Maureen W Groer1, Mitzi W Davis. 1. University of South Florida College of Nursing, Tampa, USA. groer@hsc.usf.edu
Abstract
OBJECTIVE: To analyze relationships between stress, moods, and immunity in breastfeeding compared to formula-feeding mothers. DESIGN: A cross-sectional study of 181 healthy mothers, exclusively breastfeeding or formula feeding, studied at 4 to 6 weeks after childbirth. SETTING: Mothers were recruited in the postpartum unit of the hospital and then visited in their homes once at 4 to 6 weeks after childbirth for data collection. MAIN OUTCOME MEASURES: Stress, mood, infection symptoms, and serum levels of interferon-gamma and interleukin-10 were measured. RESULTS: Formula-feeding mothers had evidence of decreased interferon-gamma and a decreased serum Th1/Th2 ratio (interferon-gamma/interleukin-10) when perceived stress, dysphoric moods, and negative life events were high, an effect consistent with depression of cellular immunity. However, women who were breastfeeding did not show these relationships. CONCLUSIONS: The data suggest that breastfeeding confers some psychoneuroimmunological benefit to mothers, perhaps through prolactin or hypothalamic-hypophyseal-adrenocortical axis stress refractoriness. (c) 2006, AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses
OBJECTIVE: To analyze relationships between stress, moods, and immunity in breastfeeding compared to formula-feeding mothers. DESIGN: A cross-sectional study of 181 healthy mothers, exclusively breastfeeding or formula feeding, studied at 4 to 6 weeks after childbirth. SETTING: Mothers were recruited in the postpartum unit of the hospital and then visited in their homes once at 4 to 6 weeks after childbirth for data collection. MAIN OUTCOME MEASURES: Stress, mood, infection symptoms, and serum levels of interferon-gamma and interleukin-10 were measured. RESULTS: Formula-feeding mothers had evidence of decreased interferon-gamma and a decreased serum Th1/Th2 ratio (interferon-gamma/interleukin-10) when perceived stress, dysphoric moods, and negative life events were high, an effect consistent with depression of cellular immunity. However, women who were breastfeeding did not show these relationships. CONCLUSIONS: The data suggest that breastfeeding confers some psychoneuroimmunological benefit to mothers, perhaps through prolactin or hypothalamic-hypophyseal-adrenocortical axis stress refractoriness. (c) 2006, AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses
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