeanette M G van Gool; Michelle N Sullivan; Scott Earley; A H Jan Danser; Atsuhiro Ichihara; Yumei Feng
Journal:  Hypertension       Date:  2013-11-18       Impact factor: 10.190

7.  Serum soluble (pro)renin receptor levels in patients with essential hypertension.

Authors:  Satoshi Morimoto; Takashi Ando; Michita Niiyama; Yasufumi Seki; Naohiro Yoshida; Daisuke Watanabe; Fumiko Kawakami-Mori; Hiroyuki Kobori; Akira Nishiyama; Atsuhiro Ichihara
Journal:  Hypertens Res       Date:  2014-03-20       Impact factor: 3.872

8.  Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp.

Authors:  Yasufumi Seki; Atsuhiro Ichihara; Yuki Mizuguchi; Mariyo Sakoda; Asako Kurauchi-Mito; Tatsuya Narita; Kenichiro Kinouchi; Kanako Bokuda; Hiroshi Itoh
Journal:  Front Biosci (Elite Ed)       Date:  2010-06-01

9.  Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects.

Authors:  Maria A Rujano; Magda Cannata Serio; Ganna Panasyuk; Romain Péanne; Janine Reunert; Daisy Rymen; Virginie Hauser; Julien H Park; Peter Freisinger; Erika Souche; Maria Clara Guida; Esther M Maier; Yoshinao Wada; Stefanie Jäger; Nevan J Krogan; Oliver Kretz; Susana Nobre; Paula Garcia; Dulce Quelhas; Thomas D Bird; Wendy H Raskind; Michael Schwake; Sandrine Duvet; Francois Foulquier; Gert Matthijs; Thorsten Marquardt; Matias Simons
Journal:  J Exp Med       Date:  2017-11-10       Impact factor: 14.307

10.  Conditional ablation of the prorenin receptor in nephron progenitor cells results in developmental programming of hypertension.

Authors:  Renfang Song; Laura Kidd; Adam Janssen; Ihor V Yosypiv
Journal:  Physiol Rep       Date:  2018-04
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  9 in total

1.  Soluble (pro)renin receptor regulation of ENaC involved in aldosterone signaling in cultured collecting duct cells.

Authors:  Fei Wang; Renfei Luo; Kexin Peng; Xiyang Liu; Chuanming Xu; Xiaohan Lu; Sunhapas Soodvilai; Tianxin Yang
Journal:  Am J Physiol Renal Physiol       Date:  2019-12-16

2.  COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats.

Authors:  Fei Wang; Ying Sun; Renfei Luo; Xiaohan Lu; Baoxue Yang; Tianxin Yang
Journal:  Am J Physiol Renal Physiol       Date:  2020-08-17

3.  Longitudinal Changes in Prorenin and Renin in the Chronic Renal Insufficiency Cohort.

Authors:  Monique E Cho; Carol Sweeney; Nora Fino; Tom Greene; Nirupama Ramkumar; Yufeng Huang; Ana C Ricardo; Tariq Shafi; Rajat Deo; Amanda Anderson; Katherine T Mills; Alfred K Cheung
Journal:  Am J Nephrol       Date:  2021-03-18       Impact factor: 3.754

4.  Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury.

Authors:  Nirupama Ramkumar; Deborah Stuart; Caitlin S Peterson; Chunyan Hu; William Wheatley; Jae Min Cho; J David Symons; Donald E Kohan
Journal:  Circ Res       Date:  2021-04-23       Impact factor: 23.213

5.  Comparative Proteome Analysis Indicates The Divergence between The Head and Tail Regeneration in Planarian.

Authors:  Xiaoguang Chen; Yumei Liu; Xuemin Zhu; Qiongxia Lv
Journal:  Cell J       Date:  2021-11-23       Impact factor: 2.479

6.  Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling.

Authors:  Kai Xue; Yurong Wang; Yan Wang; Hui Fang
Journal:  Oxid Med Cell Longev       Date:  2021-11-26       Impact factor: 6.543

Review 7.  Insulin Resistance Is Cheerfully Hitched with Hypertension.

Authors:  Susmita Sinha; Mainul Haque
Journal:  Life (Basel)       Date:  2022-04-10

Review 8.  The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease.

Authors:  Amity F Eaton; Maria Merkulova; Dennis Brown
Journal:  Am J Physiol Cell Physiol       Date:  2020-12-16       Impact factor: 4.249

Review 9.  The renin-angiotensin system in COVID-19: Why ACE2 targeting by coronaviruses produces higher mortality in elderly hypertensive patients?

Authors:  Sven Kurbel
Journal:  Bioessays       Date:  2020-12-18       Impact factor: 4.653
  9 in total

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