Literature DB >> 30805894

Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population.

AsmaGul Naz1, Muhammad Assad Aslam1, Abrar Ul Haq Khan2, Sumaira Rasul1, Hamid Manzoor1, Rehana Iqbal3, Ahmed Shehzad4, Muhammad Ali5.   

Abstract

Tuberculosis is becoming a global issue with raising occurrences; particularly in developing countries, the situation is alarming. Besides environmental factors, host genetic factors are vital in disease development. A demographical and genotypic analysis in relation to tuberculosis commencement is conducted in a Pakistani population, and genotypic frequency of EBI3 (rs4740) was analyzed. Allelic frequencies of EBI3 (rs4740) were significantly associated with disease susceptibility in the reviewed population. Analysis for EBI3 (rs4740) genotyping showed a significant association of "GG" with reduced risk for disease. Moreover, females and older age found to be more perilous to develop TB while smoking and a family history of TB are additional risk factors for disease development. Further work with a larger population is necessary to identify the true causative variants of tuberculosis.

Entities:  

Keywords:  EBI3 (rs4740); Polymorphism; Smoking; Tuberculosis

Mesh：

Substances：

Year:  2019        PMID： 30805894      PMCID： PMC6863315          DOI： 10.1007/s42770-019-00048-8

Source DB:  PubMed          Journal:  Braz J Microbiol        ISSN： 1517-8382            Impact factor:   2.476


  35 in total

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Journal:  Tuberculosis (Edinb)       Date:  2015-04-17       Impact factor: 3.131

2.  Lack of association between polymorphisms from genome-wide association studies and tuberculosis in the Chinese population.

Authors:  Lin-Dan Ji; Peng-Fei Chai; Bi-Bo Zhou; Nelson L S Tang; Wen-Hua Xing; Fang Yuan; Li-Juan Fei; Li-Na Zhang; Jin Xu
Journal:  Scand J Infect Dis       Date:  2012-10-31

3.  Association between interleukin-35 polymorphisms and coronary heart disease in the Chinese Zhuang population: a case-control study.

Authors:  Yingzhong Lin; Yan Xue; Xinshun Huang; Jianyong Lu; Zicong Yang; Jing Ye; Shu Zhang; Ling Liu; Yu Liu; Ying Shi
Journal:  Coron Artery Dis       Date:  2018-08       Impact factor: 1.439

4.  Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis.

Authors:  J Keane; M K Balcewicz-Sablinska; H G Remold; G L Chupp; B B Meek; M J Fenton; H Kornfeld
Journal:  Infect Immun       Date:  1997-01       Impact factor: 3.441

5.  Acute cigarette smoke exposure induces apoptosis of alveolar macrophages.

Authors:  K Aoshiba; J Tamaoki; A Nagai
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2001-12       Impact factor: 5.464

Review 6.  The resumption of consumption -- a review on tuberculosis.

Authors:  Rodrigo Gay Ducati; Antonio Ruffino-Netto; Luiz Augusto Basso; Diógenes Santiago Santos
Journal:  Mem Inst Oswaldo Cruz       Date:  2006-11       Impact factor: 2.743

7.  IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells.

Authors:  Stefan Pflanz; Jackie C Timans; Jeanne Cheung; Rency Rosales; Holger Kanzler; Jonathan Gilbert; Linda Hibbert; Tatyana Churakova; Marilyn Travis; Elena Vaisberg; Wendy M Blumenschein; Jeanine D Mattson; Janet L Wagner; Wayne To; Sandra Zurawski; Terrill K McClanahan; Daniel M Gorman; J Fernando Bazan; Rene de Waal Malefyt; Donna Rennick; Robert A Kastelein
Journal:  Immunity       Date:  2002-06       Impact factor: 31.745

8.  Association between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects.

Authors:  Yuan Zhang; Su Duan; Xin Wei; Yanming Zhao; Liping Zhao; Luo Zhang
Journal:  Hum Immunol       Date:  2012-07-23       Impact factor: 2.850

9.  Increased P-35, EBI3 Transcripts and Other Treg Markers in Peripheral Blood Mononuclear Cells of Breast Cancer Patients with Different clinical Stages.

Authors:  Maryam Hamidinia; Mehri Ghafourian Boroujerdnia; Abdolhassan Talaiezadeh; Ghasem Solgi; Reyhaneh Roshani; Sara Iranprast; Ali Khodadadi
Journal:  Adv Pharm Bull       Date:  2015-06-01

10.  Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.

Authors:  Thorsten Thye; Fredrik O Vannberg; Rolf D Horstmann; Adrian V S Hill; Sunny H Wong; Ellis Owusu-Dabo; Ivy Osei; John Gyapong; Giorgio Sirugo; Fatou Sisay-Joof; Anthony Enimil; Margaret A Chinbuah; Sian Floyd; David K Warndorff; Lifted Sichali; Simon Malema; Amelia C Crampin; Bagrey Ngwira; Yik Y Teo; Kerrin Small; Kirk Rockett; Dominic Kwiatkowski; Paul E Fine; Philip C Hill; Melanie Newport; Christian Lienhardt; Richard A Adegbola; Tumani Corrah; Andreas Ziegler; Andrew P Morris; Christian G Meyer
Journal:  Nat Genet       Date:  2010-08-08       Impact factor: 38.330
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  1 in total

1.  Multidrug-resistant strains of Mycobacterium complex species in Egyptian farm animals, veterinarians, and farm and abattoir workers.

Authors:  Hossam A Abdelsadek; Hassan M Sobhy; Kh F Mohamed; Sahar H A Hekal; Amany N Dapgh; Ashraf S Hakim
Journal:  Vet World       Date:  2020-10-14
  1 in total

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