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Literature DB >> 30814110

EPB41L5 Mediates TGFβ-Induced Metastasis of Gastric Cancer.

Mi-Hyeon Jeong¹, Soo-Yeon Park¹, Seung-Hyun Lee¹, JaeSung Seo¹, Jung-Yoon Yoo¹, Seung-Ho Park², Mi Jeong Kim¹, SooYeon Lee¹, Subhin Jang¹, Hyo-Kyoung Choi³, Jae Eun Lee⁴, Su-Jin Shin⁵, Kyung-Chul Choi⁶, Jae-Ho Cheong^7,4, Ho-Geun Yoon⁷.

Abstract

PURPOSE: Because of disease heterogeneity, limited studies on effective chemotherapies and therapeutic agents for advanced gastric cancer are available. Erythrocyte membrane protein band 4.1-like 5 (EPB41L5) has critical roles in renal and breast cancer metastasis. However, its role in metastatic gastric cancer remains unknown. EXPERIMENTAL
DESIGN: The specimens of 78 gastric cancer patients were analyzed by oligonucleotide microarray and survival analysis. In vitro experiments and metastatic mice models were used to assess the effects of EPB41L5 on gastric cancer metastasis.
RESULTS: Gastric cancer patients with high EPB41L5 levels had poor prognosis and low survival rate. Further, TGFβ1-induced EPB41L5 expression promoted gastric cancer cell migration and invasion by Smad-dependent TGFβ signaling. Phospho-Smad3 recruitment to the EPB41L5 promoter was significantly inhibited by a TGFβ inhibitor. EPB41L5 overexpression increased lung metastasis of gastric cancer cells in nude mice, which was completely reversed by anti-EPB41L5 monoclonal antibody treatment. Importantly, p120-catenin knockdown abolished EPB41L5-enhanced gastric cancer cell metastasis. Anti-EPB41L5 monoclonal antibody treatment blocked the association of EPB41L5 with p120-catenin.
CONCLUSIONS: TGFβ/EPB41L5/p120-catenin axis regulates gastric cancer cell metastasis, and EPB41L5 is a promising therapeutic target for advanced gastric cancer. ©2019 American Association for Cancer Research.

Entities: Chemical Disease Gene Species

Year: 2019 PMID： 30814110 DOI： 10.1158/1078-0432.CCR-18-2959

Source DB: PubMed Journal: Clin Cancer Res ISSN： 1078-0432 Impact factor: 12.531

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10 in total

EPB41L5 Mediates TGFβ-Induced Metastasis of Gastric Cancer.

Review 1. T Cell Cytokines Impact Epithelial Cell Responses during Helicobacter pylori Infection.

2. CD2AP inhibits metastasis in gastric cancer by promoting cellular adhesion and cytoskeleton assembly.

3. LncRNA FEZF1-AS1 Modulates Cancer Stem Cell Properties of Human Gastric Cancer Through miR-363-3p/HMGA2.

4. Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications.

5. Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis.

6. Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression.

7. Bioinformatics analysis of the circRNA-miRNA-mRNA network for atrial fibrillation.

Review 8. Brain Vascular Microenvironments in Cancer Metastasis.

9. PTBP3 mediates TGF-β-induced EMT and metastasis of lung adenocarcinoma.

10. TGF-β1-mediated exosomal lnc-MMP2-2 increases blood-brain barrier permeability via the miRNA-1207-5p/EPB41L5 axis to promote non-small cell lung cancer brain metastasis.