| Literature DB >> 30796930 |
Renjin Zheng1, Qiumei Guan2, Mi Zheng3, Zongxiu Huang4, Hongnan Huang4, Wusheng Fu4, Shouer Lin4, Yan Yang4.
Abstract
The presence of paralytic shellfish poisoning (PSP), diarrhetic Shellfish Poisoning (DSP), tetrodotoxin (TTX) and its analogues (11-oxoTTX, 4.9-anhydro-11-oxoTTX, 4.9-anhydroTTX, 5-deoxyTTX, 5.11-dideoxyTTX, 5.6.11-trideoxyTTX and 4.9-anhydro-5.6.11-trideoxy TTX) were initially investigated in Carcinoscorpius rotundicauda collected from south China with Liquid chromatography-tandem mass spectrometry (LC-MS-MS) and mouse bioassay. The TTX toxicity was 10.8 ± 3.9 MU/g muscle, 6.3 ± 0.6 MU/g viscera and 6.3 ± 0.6 MU/g eggs in mean value. Merely dcGTX2 and dcSTX were detected in ten Specimens, ranging from 0.01 to 0.77 μg/g. Analyses suggested that these Carcinoscorpius rotundicauda contain TTX and its analogues as the major toxin and PSPs as the minor, respectively. Besides, no DSPs were found.Entities:
Keywords: Carcinoscorpius rotundicauda; LC-MS/MS(1); Mangrove horseshoe crab; Paralytic shellfish poisoning; Tetrodotoxin
Mesh：
Substances：
Year: 2019 PMID： 30796930 DOI： 10.1016/j.toxicon.2019.02.002
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033