Yoonyoung Chung1, Hanbit Cho2, Gyeong Hyeon Jo2, Yonghyun Jun3. 1. Department of Anatomy, School of Medicine, Chosun University, Gwang-ju, Republic of Korea. 2. School of Medicine, Chosun University, Gwang-ju, Republic of Korea. 3. Department of Anatomy, School of Medicine, Chosun University, Gwang-ju, Republic of Korea jyh1483@chosun.ac.kr.
Abstract
BACKGROUND/AIM: Cerebral ischemia is a major cause of abnormal brain development. In a cerebral ischemia model, periventricular leukomalacia (PVL), white matter lesion and a decrease in the number of subcortical neurons were observed. The aim of this study was to investigate the effect of hypoxia on neurogenesis and cell survival. MATERIALS AND METHODS: In seven-day postnatal rats, the right carotid artery was ligated. The rats were incubated either in a regular normoxic chamber (control group) or in a hypoxic chamber (PVL group, 8% 02 and 92% N2 at 37°C) for 2 h. Nestin- and NeuN-positive neurons were detected by immunohistochemistry. RESULTS: The densities of nestin-immunoreactivity (IR) cells in the cerebral parietal cortex and subventricular zone were increased with hypoxia. NeuN-IR cells in the cerebral cortex were significantly decreased in the PVL group. CONCLUSION: Perinatal white matter injury induced neurogenesis, while the survival of neurons was decreased in the cerebral cortex. Copyright
BACKGROUND/AIM: Cerebral ischemia is a major cause of abnormal brain development. In a cerebral ischemia model, periventricular leukomalacia (PVL), white matter lesion and a decrease in the number of subcortical neurons were observed. The aim of this study was to investigate the effect of hypoxia on neurogenesis and cell survival. MATERIALS AND METHODS: In seven-day postnatal rats, the right carotid artery was ligated. The rats were incubated either in a regular normoxic chamber (control group) or in a hypoxic chamber (PVL group, 8% 02 and 92% N2 at 37°C) for 2 h. Nestin- and NeuN-positive neurons were detected by immunohistochemistry. RESULTS: The densities of nestin-immunoreactivity (IR) cells in the cerebral parietal cortex and subventricular zone were increased with hypoxia. NeuN-IR cells in the cerebral cortex were significantly decreased in the PVL group. CONCLUSION: Perinatal white matter injury induced neurogenesis, while the survival of neurons was decreased in the cerebral cortex. Copyright
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