Ruud J L F Loffeld1, Sandra A Srbjlin1. 1. Department of Gastroenterology and Nuclear Medicine, Zaans Medisch Centrum, Zaandam, The Netherlands.
Abstract
BACKGROUND: Fludeoxyglucose positron-emission tomography (FDG-PET) shows colic uptake regularly. Complementary colonoscopy is done. Aim: study the findings of colonoscopy. METHODS: All consecutive scans in 5 years were studied. Focal FDG uptake in colon and/or rectum were scored as + or ++. Clinical files and endoscopy reports were studied for final diagnosis. RESULTS: Focal FDG uptake was noted in 173 out of 2,075 scans (8.4%). Focal FDG activity was judged ++ in 73 patients (42.2%) and + in 100 (57.8%). The majority of colorectal cancers scored ++. Patients with ++ activity underwent or had undergone significantly more often a colonoscopy compared with patients with + activity, 82% versus 65% (P=0.02). FDG PET/CT was false positive with respect to polyp(s) or cancer in 13 cases (22%) of ++ FGD activity and in 38 cases of + FDG (P<0.001). In 25 patients a total of 69 polyps were not FDG avid. CONCLUSIONS: FDG-PET scanning is a useful tool in oncology. However, false-positive and false-negative findings with respect to colonic uptake are present in a significant number of patients. If the clinical condition and the potential prognosis allows the performance of colonoscopy this procedure should be done.
BACKGROUND: Fludeoxyglucose positron-emission tomography (FDG-PET) shows colic uptake regularly. Complementary colonoscopy is done. Aim: study the findings of colonoscopy. METHODS: All consecutive scans in 5 years were studied. Focal FDG uptake in colon and/or rectum were scored as + or ++. Clinical files and endoscopy reports were studied for final diagnosis. RESULTS: Focal FDG uptake was noted in 173 out of 2,075 scans (8.4%). Focal FDG activity was judged ++ in 73 patients (42.2%) and + in 100 (57.8%). The majority of colorectal cancers scored ++. Patients with ++ activity underwent or had undergone significantly more often a colonoscopy compared with patients with + activity, 82% versus 65% (P=0.02). FDG PET/CT was false positive with respect to polyp(s) or cancer in 13 cases (22%) of ++ FGD activity and in 38 cases of + FDG (P<0.001). In 25 patients a total of 69 polyps were not FDG avid. CONCLUSIONS: FDG-PET scanning is a useful tool in oncology. However, false-positive and false-negative findings with respect to colonic uptake are present in a significant number of patients. If the clinical condition and the potential prognosis allows the performance of colonoscopy this procedure should be done.
Authors: Ehab M Kamel; Miriam Thumshirn; Kaspar Truninger; Marc Schiesser; Michael Fried; Barbara Padberg; Didier Schneiter; Sandro J Stoeckli; Gustav K von Schulthess; Katrin D M Stumpe Journal: J Nucl Med Date: 2004-11 Impact factor: 10.057
Authors: S T Lee; T Tan; A M T Poon; H B Toh; S Gill; S U Berlangieri; E Kraft; A J Byrne; K Pathmaraj; G J O'Keefe; N Tebbutt; A M Scott Journal: Mol Imaging Biol Date: 2007-11-10 Impact factor: 3.488
Authors: James W Fletcher; Benjamin Djulbegovic; Heloisa P Soares; Barry A Siegel; Val J Lowe; Gary H Lyman; R Edward Coleman; Richard Wahl; John Christopher Paschold; Norbert Avril; Lawrence H Einhorn; W Warren Suh; David Samson; Dominique Delbeke; Mark Gorman; Anthony F Shields Journal: J Nucl Med Date: 2008-02-20 Impact factor: 10.057