R Schuon1, B Mrevlje2, B Vollmar3, T Lenarz1, G Paasche1. 1. Department of Otorhinolaryngology,Hannover Medical School,Germany. 2. Trent Cardiac Centre,Nottingham University Hospital NHS Trust,UK. 3. Rudolf-Zenker-Institute for Experimental Surgery,Rostock Medical School,Germany.
Abstract
OBJECTIVES: The cause of Eustachian tube dysfunction often remains unclear. Therefore, this study aimed to examine the feasibility and possible diagnostic use of optical coherence tomography in the Eustachian tube ex vivo. METHODS: Two female blackface sheep cadaver heads were examined bilaterally. Three conditions of the Eustachian tube were investigated: closed (resting position), actively opened and stented. The findings were compared (and correlated) with segmented histological cross-sections. RESULTS: Intraluminal placement of the Eustachian tube with the optical coherence tomography catheter was performed without difficulty. Regarding the limited infiltration depth of optical coherence tomography, tissues can be differentiated. The localisation of the stent was accurate as was the lumen. CONCLUSION: The application of optical coherence tomography in the Eustachian tube under these experimental conditions is considered to be a feasible, rapid and non-invasive diagnostic method, with possible diagnostic value for determining the luminal shape and superficial lining tissue of the Eustachian tube.
OBJECTIVES: The cause of Eustachian tube dysfunction often remains unclear. Therefore, this study aimed to examine the feasibility and possible diagnostic use of optical coherence tomography in the Eustachian tube ex vivo. METHODS: Two female blackface sheep cadaver heads were examined bilaterally. Three conditions of the Eustachian tube were investigated: closed (resting position), actively opened and stented. The findings were compared (and correlated) with segmented histological cross-sections. RESULTS: Intraluminal placement of the Eustachian tube with the optical coherence tomography catheter was performed without difficulty. Regarding the limited infiltration depth of optical coherence tomography, tissues can be differentiated. The localisation of the stent was accurate as was the lumen. CONCLUSION: The application of optical coherence tomography in the Eustachian tube under these experimental conditions is considered to be a feasible, rapid and non-invasive diagnostic method, with possible diagnostic value for determining the luminal shape and superficial lining tissue of the Eustachian tube.
Authors: Jungeun Won; Guillermo L Monroy; Roshan I Dsouza; Darold R Spillman; Jonathan McJunkin; Ryan G Porter; Jindou Shi; Edita Aksamitiene; MaryEllen Sherwood; Lindsay Stiger; Stephen A Boppart Journal: Biosensors (Basel) Date: 2021-05-03