| Literature DB >> 12121660 |
Stefan Pflanz1, Jackie C Timans, Jeanne Cheung, Rency Rosales, Holger Kanzler, Jonathan Gilbert, Linda Hibbert, Tatyana Churakova, Marilyn Travis, Elena Vaisberg, Wendy M Blumenschein, Jeanine D Mattson, Janet L Wagner, Wayne To, Sandra Zurawski, Terrill K McClanahan, Daniel M Gorman, J Fernando Bazan, Rene de Waal Malefyt, Donna Rennick, Robert A Kastelein.
Abstract
An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.Entities:
Mesh：
Substances：
Year: 2002 PMID： 12121660 DOI： 10.1016/s1074-7613(02)00324-2
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745