Amanda J F Tamman1, Janitza L Montalvo-Ortiz2, Steven M Southwick3, John H Krystal3, Becca R Levy4, Robert H Pietrzak5. 1. Department of Psychology (AJFT), St. John's University, Queens, NY. Electronic address: amanda.tamman17@my.stjohns.edu. 2. Department of Psychiatry (JLM, SMS, JHK, RHP), Yale University School of Medicine, New Haven, CT. 3. Department of Psychiatry (JLM, SMS, JHK, RHP), Yale University School of Medicine, New Haven, CT; Clinical Neurosciences Division (SMS, JHK, RHP), U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT. 4. Yale School of Public Health (BRL, RHP), New Haven, CT. 5. Department of Psychiatry (JLM, SMS, JHK, RHP), Yale University School of Medicine, New Haven, CT; Clinical Neurosciences Division (SMS, JHK, RHP), U.S. Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT; Yale School of Public Health (BRL, RHP), New Haven, CT.
Abstract
OBJECTIVE: The aim of this study was to identify how a broad range of sociodemographic, military, health, and psychosocial factors relate to accelerated DNA methylation aging (Δage) in a large, contemporary, nationally representative sample of male U.S. veterans. METHODS: Data were analyzed from a sample of U.S. male European-American veterans who participated in the National Health and Resilience in Veterans Study (N = 1,135). RESULTS: Psychosocial factors of lifetime trauma burden, child sexual trauma, and negative beliefs about aging were independently associated with Δage. Three health variables-diabetes, hypertension, and body mass index-emerged as additional correlates of Δage. CONCLUSION: Results of the study build on prior work demonstrating associations between accelerated DNA methylation aging and traumatic stress, highlighting a role for child sexual abuse in particular. They further underscore the importance of targeting negative beliefs about aging, which are modifiable, in prevention efforts designed to forestall accelerated DNA methylation aging.
OBJECTIVE: The aim of this study was to identify how a broad range of sociodemographic, military, health, and psychosocial factors relate to accelerated DNA methylation aging (Δage) in a large, contemporary, nationally representative sample of male U.S. veterans. METHODS: Data were analyzed from a sample of U.S. male European-American veterans who participated in the National Health and Resilience in Veterans Study (N = 1,135). RESULTS:Psychosocial factors of lifetime trauma burden, childsexual trauma, and negative beliefs about aging were independently associated with Δage. Three health variables-diabetes, hypertension, and body mass index-emerged as additional correlates of Δage. CONCLUSION: Results of the study build on prior work demonstrating associations between accelerated DNA methylation aging and traumatic stress, highlighting a role for childsexual abuse in particular. They further underscore the importance of targeting negative beliefs about aging, which are modifiable, in prevention efforts designed to forestall accelerated DNA methylation aging.
Authors: Brienna M Fogle; Jack Tsai; Natalie Mota; Ilan Harpaz-Rotem; John H Krystal; Steven M Southwick; Robert H Pietrzak Journal: Front Psychiatry Date: 2020-12-09 Impact factor: 4.157
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