Simultaneous voltammetric determination of acetaminophen and isoniazid using MXene modified screen-printed electrode.

Determination of hepatotoxic drugs is critical for both clinical diagnosis and quantity control of their pharmaceutical formulations. In this work, a facile and sensitive sensor based on MXene modified screen-printed electrode (MXene/SPE) has been developed for detection of acetaminophen (ACOP) and isoniazid (INZ), which are two commonly used drugs but might induce liver damage in certain circumstances. MXene showed excellent electrocatalytic activity toward the oxidation of ACOP and INZ compared with bare SPE in 0.1 M H2SO4, and the separated oxidation peak potentials ensured simultaneous detection of the targets with wide linear ranges from 0.25 to 2000 μM for ACOP and 0.1-4.6 mM for INZ. The detection limits of ACOP and INZ were 0.048 μM and 0.064 mM, respectively. (S/N = 3). MXene/SPE exhibits good stability, reproducibility and repeatability, and the method has been successfully applied for detection of ACOP and INZ in their pharmaceutical and biological samples with satisfactory recovery.