Mathilde Lambert1, Florence Gressier2. 1. 1 Interne DES psychiatrie Ile de France, Service de Psychiatrie, Hôpital de Bicêtre, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France. 2. 2 Responsable de l'Unité de Psychiatrie Périnatale du CHU de Bicêtre, CESP, Inserm UMR1178, Univ Paris Sud, Service de Psychiatrie, Hôpital de Bicêtre, Assistance Publique Hôpitaux de Paris, Le Kremlin Bicêtre, France.
Abstract
OBJECTIVE: Postpartum Depression (PPD) affects over 15% new mothers. Its etiology is multifactorial and still partly unknown. Some hypotheses suggest a link with inflammation. This review aims to explore the existence of inflammatory biomarkers associated with PPD. The possibility of potential adjunct treatments, linked with these biomarkers, will be discussed. METHOD: The systematic review of literature was performed using in PubMed, PsycInfo and Embase, and 25 articles were included. Various biomarkers were identified. The most often studied are C-reactive protein (CRP), interleukins 6 and 10, tumor necrosis factor-alpha and interferon-gamma. RESULTS: Although few results appear as significant during the various testing times, the dosage of some inflammation biomarkers, including CRP, at the very end of pregnancy or immediately after delivery could predict PPD. Interactions between inflammation and the corticotropic axis could explain PPD onset. Epigenetic mechanisms could lead to pro-inflammatory state. Several therapeutics provide interest due to their anti-inflammatory property. CONCLUSIONS: Further studies are needed to assess these biomarkers value as predictive factors of PPD and to consider adjunct treatments to antidepressants. If this value is confirmed, the inflammatory marker dosage, in particular CRP, could help to provide early screening of women at risk of PPD, parallel of the clinical evaluation. A zinc supplementation could then be offered.
OBJECTIVE:Postpartum Depression (PPD) affects over 15% new mothers. Its etiology is multifactorial and still partly unknown. Some hypotheses suggest a link with inflammation. This review aims to explore the existence of inflammatory biomarkers associated with PPD. The possibility of potential adjunct treatments, linked with these biomarkers, will be discussed. METHOD: The systematic review of literature was performed using in PubMed, PsycInfo and Embase, and 25 articles were included. Various biomarkers were identified. The most often studied are C-reactive protein (CRP), interleukins 6 and 10, tumor necrosis factor-alpha and interferon-gamma. RESULTS: Although few results appear as significant during the various testing times, the dosage of some inflammation biomarkers, including CRP, at the very end of pregnancy or immediately after delivery could predict PPD. Interactions between inflammation and the corticotropic axis could explain PPD onset. Epigenetic mechanisms could lead to pro-inflammatory state. Several therapeutics provide interest due to their anti-inflammatory property. CONCLUSIONS: Further studies are needed to assess these biomarkers value as predictive factors of PPD and to consider adjunct treatments to antidepressants. If this value is confirmed, the inflammatory marker dosage, in particular CRP, could help to provide early screening of women at risk of PPD, parallel of the clinical evaluation. A zinc supplementation could then be offered.
Entities:
Keywords:
C-réactive protéine; biomarqueurs; cytokines; dépression du post-partum; inflammation
Authors: Thaddeus W W Pace; Tanja C Mletzko; Oyetunde Alagbe; Dominique L Musselman; Charles B Nemeroff; Andrew H Miller; Christine M Heim Journal: Am J Psychiatry Date: 2006-09 Impact factor: 18.112
Authors: M Maes; A H Lin; W Ombelet; K Stevens; G Kenis; R De Jongh; J Cox; E Bosmans Journal: Psychoneuroendocrinology Date: 2000-02 Impact factor: 4.905
Authors: Claudia Holzman; Janet Eyster; Linda Beth Tiedje; Lee Anne Roman; Elizabeth Seagull; Mohammad Hossein Rahbar Journal: Matern Child Health J Date: 2006-01-07
Authors: Andrea Danese; Carmine M Pariante; Avshalom Caspi; Alan Taylor; Richie Poulton Journal: Proc Natl Acad Sci U S A Date: 2007-01-17 Impact factor: 11.205