Literature DB >> 30777890

Impact of single phase CT angiography collateral status on functional outcome over time: results from the MR CLEAN Registry.

Maxim Jhl Mulder1, Robert-Jan B Goldhoorn2, Ido R van den Wijngaard3, Charles Blm Majoie4, Ivo Gh Jansen4, Anna Mm Boers4,5, Adriaan Cgm van Es6, Lonneke Sf Yo7, Jeannette Hofmeijer8, Jasper M Martens9, Marianne Aa van Walderveen10, Bas Fw van der Kallen3, Sjoerd Fm Jenniskens11, Kilian M Treurniet4, Henk A Marquering4,5, Marieke Es Sprengers4, Wouter J Schonewille12, Joost Cj Bot13, Geert J Lycklama A Nijeholt14, Hester F Lingsma15, David S Liebeskind16, Jelis Boiten3, Jan Albert Vos17, Yvo Bwem Roos18, Robert J van Oostenbrugge2, Aad van der Lugt6, Wim H van Zwam19, Diederik Wj Dippel1.   

Abstract

BACKGROUND: Collateral status modified the effect of endovascular treatment (EVT) for stroke in several randomized trials. We assessed the association between collaterals and functional outcome in EVT treated patients and investigated if this association is time dependent.
METHODS: We included consecutive patients from the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in The Netherlands (MR CLEAN) Registry (March 2014-June 2016) with an anterior circulation large vessel occlusion undergoing EVT. Functional outcome was measured on the modified Rankin Scale (mRS) at 90 days. We investigated the association between collaterals and mRS in the MR CLEAN Registry with ordinal logistic regression and if this association was time dependent with an interaction term. Additionally, we determined modification of EVT effect by collaterals compared with MR CLEAN controls, and also investigated if this was time dependent with multiplicative interaction terms.
RESULTS: 1412 patients were analyzed. Functional independence (mRS score of 0-2) was achieved in 13% of patients with grade 0 collaterals, in 27% with grade 1, in 46% with grade 2, and in 53% with grade 3. Collaterals were significantly associated with mRS (adjusted common OR 1.5 (95% CI 1.4 to 1.7)) and significantly modified EVT benefit (P=0.04). None of the effects were time dependent. Better collaterals corresponded to lower mortality (P<0.001), but not to lower rates of symptomatic intracranial hemorrhage (P=0.14).
CONCLUSION: In routine clinical practice, better collateral status is associated with better functional outcome and greater treatment benefit in EVT treated acute ischemic stroke patients, independent of time to treatment. Within the 6 hour time window, a substantial proportion of patients with absent and poor collaterals can still achieve functional independence. © Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  ct angiography; intervention; stroke

Mesh：

Year:  2019        PMID： 30777890     DOI： 10.1136/neurintsurg-2018-014619

Source DB:  PubMed          Journal:  J Neurointerv Surg        ISSN： 1759-8478            Impact factor:   5.836


  9 in total

1.  Reduced Leukoaraiosis, Noncardiac Embolic Stroke Etiology, and Shorter Thrombus Length Indicate Good Leptomeningeal Collateral Flow in Embolic Large-Vessel Occlusion.

Authors:  T Hashimoto; T Kunieda; T Honda; F Scalzo; L Ali; J D Hinman; N M Rao; M Nour; M Bahr-Hosseini; J L Saver; R Raychev; D Liebeskind
Journal:  AJNR Am J Neuroradiol       Date:  2021-11-18       Impact factor: 3.825

2.  Time Since Stroke Onset, Quantitative Collateral Score, and Functional Outcome After Endovascular Treatment for Acute Ischemic Stroke.

Authors:  Simone M Uniken Venema; Lennard Wolff; Sophie A van den Berg; Hendrik Reinink; Sven P R Luijten; Hester F Lingsma; Henk A Marquering; Anna M M Boers; Joost Bot; Sebastiaan Hammer; Paul J Nederkoorn; Yvo B W E M Roos; Charles B L M Majoie; Jan Willem Dankbaar; Aad van der Lugt; H Bart van der Worp
Journal:  Neurology       Date:  2022-08-02       Impact factor: 11.800

3.  Collateral Capacity Assessment : Robustness and Interobserver Agreement of Two Grading Scales and Agreement with Quantitative Scoring.

Authors:  Wenjin Yang; Jazba Soomro; Ivo G H Jansen; Aashish Venkatesh; Albert J Yoo; Demetrius Lopes; Ludo F M Beenen; Bart J Emmer; Charles B L M Majoie; Henk A Marquering
Journal:  Clin Neuroradiol       Date:  2022-09-26       Impact factor: 3.156

4.  Occult blood flow patterns distal to an occluded artery in acute ischemic stroke.

Authors:  Nerea Arrarte Terreros; Bettine G van Willigen; Wera S Niekolaas; Manon L Tolhuisen; Josje Brouwer; Jonathan M Coutinho; Ludo Fm Beenen; Charles Blm Majoie; Ed van Bavel; Henk A Marquering
Journal:  J Cereb Blood Flow Metab       Date:  2021-09-22       Impact factor: 6.960

5.  Association of Ischemic Core Imaging Biomarkers With Post-Thrombectomy Clinical Outcomes in the MR CLEAN Registry.

Authors:  Miou S Koopman; Jan W Hoving; Manon Kappelhof; Olvert A Berkhemer; Ludo F M Beenen; Wim H van Zwam; Hugo W A M de Jong; Jan Willem Dankbaar; Diederik W J Dippel; Jonathan M Coutinho; Henk A Marquering; Bart J Emmer; Charles B L M Majoie
Journal:  Front Neurol       Date:  2022-01-10       Impact factor: 4.003

6.  Clinical Implications of Prominent Cortical Vessels on Susceptibility-Weighted Imaging in Acute Ischemic Stroke Patients Treated with Recanalization Therapy.

Authors:  Misun Oh; Minwoo Lee
Journal:  Brain Sci       Date:  2022-01-29

7.  Collateral Status and Clinical Outcomes after Mechanical Thrombectomy in Patients with Anterior Circulation Occlusion.

Authors:  Yuzhu Xu; Songtao Guo; Hao Jiang; Hui Han; Jian Sun; Xi Wu
Journal:  J Healthc Eng       Date:  2022-01-25       Impact factor: 2.682

8.  Diagnostic performance of an algorithm for automated large vessel occlusion detection on CT angiography.

Authors:  Sven P R Luijten; Lennard Wolff; Martijne H C Duvekot; Pieter-Jan van Doormaal; Walid Moudrous; Henk Kerkhoff; Geert J Lycklama A Nijeholt; Reinoud P H Bokkers; Lonneke S F Yo; Jeannette Hofmeijer; Wim H van Zwam; Adriaan C G M van Es; Diederik W J Dippel; Bob Roozenbeek; Aad van der Lugt
Journal:  J Neurointerv Surg       Date:  2021-08-19       Impact factor: 8.572

9.  Jet-Like Appearance in Angiography as a Predictive Image Marker for the Occlusion of Intracranial Atherosclerotic Stenosis.

Authors:  Xing Jin; Feina Shi; Yigang Chen; Xu Zheng; Jinhua Zhang
Journal:  Front Neurol       Date:  2020-10-30       Impact factor: 4.003
  9 in total

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