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Literature DB >> 30778233

SignalP 5.0 improves signal peptide predictions using deep neural networks.

José Juan Almagro Armenteros¹, Konstantinos D Tsirigos^1,2,3,4, Casper Kaae Sønderby⁵, Thomas Nordahl Petersen⁶, Ole Winther^5,7, Søren Brunak^1,8, Gunnar von Heijne^2,3, Henrik Nielsen⁹.

Abstract

Signal peptides (SPs) are short amino acid sequences in the amino terminus of many newly synthesized proteins that target proteins into, or across, membranes. Bioinformatic tools can predict SPs from amino acid sequences, but most cannot distinguish between various types of signal peptides. We present a deep neural network-based approach that improves SP prediction across all domains of life and distinguishes between three types of prokaryotic SPs.

Entities: Chemical

Mesh：

Substances：

Year: 2019 PMID： 30778233 DOI： 10.1038/s41587-019-0036-z

Source DB: PubMed Journal: Nat Biotechnol ISSN： 1087-0156 Impact factor: 54.908

1 in total

1. Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol.

Authors: K Sankaran; H C Wu
Journal: J Biol Chem Date: 1994-08-05 Impact factor: 5.157

1 in total

981 in total

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SignalP 5.0 improves signal peptide predictions using deep neural networks.

1. Lipid modification of bacterial prolipoprotein. Transfer of diacylglyceryl moiety from phosphatidylglycerol.

1. Metagenomic analysis of the human microbiome reveals the association between the abundance of gut bile salt hydrolases and host health.

2. A novel esterase DacA_pva from Comamonas sp. strain NyZ500 with deacetylation activity for acetylated polymer polyvinyl alcohol.

3. Cultivable, Host-Specific Bacteroidetes Symbionts Exhibit Diverse Polysaccharolytic Strategies.

4. Proteomic Characterization of Lignocellulolytic Enzymes Secreted by the Insect-Associated Fungus Daldinia decipiens oita, Isolated from a Forest in Northern Japan.

5. The C-Terminal Domain of Clostridioides difficile TcdC Is Exposed on the Bacterial Cell Surface.

6. Chromosome-scale genome assembly of sweet cherry (Prunus avium L.) cv. Tieton obtained using long-read and Hi-C sequencing.

7. An Unexpected Role for the Periplasmic Phosphatase PhoN in the Salvage of B₆ Vitamers in Salmonella enterica.

8. Plasmopara viticola effector PvRXLR53 suppresses innate immunity in Nicotiana benthamiana.

9. Prediction of Burkholderia pseudomallei DsbA substrates identifies potential virulence factors and vaccine targets.

10. Regulators of an ancient polyphenism evolved through episodic protein divergence and parallel gene radiations.