Literature DB >> 30799221

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model.

Yan Zhang1, Hui Tan1, Jacob D Daniels2, Fereshteh Zandkarimi3, Hengrui Liu1, Lewis M Brown3, Koji Uchida4, Owen A O'Connor5, Brent R Stockwell6.   

Abstract

Ferroptosis is a form of regulated cell death that can be induced by inhibition of the cystine-glutamate antiporter, system xc-. Among the existing system xc- inhibitors, imidazole ketone erastin (IKE) is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications. We investigated the pharmacokinetic and pharmacodynamic features of IKE in a diffuse large B cell lymphoma (DLBCL) xenograft model and demonstrated that IKE exerted an antitumor effect by inhibiting system xc-, leading to glutathione depletion, lipid peroxidation, and the induction of ferroptosis biomarkers both in vitro and in vivo. Using untargeted lipidomics and qPCR, we identified distinct features of lipid metabolism in IKE-induced ferroptosis. In addition, biodegradable polyethylene glycol-poly(lactic-co-glycolic acid) nanoparticles were employed to aid in IKE delivery and exhibited reduced toxicity compared with free IKE in a DLBCL xenograft model.
Copyright © 2019 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  DLBCL; ROS; cancer; cell death; cysteine; cystine; erastin; ferroptosis; glutathione; lipidomics; lymphoma; nanoparticle; peroxidation; system x(c)(–)

Mesh：

Substances：

Year:  2019        PMID： 30799221      PMCID： PMC6525071          DOI： 10.1016/j.chembiol.2019.01.008

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  38 in total

1.  The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents.

Authors:  Yan Yu; Yangchun Xie; Lizhi Cao; Liangchun Yang; Minghua Yang; Michael T Lotze; Herbert J Zeh; Rui Kang; Daolin Tang
Journal:  Mol Cell Oncol       Date:  2015-05-26

2.  Ferroptosis: an iron-dependent form of nonapoptotic cell death.

Authors:  Scott J Dixon; Kathryn M Lemberg; Michael R Lamprecht; Rachid Skouta; Eleina M Zaitsev; Caroline E Gleason; Darpan N Patel; Andras J Bauer; Alexandra M Cantley; Wan Seok Yang; Barclay Morrison; Brent R Stockwell
Journal:  Cell       Date:  2012-05-25       Impact factor: 41.582

3.  Sulfasalazine-induced reduction of glutathione levels in breast cancer cells: enhancement of growth-inhibitory activity of Doxorubicin.

Authors:  Vishal S Narang; Giovanni M Pauletti; Peter W Gout; Donna J Buckley; Arthur R Buckley
Journal:  Chemotherapy       Date:  2007-03-15       Impact factor: 2.544

4.  Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility.

Authors:  Marie-Helene Larraufie; Wan Seok Yang; Elise Jiang; Ajit G Thomas; Barbara S Slusher; Brent R Stockwell
Journal:  Bioorg Med Chem Lett       Date:  2015-07-14       Impact factor: 2.823

5.  Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes.

Authors:  Bjoern Chapuy; Chip Stewart; Andrew J Dunford; Jaegil Kim; Atanas Kamburov; Robert A Redd; Mike S Lawrence; Margaretha G M Roemer; Amy J Li; Marita Ziepert; Annette M Staiger; Jeremiah A Wala; Matthew D Ducar; Ignaty Leshchiner; Ester Rheinbay; Amaro Taylor-Weiner; Caroline A Coughlin; Julian M Hess; Chandra S Pedamallu; Dimitri Livitz; Daniel Rosebrock; Mara Rosenberg; Adam A Tracy; Heike Horn; Paul van Hummelen; Andrew L Feldman; Brian K Link; Anne J Novak; James R Cerhan; Thomas M Habermann; Reiner Siebert; Andreas Rosenwald; Aaron R Thorner; Matthew L Meyerson; Todd R Golub; Rameen Beroukhim; Gerald G Wulf; German Ott; Scott J Rodig; Stefano Monti; Donna S Neuberg; Markus Loeffler; Michael Pfreundschuh; Lorenz Trümper; Gad Getz; Margaret A Shipp
Journal:  Nat Med       Date:  2018-04-30       Impact factor: 53.440

6.  On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death.

Authors:  Omkar Zilka; Ron Shah; Bo Li; José Pedro Friedmann Angeli; Markus Griesser; Marcus Conrad; Derek A Pratt
Journal:  ACS Cent Sci       Date:  2017-03-07       Impact factor: 14.553

Review 7.  Emerging roles for lipids in non-apoptotic cell death.

Authors:  L Magtanong; P J Ko; S J Dixon
Journal:  Cell Death Differ       Date:  2016-03-11       Impact factor: 15.828

8.  Optimization and scale up of microfluidic nanolipomer production method for preclinical and potential clinical trials.

