| Literature DB >> 30776694 |
Fatima Arshad1, Mohemmed Faraz Khan1, Wasim Akhtar1, Mohammad Mumtaz Alam1, Lalit Mohan Nainwal1, Sumit Kumar Kaushik1, Mymoona Akhter1, Suhel Parvez2, Syed Misbahul Hasan3, Mohammad Shaquiquzzaman4.
Abstract
Morpholine, a six-membered heterocycle containing one nitrogen and one oxygen atom, is a moiety of great significance. It forms an important intermediate in many industrial and organic syntheses. Morpholine containing drugs are of high therapeutic value. Its wide array of pharmacological activity includes anti-diabetic, anti-emetic, growth stimulant, anti-depressant, bronchodilator and anticancer. Multi-drug resistance in cancer cases have emerged in the last few years and have led to the failure of many chemotherapeutic drugs. Newer treatment methods and drugs are being developed to overcome this problem. Target based drug discovery is an effective method to develop novel anticancer drugs. To develop newer drugs, previously reported work needs to be studied. Keeping this in mind, last five year's literature on morpholine used as anticancer agents has been reviewed and summarized in the paper herein.Entities:
Keywords: Anticancer; Heterocycle; Morpholine; Structure activity relationship (SAR); Targeted-therapy
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Year: 2019 PMID： 30776694 DOI： 10.1016/j.ejmech.2019.02.015
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514