BACKGROUND AND AIMS: Intraplaque cholesterol crystal (CC) is recognized as a component of vulnerable plaques. However, the clinical characteristics of patients with CC and the impact of CC on clinical events remain unknown. METHODS: A total of 340 consecutive patients who underwent optical coherence tomography (OCT) imaging of culprit lesions were included in the study. CC was defined as a thin linear structure with high reflectivity and low signal attenuation on OCT images. The incidence of major adverse cardiovascular events (MACE) at 1-year was compared between patients with CC (CC group) and those without CC (non-CC group). MACE included cardiac death, non-fatal myocardial infarction, target vessel revascularization (TVR), and non-TVR (NTVR). RESULTS: CC was observed in 29% (n = 98) of the patients. There was no significant difference in baseline clinical characteristics between the CC and non-CC groups, other than in eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio (0.39 ± 0.29 vs. 0.47 ± 0.33, p = 0.047) and hemoglobin A1c (HbA1c) levels (6.51 ± 0.97 vs. 6.25 ± 0.87%, p = 0.016). The incidence of MACE and NTVR at 1-year was significantly higher in the CC group than in the non-CC group (15.3 vs. 7.9%, P = 0.038; 8.1 vs. 2.5%, p = 0.017). The presence of CC was significantly associated with a higher rate of 1-year MACE (odds ratio 4.78, confidential interval 2.02-10.10, p < 0.001). CONCLUSIONS: Patients with CC in the culprit lesion had higher HbA1c and lower EPA/AA than patients without CC. The 1-year clinical outcomes in patients with CC in the culprit lesion were worse than in those without CC.
BACKGROUND AND AIMS: Intraplaque cholesterol crystal (CC) is recognized as a component of vulnerable plaques. However, the clinical characteristics of patients with CC and the impact of CC on clinical events remain unknown. METHODS: A total of 340 consecutive patients who underwent optical coherence tomography (OCT) imaging of culprit lesions were included in the study. CC was defined as a thin linear structure with high reflectivity and low signal attenuation on OCT images. The incidence of major adverse cardiovascular events (MACE) at 1-year was compared between patients with CC (CC group) and those without CC (non-CC group). MACE included cardiac death, non-fatal myocardial infarction, target vessel revascularization (TVR), and non-TVR (NTVR). RESULTS: CC was observed in 29% (n = 98) of the patients. There was no significant difference in baseline clinical characteristics between the CC and non-CC groups, other than in eicosapentaenoic acid (EPA)/arachidonic acid (AA) ratio (0.39 ± 0.29 vs. 0.47 ± 0.33, p = 0.047) and hemoglobin A1c (HbA1c) levels (6.51 ± 0.97 vs. 6.25 ± 0.87%, p = 0.016). The incidence of MACE and NTVR at 1-year was significantly higher in the CC group than in the non-CC group (15.3 vs. 7.9%, P = 0.038; 8.1 vs. 2.5%, p = 0.017). The presence of CC was significantly associated with a higher rate of 1-year MACE (odds ratio 4.78, confidential interval 2.02-10.10, p < 0.001). CONCLUSIONS:Patients with CC in the culprit lesion had higher HbA1c and lower EPA/AA than patients without CC. The 1-year clinical outcomes in patients with CC in the culprit lesion were worse than in those without CC.
Authors: Mirjam Visscher; Miguel A Pleitez; Kim Van Gaalen; Ingeborg M Nieuwenhuizen-Bakker; Vasilis Ntziachristos; Gijs Van Soest Journal: Photoacoustics Date: 2022-04-11
Authors: Chongying Jin; Ryo Torii; Anantharaman Ramasamy; Vincenzo Tufaro; Callum D Little; Klio Konstantinou; Yi Ying Tan; Nathan A L Yap; Jackie Cooper; Tom Crake; Constantinos O'Mahony; Roby Rakhit; Mohaned Egred; Javed Ahmed; Grigoris Karamasis; Lorenz Räber; Andreas Baumbach; Anthony Mathur; Christos V Bourantas Journal: Front Cardiovasc Med Date: 2022-05-26
Authors: Nathalie Niyonzima; Siril S Bakke; Ida Gregersen; Sverre Holm; Øystein Sandanger; Hilde L Orrem; Bjørnar Sporsheim; Liv Ryan; Xiang Yi Kong; Tuva Børresdatter Dahl; Mona Skjelland; Kirsten Krohg Sørensen; Anne Mari Rokstad; Arne Yndestad; Eicke Latz; Lars Gullestad; Geir Ø Andersen; Jan Kristian Damås; Pål Aukrust; Tom E Mollnes; Bente Halvorsen; Terje Espevik Journal: EBioMedicine Date: 2020-09-11 Impact factor: 8.143