Literature DB >> 31429450

Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation.

Sajal Sen1, Yue Li, Vincent Lynch, Kuppuswamy Arumugam, Jonathan L Sessler, Jonathan F Arambula.   

Abstract

We report the synthesis of a novel hydroxyl-functionalised heteroleptic bis-NHC gold(i) complex that permits conjugation to various amines via carbamate bond formation. The resulting derivatives were studied in vitro using cell proliferation assays and fluorescent microscopic imaging of human cancer cell lines.

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Year:  2019        PMID： 31429450      PMCID： PMC7039396          DOI： 10.1039/c9cc05635a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  39 in total

1.  A New Gold-Catalyzed C-C Bond Formation This work was supported by the Deutsche Forschungsgemeinschaft (Ha 1932/5-1, Ha 1932/6-1) and the Fonds der Chemischen Industrie. Gold salts were donated by Degussa-Hüls AG. A.S.K.H. is indebted to Prof. M. Göbel for laboratory space.

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Journal:  Angew Chem Int Ed Engl       Date:  2000-07-03       Impact factor: 15.336

2.  Coordination metallacycles of an achiral dendron self-assemble via metal-metal interaction to form luminescent superhelical fibers.

Authors:  M Enomoto; A Kishimura; T Aida
Journal:  J Am Chem Soc       Date:  2001-06-13       Impact factor: 15.419

Review 3.  Gold compounds as therapeutic agents for human diseases.

Authors:  Susan J Berners-Price; Aleksandra Filipovska
Journal:  Metallomics       Date:  2011-07-14       Impact factor: 4.526

Review 4.  Gold-catalyzed organic transformations.

Authors:  Zigang Li; Chad Brouwer; Chuan He
Journal:  Chem Rev       Date:  2008-07-10       Impact factor: 60.622

5.  Self-assembly of a neutral luminescent Au(12) cluster with D(2) symmetry.

Authors:  Qing-Fu Sun; Terence Kwok-Ming Lee; Pei-Zhou Li; Liao-Yuan Yao; Jing-Jing Huang; Jing Huang; Shu-Yan Yu; Yi-Zhi Li; Eddie Chung-Chin Cheng; Vivian Wing-Wah Yam
Journal:  Chem Commun (Camb)       Date:  2008-09-22       Impact factor: 6.222

Review 6.  Recent advances in gold-NHC complexes with biological properties.

Authors:  Malka Mora; M Concepción Gimeno; Renso Visbal
Journal:  Chem Soc Rev       Date:  2018-11-26       Impact factor: 54.564

7.  Targeted delivery of doxorubicin to mitochondria.

Authors:  Graham R Chamberlain; David V Tulumello; Shana O Kelley
Journal:  ACS Chem Biol       Date:  2013-04-23       Impact factor: 5.100

Review 8.  Therapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatment.

Authors:  Chi-Ming Che; Raymond Wai-Yin Sun
Journal:  Chem Commun (Camb)       Date:  2011-06-14       Impact factor: 6.222

9.  Widespread expression of thioredoxin and thioredoxin reductase in non-small cell lung carcinoma.

Authors:  Y Soini; K Kahlos; U Näpänkangas; R Kaarteenaho-Wiik; M Säily; P Koistinen; P Pääakkö; A Holmgren; V L Kinnula
Journal:  Clin Cancer Res       Date:  2001-06       Impact factor: 12.531

10.  Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells.

Authors:  Christine Marzano; Valentina Gandin; Alessandra Folda; Guido Scutari; Alberto Bindoli; Maria Pia Rigobello
Journal:  Free Radic Biol Med       Date:  2006-12-22       Impact factor: 7.376
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  2 in total

1.  Toward multifunctional anticancer therapeutics: post-synthetic carbonate functionalisation of asymmetric Au(i) bis-N-heterocyclic carbenes.

Authors:  Sajal Sen; Mark W Perrin; Adam C Sedgwick; Evie Y Dunsky; Vincent M Lynch; Xiao-Peng He; Jonathan L Sessler; Jonathan F Arambula
Journal:  Chem Commun (Camb)       Date:  2020-06-10       Impact factor: 6.222

2.  Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer.

Authors:  Sajal Sen; Stephanie Hufnagel; Esther Y Maier; Isaiah Aguilar; Jayaraman Selvakumar; Jennie E DeVore; Vincent M Lynch; Kuppuswamy Arumugam; Zhengrong Cui; Jonathan L Sessler; Jonathan F Arambula
Journal:  J Am Chem Soc       Date:  2020-11-25       Impact factor: 16.383
  2 in total

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