| Literature DB >> 30818054 |
Pedro Rojas-Morales1, Juan Carlos León-Contreras2, Omar Emiliano Aparicio-Trejo1, Jazmin Gabriela Reyes-Ocampo1, Omar Noel Medina-Campos1, Angélica Saraí Jiménez-Osorio1, Susana González-Reyes1, Brenda Marquina-Castillo2, Rogelio Hernández-Pando2, Diana Barrera-Oviedo3, Laura Gabriela Sánchez-Lozada4, José Pedraza-Chaverri1, Edilia Tapia5.
Abstract
Food deprivation protects against ischemia-reperfusion (IR) injury through unknown mechanisms. In an experimental rat model of acute IR injury, we found that preoperative fasting for 3 days protects rats from tubular damage and renal functional decline by increasing antioxidant protection independently of the NF-E2-related factor 2 (Nrf2), and by maintaining mitochondrial morphology and function. In addition, further analysis revealed that fasting protects against tubulointerstitial fibrosis. In summary, our results point out to fasting as a robust nutritional intervention to limit oxidative stress and mitochondrial dysfunction in early acute kidney injury and also to promote long-term protection against fibrosis.Entities:
Keywords: Acute kidney injury; Chronic kidney disease; Fasting; Fibrosis; Ischemia-reperfusion injury; Mitochondrial dysfunction; Oxidative stress
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Year: 2019 PMID： 30818054 DOI： 10.1016/j.freeradbiomed.2019.02.018
Source DB: PubMed Journal: Free Radic Biol Med ISSN： 0891-5849 Impact factor: 7.376