Literature DB >> 20515768

Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp.

Yasufumi Seki1, Atsuhiro Ichihara, Yuki Mizuguchi, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh.   

Abstract

To examine the involvement of (pro)renin receptor in the accelerated organ damage in streptozotocin-induced diabetic male SHRsp, the rats fed a high-salt diet were divided into 5 groups: a group treated with the vehicle, a group treated with 15 mg/kg/day of imidapril (ACEi), a group treated with 60 mg/kg/day of imidapril (High ACEi), a group treated with handle region peptide (HRP), and a group treated with both ACEi and HRP (ACEi+HRP). After 8 weeks, the arterial pressure was similar in the vehicle and HRP groups and decreased in the ACEi-treated groups. The renal angiotensin II content decreased similarly in the groups treated with ACEi and/or HRP. Urinary protein excretion also decreased in the ACEi, High ACEi, and HRP groups and significantly further decreased in the ACEi+HRP group. The heart weight of the ACEi+HRP group was significantly lower than that of any other groups, although the cardiac angiotensin II levels decreased similarly in the groups treated with ACEi and/or HRP. Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp.

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Year:  2010        PMID: 20515768     DOI: 10.2741/e156

Source DB:  PubMed          Journal:  Front Biosci (Elite Ed)        ISSN: 1945-0494


  7 in total

1.  Role of (pro)renin receptor in albumin overload-induced nephropathy in rats.

Authors:  Hui Fang; Mokan Deng; Linlin Zhang; Aihua Lu; Jiahui Su; Chuanming Xu; Li Zhou; Lei Wang; Jing-Song Ou; Weidong Wang; Tianxin Yang
Journal:  Am J Physiol Renal Physiol       Date:  2018-05-30

Review 2.  The (pro)renin receptor: an emerging player in hypertension and metabolic syndrome.

Authors:  Nirupama Ramkumar; Donald E Kohan
Journal:  Kidney Int       Date:  2019-02-26       Impact factor: 10.612

3.  Increased (pro)renin receptor expression in the subfornical organ of hypertensive humans.

Authors:  Silvana G Cooper; Darshan P Trivedi; Rieko Yamamoto; Caleb J Worker; Cheng-Yuan Feng; Jacob T Sorensen; Wei Yang; Zhenggang Xiong; Yumei Feng
Journal:  Am J Physiol Heart Circ Physiol       Date:  2017-12-22       Impact factor: 4.733

4.  (Pro)renin receptor antagonist PRO20 attenuates nephrectomy-induced nephropathy in rats via inhibition of intrarenal RAS and Wnt/β-catenin signaling.

Authors:  Yan Wang; Yurong Wang; Kai Xue; Huaijie Wang; Jingjing Zhou; Feng Gao; Chengde Li; Tianxin Yang; Hui Fang
Journal:  Physiol Rep       Date:  2021-06

Review 5.  The (pro)renin receptor. A decade of research: what have we learned?

Authors:  Manne Krop; Xifeng Lu; A H Jan Danser; Marcel E Meima
Journal:  Pflugers Arch       Date:  2012-04-28       Impact factor: 3.657

Review 6.  Therapeutic perspectives in hypertension: novel means for renin-angiotensin-aldosterone system modulation and emerging device-based approaches.

Authors:  Thomas Unger; Ludovit Paulis; Domenic A Sica
Journal:  Eur Heart J       Date:  2011-09-27       Impact factor: 29.983

7.  Elevated (Pro)renin Receptor Expression Contributes to Maintaining Aerobic Metabolism in Growth Hormone Deficiency.

Authors:  Yasufumi Seki; Midori Yatabe; Chikahito Suda; Satoshi Morimoto; Atsuhiro Ichihara
Journal:  J Endocr Soc       Date:  2018-02-09
  7 in total

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