Literature DB >> 30803964

Mutation Profile of pfdhfr and pfdhps in Plasmodium falciparum among Returned Chinese Migrant Workers from Africa.

Chao Xu1, Hui Sun1, Qingkuan Wei1, Jin Li1, Ting Xiao1, Xiangli Kong1, Yongbin Wang1, Guihua Zhao1, Longjiang Wang1, Gongzhen Liu1, Ge Yan1, Bingcheng Huang2, Kun Yin2.   

Abstract

We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum among 254 returned migrant workers in China from Africa from 2013 to 2016. High prevalences of pfdhfr (97.2%) and pfdhps (96.5%) mutations were observed. The partially resistant genotype was homogeneously distributed in Africa with a modestly high prevalence (48%), whereas the super resistant genotype was only found in West Africa with a very low frequency (1.2%). The findings provided baseline data about the molecular markers of SP resistance.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  Africa; China; Plasmodium falciparumzzm321990; SP resistance; genotype; malaria; mutation; pfdhfrzzm321990; pfdhpszzm321990

Year:  2019        PMID： 30803964      PMCID： PMC6496059          DOI： 10.1128/AAC.01927-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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Journal:  Trends Parasitol       Date:  2013-09-09

4.  Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in the Democratic Republic of the Congo: emergence of highly resistant pfdhfr/pfdhps alleles.

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9.  Recent uptake of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine is associated with increased prevalence of Pfdhfr mutations in Bobo-Dioulasso, Burkina Faso.

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Authors:  Peter Thelma Ngwa Niba; Akindeh M Nji; Marie-Solange Evehe; Innocent M Ali; Palmer Masumbe Netongo; Randolph Ngwafor; Marcel N Moyeh; Lesley Ngum Ngum; Oliva Ebie Ndum; Fon Abongwa Acho; Cyrille Mbanwi Mbu'u; Dorothy A Fosah; Barbara Atogho-Tiedeu; Olivia Achonduh-Atijegbe; Rosine Djokam-Dadjeu; Jean Paul Kengne Chedjou; Jude D Bigoga; Carole Else Eboumbou Moukoko; Anthony Ajua; Eric Achidi; Esther Tallah; Rose G F Leke; Alexis Tourgordi; Pascal Ringwald; Michael Alifrangis; Wilfred F Mbacham
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