| Literature DB >> 30795971 |
Stephanie Dobersch1, Karla Rubio1, Guillermo Barreto2.
Abstract
Accumulation of mutations causing aberrant changes in the genome promotes cancer. However, mutations do not occur in every cancer subtype, suggesting additional events that trigger cancer. Chromatin rearrangements initiated by pioneer factors and architectural proteins are key events occurring before cancer-related genes are expressed. Both protein groups are also master regulators of important processes during embryogenesis. Several publications demonstrated that embryonic gene expression signatures are reactivated during cancer. This review article highlights current knowledge on pioneer factors and architectural proteins mediating chromatin rearrangements, which are the backbone of embryonic expression signatures promoting malignant transformation. Understanding chromatin rearrangements inducing embryonic expression signatures in adult cells might be the key to novel therapeutic approaches against cancers subtypes that arise without genomic mutations.Entities:
Keywords: architectural proteins; cancer; embryonic; expression signature; pioneer factors
Mesh：
Substances：
Year: 2019 PMID： 30795971 DOI： 10.1016/j.molmed.2019.01.008
Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951