Igor Figueiredo Pereira1, Ramon Targino Firmino2, Henrique Cortes Meira3, Belmiro Cavalcanti DO Egito Vasconcelos4, Vladimir Reimar Augusto DE Souza Noronha5, Vagner Rodrigues Santos3. 1. Department of Prosthodontics and Bucco-Facial Surgery, School of Dentistry, University of Pernambuco, Camaragibe, Brazil figueiredo.ctbmf@gmail.com. 2. Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Minas Gerais, Pampulha Belo Horizonte, Brazil. 3. Department of Clinical, Pathology and Surgery, School of Dentistry, Federal University of Minas Gerais, Pampulha Belo Horizonte, Brazil. 4. Department of Prosthodontics and Bucco-Facial Surgery, School of Dentistry, University of Pernambuco, Camaragibe, Brazil. 5. Department of Surgery, University Center of Newton Paiva, Belo Horizonte, Brazil.
Abstract
Aim: To determine the prevalence of radiation-induced oral mucositis (OM) and associated factors. PATIENTS AND METHODS: A cross-sectional retrospective study was performed at a reference dental care center. The medical records of patients submitted to radiotherapy for the treatment of head and neck cancer were used to collect clinical and demographic variables. The data were submitted to descriptive analysis and multivariate Poisson regression with robust variance [p<0.05; 95% confidence intervaI (CI)]. RESULTS: Four hundred and thirteen patients were analyzed. The mean age was 55±14 years. The prevalence of OM in the overall sample was 41.9% and was higher among males (78.2%). The following variables were significantly associated with the outcome: radiation dose [prevalence ratio (PR)= 1.04; 95% CI=1.02-1.06]; concomitant chemotherapy (PR=1.48, 95% CI=1.05-2.08); oral candidiasis (PR=1.97, 95% CI=1.44-2.68); and osteoradionecrosis (PR=1.51, 95% CI=1.10-2.06). CONCLUSION: Radiation-induced OM was associated with radiation dose, concomitant chemotherapy, oral candidiasis and osteoradionecrosis. The rate of OM underscores the importance of adequate oral care prior to treatment for head and neck cancer. Copyright
Aim: To determine the prevalence of radiation-induced oral mucositis (OM) and associated factors. PATIENTS AND METHODS: A cross-sectional retrospective study was performed at a reference dental care center. The medical records of patients submitted to radiotherapy for the treatment of head and neck cancer were used to collect clinical and demographic variables. The data were submitted to descriptive analysis and multivariate Poisson regression with robust variance [p<0.05; 95% confidence intervaI (CI)]. RESULTS: Four hundred and thirteen patients were analyzed. The mean age was 55±14 years. The prevalence of OM in the overall sample was 41.9% and was higher among males (78.2%). The following variables were significantly associated with the outcome: radiation dose [prevalence ratio (PR)= 1.04; 95% CI=1.02-1.06]; concomitant chemotherapy (PR=1.48, 95% CI=1.05-2.08); oral candidiasis (PR=1.97, 95% CI=1.44-2.68); and osteoradionecrosis (PR=1.51, 95% CI=1.10-2.06). CONCLUSION: Radiation-induced OM was associated with radiation dose, concomitant chemotherapy, oral candidiasis and osteoradionecrosis. The rate of OM underscores the importance of adequate oral care prior to treatment for head and neck cancer. Copyright