Lin-Lin Yang1, Dong Zhao2, Lan-Lan Kong1, Ya-Qi Sun1, Zi-Yang Wang1, Yuan-Yuan Gao1, Na Li1, Lin Lu3, Le Shi4, Xue-Yi Wang1, Yu-Mei Wang5. 1. Institute of Mental Health, Hebei Medical University, Shijiazhuang, 050031, China; Department of Psychiatry, First Hospital of Hebei Medical University, Shijiazhuang, 050031, China. 2. Department of Psychiatry, Eighth Hospital of Shijiazhuang, Shijiazhuang, 050080, China. 3. Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospital, Peking University, Beijing, 100191, China. Electronic address: linlu@bjmu.edu.cn. 4. Institute of Mental Health, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health and Peking University Sixth Hospital, Peking University, Beijing, 100191, China. 5. Institute of Mental Health, Hebei Medical University, Shijiazhuang, 050031, China; Department of Psychiatry, First Hospital of Hebei Medical University, Shijiazhuang, 050031, China. Electronic address: wangym@bjmu.edu.cn.
Abstract
BACKGROUND:Patients with bipolar disorder (BD) present widespread and significant neurocognitive impairments during all stages of the disorder. Repetitive transcranial magnetic stimulation (rTMS) has been used to improve clinical outcomes in common psychiatric diseases, such as depression, anxiety disorders, schizophrenia, and BD. Whether rTMS can improve cognitive function in BD patients remains unclear. The present study explored the regulatory effects of rTMS on cognitive function in patients with BD. METHODS:Fifty-two eligible subjects with BD were randomly assigned to receive active or sham rTMS via high-speed magnetic stimulator with a figure-of-eight coil for 10 consecutive days. In the active rTMS group, a total of 25,000 stimuli were applied over the left dorsolateral prefrontal cortex at 110% of the motor threshold. The sham group received corresponding sham stimulation. Clinical manifestations and cognitive functions were assessed using a modified 24-item Hamilton Depression Rating Scale (HDRS), the Young Mania Rating Scale (YMRS), and the MATRICS Consensus Cognitive Battery (MCCB). RESULTS: Ten consecutive days of high-frequency active rTMS improved scores on the Wechsler Memory Scale-III Spatial Span, and the MCCB Category Fluency subtest, without intolerable adverse effects. No significant differences in HDRS or YMRS scores were found between groups. LIMITATIONS: No follow-up after the intervention. The effect of the drug on cognitive function in subjects was not excluded. CONCLUSIONS:Short-term rTMS can improve cognitive function in BD patients.
RCT Entities:
BACKGROUND:Patients with bipolar disorder (BD) present widespread and significant neurocognitive impairments during all stages of the disorder. Repetitive transcranial magnetic stimulation (rTMS) has been used to improve clinical outcomes in common psychiatric diseases, such as depression, anxiety disorders, schizophrenia, and BD. Whether rTMS can improve cognitive function in BD patients remains unclear. The present study explored the regulatory effects of rTMS on cognitive function in patients with BD. METHODS: Fifty-two eligible subjects with BD were randomly assigned to receive active or sham rTMS via high-speed magnetic stimulator with a figure-of-eight coil for 10 consecutive days. In the active rTMS group, a total of 25,000 stimuli were applied over the left dorsolateral prefrontal cortex at 110% of the motor threshold. The sham group received corresponding sham stimulation. Clinical manifestations and cognitive functions were assessed using a modified 24-item Hamilton Depression Rating Scale (HDRS), the Young Mania Rating Scale (YMRS), and the MATRICS Consensus Cognitive Battery (MCCB). RESULTS: Ten consecutive days of high-frequency active rTMS improved scores on the Wechsler Memory Scale-III Spatial Span, and the MCCB Category Fluency subtest, without intolerable adverse effects. No significant differences in HDRS or YMRS scores were found between groups. LIMITATIONS: No follow-up after the intervention. The effect of the drug on cognitive function in subjects was not excluded. CONCLUSIONS: Short-term rTMS can improve cognitive function in BD patients.
Authors: Kamilla W Miskowiak; Ida Seeberg; Mette B Jensen; Vicent Balanzá-Martínez; Caterina Del Mar Bonnin; Christopher R Bowie; Andre F Carvalho; Annemieke Dols; Katie Douglas; Peter Gallagher; Gregor Hasler; Beny Lafer; Kathryn E Lewandowski; Carlos López-Jaramillo; Anabel Martinez-Aran; Roger S McIntyre; Richard J Porter; Scot E Purdon; Ayal Schaffer; Paul Stokes; Tomiki Sumiyoshi; Ivan J Torres; Tamsyn E Van Rheenen; Lakshmi N Yatham; Allan H Young; Lars V Kessing; Katherine E Burdick; Eduard Vieta Journal: Bipolar Disord Date: 2022-02-24 Impact factor: 5.345