Literature DB >> 30775924

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells.

Deliang Shen1,2,3, Zhenhua Li2,3,4, Shiqi Hu2,3, Ke Huang2,3, Teng Su2,3, Hongxia Liang1,2,3, Feiran Liu2,3, Ke Cheng1,2,3.   

Abstract

Stem cell therapies have shown promise in treating acute and chronic ischemic heart disease. However, current therapies are limited by the low retention and poor integration of injected cells in the injured tissue. Taking advantage of the natural infarct-homing ability of platelets, we engineered CD34 antibody-linked platelets (P-CD34) to capture circulating CD34-positive endogenous stem cells and direct them to the injured heart. In vitro, P-CD34 could bind to damaged aortas and capture endogenous stem cells in whole blood. In a mouse model of acute myocardial infarction, P-CD34 accumulated in the injured heart after intravenous administration, leading to a concentration of endogenous CD34 stem cells in the injured heart for effective heart repair. This represents a new technology for endogenous stem cell therapy.

Entities:  

Keywords:  Myocardium infarction; antibodies; endogenous stem cells; platelets

Mesh：

Substances：

Year:  2019        PMID： 30775924      PMCID： PMC7025326          DOI： 10.1021/acs.nanolett.8b04970

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  22 in total

Review 1.  Body builder: from synthetic cells to engineered tissues.

Authors:  Shiqi Hu; Brenda M Ogle; Ke Cheng
Journal:  Curr Opin Cell Biol       Date:  2018-04-25       Impact factor: 8.382

2.  Engineering PD-1-Presenting Platelets for Cancer Immunotherapy.

Authors:  Xudong Zhang; Jinqiang Wang; Zhaowei Chen; Quanyin Hu; Chao Wang; Junjie Yan; Gianpietro Dotti; Peng Huang; Zhen Gu
Journal:  Nano Lett       Date:  2018-07-31       Impact factor: 11.189

Review 3.  Endothelial and cardiac progenitor cells for cardiovascular repair: A controversial paradigm in cell therapy.

Authors:  Vanessa Bianconi; Amirhossein Sahebkar; Petri Kovanen; Francesco Bagaglia; Biagio Ricciuti; Paolo Calabrò; Giuseppe Patti; Matteo Pirro
Journal:  Pharmacol Ther       Date:  2017-08-19       Impact factor: 12.310

Review 4.  Platelets and their biomimetics for regenerative medicine and cancer therapies.

Authors:  Zhenhua Li; Shiqi Hu; Ke Cheng
Journal:  J Mater Chem B       Date:  2018-10-22       Impact factor: 6.331

Review 5.  Stem-cell therapy for cardiac disease.

Authors:  Vincent F M Segers; Richard T Lee
Journal:  Nature       Date:  2008-02-21       Impact factor: 49.962

6.  Targeted repair of heart injury by stem cells fused with platelet nanovesicles.

Authors:  Junnan Tang; Teng Su; Ke Huang; Phuong-Uyen Dinh; Zegen Wang; Adam Vandergriff; Michael T Hensley; Jhon Cores; Tyler Allen; Taosheng Li; Erin Sproul; Emily Mihalko; Leonard J Lobo; Laura Ruterbories; Alex Lynch; Ashley Brown; Thomas G Caranasos; Deliang Shen; George A Stouffer; Zhen Gu; Jinying Zhang; Ke Cheng
Journal:  Nat Biomed Eng       Date:  2018-01-10       Impact factor: 25.671

7.  Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction.

Authors:  Teng Su; Ke Huang; Michael A Daniele; Michael Taylor Hensley; Ashlyn T Young; Junnan Tang; Tyler A Allen; Adam C Vandergriff; Patrick D Erb; Frances S Ligler; Ke Cheng
Journal:  ACS Appl Mater Interfaces       Date:  2018-09-19       Impact factor: 9.229

8.  Systemic delivery of bone marrow-derived mesenchymal stem cells to the infarcted myocardium: feasibility, cell migration, and body distribution.

Authors:  Israel M Barbash; Pierre Chouraqui; Jack Baron; Micha S Feinberg; Sharon Etzion; Ariel Tessone; Liron Miller; Esther Guetta; Dov Zipori; Laurence H Kedes; Robert A Kloner; Jonathan Leor
Journal:  Circulation       Date:  2003-08-04       Impact factor: 29.690

Review 9.  Concise Review: Mending a Broken Heart: The Evolution of Biological Therapeutics.

Authors:  Caressa Chen; Vittavat Termglinchan; Ioannis Karakikes
Journal:  Stem Cells       Date:  2017-03-16       Impact factor: 6.277

10.  Cardiac cell-integrated microneedle patch for treating myocardial infarction.

Authors:  Junnan Tang; Jinqiang Wang; Ke Huang; Yanqi Ye; Teng Su; Li Qiao; Michael Taylor Hensley; Thomas George Caranasos; Jinying Zhang; Zhen Gu; Ke Cheng
Journal:  Sci Adv       Date:  2018-11-28       Impact factor: 14.136
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  6 in total

1.  Chemical Engineering of Cell Therapy for Heart Diseases.

Authors:  Zhenhua Li; Shiqi Hu; Ke Cheng
Journal:  Acc Chem Res       Date:  2019-05-24       Impact factor: 22.384

2.  Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine.

Authors:  Zhenzhen Wang; Kristen D Popowski; Zhenhua Li; Dashuai Zhu; Blanca López de Juan Abad; Xianyun Wang; Mengrui Liu; Halle Lutz; Nicole De Naeyer; C Todd DeMarco; Thomas N Denny; Phuong-Uyen C Dinh; Ke Cheng
Journal:  Nat Biomed Eng       Date:  2022-07-04       Impact factor: 29.234

3.  Exosome and Biomimetic Nanoparticle Therapies for Cardiac Regenerative Medicine.

Authors:  Sydney J Stine; Kristen D Popowski; Teng Su; Ke Cheng
Journal:  Curr Stem Cell Res Ther       Date:  2020       Impact factor: 3.828

Review 4.  Engineering better stem cell therapies for treating heart diseases.

Authors:  Junlang Li; Shiqi Hu; Ke Cheng
Journal:  Ann Transl Med       Date:  2020-04

Review 5.  Potential application of biomimetic exosomes in cardiovascular disease: focused on ischemic heart disease.

Authors:  In Sook Kang; Kihwan Kwon
Journal:  BMB Rep       Date:  2022-01       Impact factor: 4.778

Review 6.  Nanotechnology in cardiac stem cell therapy: cell modulation, imaging and gene delivery.

Authors:  Elangovan Sarathkumar; Marina Victor; Jaivardhan A Menon; Kunnumpurathu Jibin; Suresh Padmini; Ramapurath S Jayasree
Journal:  RSC Adv       Date:  2021-10-26       Impact factor: 4.036
  6 in total

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