| Literature DB >> 30794777 |
Shashi Gujar1, John Bell2, Jean-Simon Diallo2.
Abstract
Oncolytic viruses (OVs) preferentially infect and kill cancer cells without harming normal cells. OVs can revert cancer-associated immune suppression and initiate clinically meaningful antitumor immune responses. OVs and their resultant immunological events can act at both primary and metastatic sites. Thus, OVs can be exploited for cancer gene therapies and immunotherapies alone or in combination with other interventions, including immune checkpoint blockade.Entities:
Year: 2019 PMID: 30794777 DOI: 10.1016/j.cell.2019.01.051
Source DB: PubMed Journal: Cell ISSN: 0092-8674 Impact factor: 41.582