Xing Fan1, Hongyan Wang1, Liangdan Sun1, Xiaodong Zheng2, Xianyong Yin2, Xianbo Zuo2, Qian Peng3, Kristopher A Standish4, Hui Cheng1, Yaohua Zhang5, Zaixing Wang1, Fengli Xiao1, Sen Yang1, Xuejun Zhang1, Nicholas J Schork6. 1. Departmentof Dermatology, Anhui Medical University, The First Affiliated Hospital ofAnhui Medical University, 218 Jixi Road, Shushan District, Hefei City, Anhui, 230022, PR China. 2. Instituteof Dermatology, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei City, Anhui, 230032, PR China. 3. Molecular& Cellular Neuroscience, The Scripps Research Institute, 10550 North TorreyPines Road, La Jolla, CA 92037, USA. 4. Genomics, Bioinformatics, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA92037, USA. 5. Instituteof Dermatology, Department of Dermatology, Huashan Hospital, Fudan University, No.12, Middle Urumqi Road, Shanghai, 200040, PR China. 6. HumanBiology, J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.
Abstract
AIM: A genomic region on 5q33.3 lies between and encompasses the IL12B and PTTG1 genes, and contains many potential psoriasis causal variants. We aimed to further examine the influence of variants in and around this region. MATERIALS & METHODS: We used least absolute shrinkage and selection operator (LASSO)-based regression analysis to assess independent contributions of 2171 variants to psoriasis susceptibility and tested them for association with different clinical psoriasis subtypes. RESULTS: We found that ADRA1B gene variants contribute to psoriasis in Chinese population. ADRA1B gene variants have a stronger association with moderate-to-severe disease group and an earlier age at onset of psoriasis than IL-12B and PTTG1 variants. CONCLUSION: The association of variants in the ADRA1B gene with psoriasis could explain why variants in the IL-12B, ADRA1B and PTTG1 gene regions are associated with psoriasis.
AIM: A genomic region on 5q33.3 lies between and encompasses the IL12B and PTTG1 genes, and contains many potential psoriasis causal variants. We aimed to further examine the influence of variants in and around this region. MATERIALS & METHODS: We used least absolute shrinkage and selection operator (LASSO)-based regression analysis to assess independent contributions of 2171 variants to psoriasis susceptibility and tested them for association with different clinical psoriasis subtypes. RESULTS: We found that ADRA1B gene variants contribute to psoriasis in Chinese population. ADRA1B gene variants have a stronger association with moderate-to-severe disease group and an earlier age at onset of psoriasis than IL-12B and PTTG1 variants. CONCLUSION: The association of variants in the ADRA1B gene with psoriasis could explain why variants in the IL-12B, ADRA1B and PTTG1 gene regions are associated with psoriasis.
Authors: Eva Ellinghaus; David Ellinghaus; Philip E Stuart; Rajan P Nair; Sophie Debrus; John V Raelson; Majid Belouchi; Hélène Fournier; Claudia Reinhard; Jun Ding; Yun Li; Trilokraj Tejasvi; Johann Gudjonsson; Stefan W Stoll; John J Voorhees; Sylviane Lambert; Stephan Weidinger; Bernadette Eberlein; Manfred Kunz; Proton Rahman; Dafna D Gladman; Christian Gieger; H Erich Wichmann; Tom H Karlsen; Gabriele Mayr; Mario Albrecht; Dieter Kabelitz; Ulrich Mrowietz; Gonçalo R Abecasis; James T Elder; Stefan Schreiber; Michael Weichenthal; Andre Franke Journal: Nat Genet Date: 2010-10-17 Impact factor: 38.330
Authors: Ying Liu; Cynthia Helms; Wilson Liao; Lisa C Zaba; Shenghui Duan; Jennifer Gardner; Carol Wise; Andrew Miner; M J Malloy; Clive R Pullinger; John P Kane; Scott Saccone; Jane Worthington; Ian Bruce; Pui-Yan Kwok; Alan Menter; James Krueger; Anne Barton; Nancy L Saccone; Anne M Bowcock Journal: PLoS Genet Date: 2008-03-28 Impact factor: 5.917
Authors: Rajan P Nair; Kristina Callis Duffin; Cynthia Helms; Jun Ding; Philip E Stuart; David Goldgar; Johann E Gudjonsson; Yun Li; Trilokraj Tejasvi; Bing-Jian Feng; Andreas Ruether; Stefan Schreiber; Michael Weichenthal; Dafna Gladman; Proton Rahman; Steven J Schrodi; Sampath Prahalad; Stephen L Guthery; Judith Fischer; Wilson Liao; Pui-Yan Kwok; Alan Menter; G Mark Lathrop; Carol A Wise; Ann B Begovich; John J Voorhees; James T Elder; Gerald G Krueger; Anne M Bowcock; Gonçalo R Abecasis Journal: Nat Genet Date: 2009-01-25 Impact factor: 38.330
Authors: Francesca Capon; Marie-José Bijlmakers; Natalie Wolf; Maria Quaranta; Ulrike Huffmeier; Michael Allen; Kirsten Timms; Victor Abkevich; Alexander Gutin; Rhodri Smith; Richard B Warren; Helen S Young; Jane Worthington; A David Burden; Christopher E M Griffiths; Adrian Hayday; Frank O Nestle; Andre Reis; Jerry Lanchbury; Jonathan N Barker; Richard C Trembath Journal: Hum Mol Genet Date: 2008-03-25 Impact factor: 6.150