Authors:  Andrew Gdowski; Kaitlyn Johnson; Sunil Shah; Ignacy Gryczynski; Jamboor Vishwanatha; Amalendu Ranjan
Journal:  J Nanobiotechnology       Date:  2018-02-12       Impact factor: 10.435

9.  Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models.

Authors:  Rachid Skouta; Scott J Dixon; Jianlin Wang; Denise E Dunn; Marina Orman; Kenichi Shimada; Paul A Rosenberg; Donald C Lo; Joel M Weinberg; Andreas Linkermann; Brent R Stockwell
Journal:  J Am Chem Soc       Date:  2014-03-14       Impact factor: 15.419

Review 10.  The Role of Ferroptosis in Cancer Development and Treatment Response.

Authors:  Bin Lu; Xiao Bing Chen; Mei Dan Ying; Qiao Jun He; Ji Cao; Bo Yang
Journal:  Front Pharmacol       Date:  2018-01-12       Impact factor: 5.810
View more
  118 in total

1.  Exquisite sensitivity of adrenocortical carcinomas to induction of ferroptosis.

Authors:  Alexia Belavgeni; Stefan R Bornstein; Anne von Mässenhausen; Wulf Tonnus; Julian Stumpf; Claudia Meyer; Evelyn Othmar; Markus Latk; Waldemar Kanczkowski; Matthias Kroiss; Constanze Hantel; Christian Hugo; Martin Fassnacht; Christian G Ziegler; Andrew V Schally; Nils P Krone; Andreas Linkermann
Journal:  Proc Natl Acad Sci U S A       Date:  2019-10-14       Impact factor: 11.205

2.  Aiming at Cancer In Vivo: Ferroptosis-Inducer Delivered by Nanoparticles.

Authors:  Junmei Yi; Alexander M Minikes; Xuejun Jiang
Journal:  Cell Chem Biol       Date:  2019-05-16       Impact factor: 8.116

3.  Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis.

Authors:  Junmei Yi; Jiajun Zhu; Jiao Wu; Craig B Thompson; Xuejun Jiang
Journal:  Proc Natl Acad Sci U S A       Date:  2020-11-23       Impact factor: 11.205

Review 4.  Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis.

Authors:  Hülya Bayır; Tamil S Anthonymuthu; Yulia Y Tyurina; Sarju J Patel; Andrew A Amoscato; Andrew M Lamade; Qin Yang; Georgy K Vladimirov; Caroline C Philpott; Valerian E Kagan
Journal:  Cell Chem Biol       Date:  2020-04-09       Impact factor: 8.116

Review 5.  Broadening horizons: the role of ferroptosis in cancer.

Authors:  Xin Chen; Rui Kang; Guido Kroemer; Daolin Tang
Journal:  Nat Rev Clin Oncol       Date:  2021-01-29       Impact factor: 66.675

Review 6.  Progress in Understanding Ferroptosis and Challenges in Its Targeting for Therapeutic Benefit.

Authors:  Yilong Zou; Stuart L Schreiber
Journal:  Cell Chem Biol       Date:  2020-04-16       Impact factor: 8.116

Review 7.  The Chemistry and Biology of Ferroptosis.

Authors:  Brent R Stockwell; Xuejun Jiang
Journal:  Cell Chem Biol       Date:  2020-04-16       Impact factor: 8.116

8.  Cysteine depletion induces pancreatic tumor ferroptosis in mice.

Authors:  Michael A Badgley; Daniel M Kremer; H Carlo Maurer; Kathleen E DelGiorno; Ho-Joon Lee; Vinee Purohit; Irina R Sagalovskiy; Alice Ma; Jonathan Kapilian; Christina E M Firl; Amanda R Decker; Steve A Sastra; Carmine F Palermo; Leonardo R Andrade; Peter Sajjakulnukit; Li Zhang; Zachary P Tolstyka; Tal Hirschhorn; Candice Lamb; Tong Liu; Wei Gu; E Scott Seeley; Everett Stone; George Georgiou; Uri Manor; Alina Iuga; Geoffrey M Wahl; Brent R Stockwell; Costas A Lyssiotis; Kenneth P Olive
Journal:  Science       Date:  2020-04-03       Impact factor: 47.728

9.  Small Molecule Regulators of Ferroptosis.

Authors:  Sylvain Debieu; Stéphanie Solier; Ludovic Colombeau; Antoine Versini; Fabien Sindikubwabo; Alison Forrester; Sebastian Müller; Tatiana Cañeque; Raphaël Rodriguez
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

10.  Overcoming Therapeutic Challenges for Pancreatic Ductal Adenocarcinoma with xCT Inhibitors.

Authors:  Milica Vucetic; Boutaina Daher; Shamir Cassim; Scott Parks; Jacques Pouyssegur
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.