Literature DB >> 24028889

Mapping 'partially resistant', 'fully resistant', and 'super resistant' malaria.

Inbarani Naidoo1, Cally Roper.   

Abstract

Sulfadoxine-pyrimethamine (SP) is used throughout Africa for intermittent preventive treatment (IPT) of malaria, but resistance threatens its efficacy. We found marked regional differences in the genotypes responsible for SP resistance when mapping recent surveys of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutations. In West Africa, a 'partially resistant' combination of dhfr N51I, N59R, and S108N with dhps A437G predominates, whereas in East Africa the 'fully resistant' combination of dhfr N51I, N59R, and S108N with dhps A437G+K540E is found. There are three East African foci where 'fully resistant' populations have additionally acquired dhps 581G and/or dhfr 164L to become 'super resistant'. SP-IPT in infants and pregnant women is reported to have failed in super resistant areas prompting review of SP-IPT use in affected areas.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  drug resistance; intermittent preventive treatment (IPT); malaria; sulfadoxine–pyrimethamine (SP); super resistance

Mesh：

Substances：

Year:  2013        PMID： 24028889     DOI： 10.1016/j.pt.2013.08.002

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


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