Literature DB >> 30798386

The additive hazard estimator is consistent for continuous-time marginal structural models.

Pål C Ryalen1, Mats J Stensrud2, Kjetil Røysland2.   

Abstract

Marginal structural models (MSMs) allow for causal analysis of longitudinal data. The standard MSM is based on discrete time models, but the continuous-time MSM is a conceptually appealing alternative for survival analysis. In applied analyses, it is often assumed that the theoretical treatment weights are known, but these weights are usually unknown and must be estimated from the data. Here we provide a sufficient condition for continuous-time MSM to be consistent even when the weights are estimated, and we show how additive hazard models can be used to estimate such weights. Our results suggest that continuous-time weights perform better than IPTW when the underlying process is continuous. Furthermore, we may wish to transform effect estimates of hazards to other scales that are easier to interpret causally. We show that a general transformation strategy can be used on weighted cumulative hazard estimates to obtain a range of other parameters in survival analysis, and explain how this strategy can be applied on data using our R packages ahw and transform.hazards.

Entities:  

Keywords:  Additive hazard models; Causal inference in survival analysis; Continuous time marginal structural models; Continuous time weights

Mesh:

Year:  2019        PMID: 30798386     DOI: 10.1007/s10985-019-09468-y

Source DB:  PubMed          Journal:  Lifetime Data Anal        ISSN: 1380-7870            Impact factor:   1.588


  9 in total

1.  Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men.

Authors:  M A Hernán; B Brumback; J M Robins
Journal:  Epidemiology       Date:  2000-09       Impact factor: 4.822

2.  Marginal structural models and causal inference in epidemiology.

Authors:  J M Robins; M A Hernán; B Brumback
Journal:  Epidemiology       Date:  2000-09       Impact factor: 4.822

3.  Does Cox analysis of a randomized survival study yield a causal treatment effect?

Authors:  Odd O Aalen; Richard J Cook; Kjetil Røysland
Journal:  Lifetime Data Anal       Date:  2015-06-24       Impact factor: 1.588

4.  The probability of causation under a stochastic model for individual risk.

Authors:  J Robins; S Greenland
Journal:  Biometrics       Date:  1989-12       Impact factor: 2.571

5.  Exploring Selection Bias by Causal Frailty Models: The Magnitude Matters.

Authors:  Mats Julius Stensrud; Morten Valberg; Kjetil Røysland; Odd O Aalen
Journal:  Epidemiology       Date:  2017-05       Impact factor: 4.822

6.  Causal inference in continuous time: an example on prostate cancer therapy.

Authors:  Pål Christie Ryalen; Mats Julius Stensrud; Sophie Fosså; Kjetil Røysland
Journal:  Biostatistics       Date:  2018-08-16       Impact factor: 5.899

7.  Simulating from marginal structural models with time-dependent confounding.

Authors:  W G Havercroft; V Didelez
Journal:  Stat Med       Date:  2012-07-23       Impact factor: 2.373

8.  The hazards of hazard ratios.

Authors:  Miguel A Hernán
Journal:  Epidemiology       Date:  2010-01       Impact factor: 4.822

9.  Constructing inverse probability weights for marginal structural models.

Authors:  Stephen R Cole; Miguel A Hernán
Journal:  Am J Epidemiol       Date:  2008-08-05       Impact factor: 4.897

  9 in total
  1 in total

1.  Simulating longitudinal data from marginal structural models using the additive hazard model.

Authors:  Ruth H Keogh; Shaun R Seaman; Jon Michael Gran; Stijn Vansteelandt
Journal:  Biom J       Date:  2021-05-13       Impact factor: 2.207

  1 in total

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