Literature DB >> 30801689

Adrenoceptors in white, brown, and brite adipocytes.

Bronwyn A Evans1, Jon Merlin1, Tore Bengtsson2, Dana S Hutchinson1.   

Abstract

Adrenoceptors play an important role in adipose tissue biology and physiology that includes regulating the synthesis and storage of triglycerides (lipogenesis), the breakdown of stored triglycerides (lipolysis), thermogenesis (heat production), glucose metabolism, and the secretion of adipocyte-derived hormones that can control whole-body energy homeostasis. These processes are regulated by the sympathetic nervous system through actions at different adrenoceptor subtypes expressed in adipose tissue depots. In this review, we have highlighted the role of adrenoceptor subtypes in white, brown, and brite adipocytes in both rodents and humans and have included detailed analysis of adrenoceptor expression in human adipose tissue and clonally derived adipocytes. We discuss important considerations when investigating adrenoceptor function in adipose tissue or adipocytes. LINKED ARTICLES: This article is part of a themed section on Adrenoceptors-New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc.
© 2019 The British Pharmacological Society.

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Year:  2019        PMID： 30801689      PMCID： PMC6592855          DOI： 10.1111/bph.14631

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  156 in total

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4.  Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity.

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Journal:  J Clin Invest       Date:  1998-07-15       Impact factor: 14.808

5.  Relationship of brown adipose tissue perfusion and function: a study through β2-adrenoreceptor stimulation.

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6.  Human BAT possesses molecular signatures that resemble beige/brite cells.

Authors:  Louis Z Sharp; Kosaku Shinoda; Haruya Ohno; David W Scheel; Emi Tomoda; Lauren Ruiz; Houchun Hu; Larry Wang; Zdena Pavlova; Vicente Gilsanz; Shingo Kajimura
Journal:  PLoS One       Date:  2012-11-16       Impact factor: 3.240

7.  Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype.

Authors:  Andrea Guennoun; Melissa Kazantzis; Remy Thomas; Martin Wabitsch; Daniel Tews; Konduru Seetharama Sastry; Mouaadh Abdelkarim; Vladimir Zilberfarb; Arthur Donny Strosberg; Lotfi Chouchane
Journal:  J Transl Med       Date:  2015-04-30       Impact factor: 5.531

8.  β3-Adrenergically induced glucose uptake in brown adipose tissue is independent of UCP1 presence or activity: Mediation through the mTOR pathway.

Authors:  Jessica M Olsen; Robert I Csikasz; Nodi Dehvari; Li Lu; Anna Sandström; Anette I Öberg; Jan Nedergaard; Sharon Stone-Elander; Tore Bengtsson
Journal:  Mol Metab       Date:  2017-03-30       Impact factor: 7.422

9.  High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.

Authors:  Masayuki Saito; Yuko Okamatsu-Ogura; Mami Matsushita; Kumiko Watanabe; Takeshi Yoneshiro; Junko Nio-Kobayashi; Toshihiko Iwanaga; Masao Miyagawa; Toshimitsu Kameya; Kunihiro Nakada; Yuko Kawai; Masayuki Tsujisaki
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10.  Human brown adipose tissue [(15)O]O2 PET imaging in the presence and absence of cold stimulus.

Authors:  Mueez U Din; Juho Raiko; Teemu Saari; Nobu Kudomi; Tuula Tolvanen; Vesa Oikonen; Jarmo Teuho; Hannu T Sipilä; Nina Savisto; Riitta Parkkola; Pirjo Nuutila; Kirsi A Virtanen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2016-03-19       Impact factor: 9.236
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  17 in total

Review 1.  Adrenoceptors in white, brown, and brite adipocytes.

Authors:  Bronwyn A Evans; Jon Merlin; Tore Bengtsson; Dana S Hutchinson
Journal:  Br J Pharmacol       Date:  2019-04-07       Impact factor: 8.739

Review 2.  Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue.

Authors:  Ling Yeong Chia; Bronwyn A Evans; Saori Mukaida; Tore Bengtsson; Dana S Hutchinson; Masaaki Sato
Journal:  Br J Pharmacol       Date:  2019-04-07       Impact factor: 8.739

3.  Adrenoceptors-New roles for old players.

Authors:  Martin C Michel; Richard A Bond; Roger J Summers
Journal:  Br J Pharmacol       Date:  2019-07       Impact factor: 8.739

Review 4.  Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity.

Authors:  Kong Y Chen; Robert J Brychta; Zahraa Abdul Sater; Thomas M Cassimatis; Cheryl Cero; Laura A Fletcher; Nikita S Israni; James W Johnson; Hannah J Lea; Joyce D Linderman; Alana E O'Mara; Kenneth Y Zhu; Aaron M Cypess
Journal:  J Biol Chem       Date:  2019-12-30       Impact factor: 5.157

5.  Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.

Authors:  Seongjun Byun; Chan Hyeong Lee; Hyeongmin Jeong; Hyejin Kim; Hyug Moo Kwon; Sungho Park; Kyungjae Myung; Jungeun An; Myunggon Ko
Journal:  Proc Natl Acad Sci U S A       Date:  2022-06-23       Impact factor: 12.779

Review 6.  Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential.

Authors:  Hyeonyeong Im; Ji-Hyun Park; Seowoo Im; Juhyeong Han; Kyungmin Kim; Yun-Hee Lee
Journal:  Arch Pharm Res       Date:  2021-02-07       Impact factor: 4.946

Review 7.  The Beta3 Adrenergic Receptor in Healthy and Pathological Cardiovascular Tissues.

Authors:  Lauriane Y M Michel; Charlotte Farah; Jean-Luc Balligand
Journal:  Cells       Date:  2020-12-02       Impact factor: 6.600

Review 8.  Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk.

Authors:  Kasiphak Kaikaew; Aldo Grefhorst; Jenny A Visser
Journal:  Front Endocrinol (Lausanne)       Date:  2021-04-13       Impact factor: 5.555

9.  Dopamine receptor D1- and D2-agonists do not spark brown adipose tissue thermogenesis in mice.

Authors:  Francesca-Maria Raffaelli; Julia Resch; Rebecca Oelkrug; K Alexander Iwen; Jens Mittag
Journal:  Sci Rep       Date:  2020-11-19       Impact factor: 4.379

10.  The metabolic effects of mirabegron are mediated primarily by β3 -adrenoceptors.

Authors:  Nodi Dehvari; Masaaki Sato; Muhammad Hamza Bokhari; Anastasia Kalinovich; Seungmin Ham; Jie Gao; Huong T M Nguyen; Lynda Whiting; Saori Mukaida; Jon Merlin; Ling Yeong Chia; Denise Wootten; Roger J Summers; Bronwyn A Evans; Tore Bengtsson; Dana S Hutchinson
Journal:  Pharmacol Res Perspect       Date:  2020-10
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