Susan Hasanpour-Heidari1, Abdolreza Fazel2, Shahryar Semnani1, Seyyed-Reza Khandoozi3, Taghi Amiriani1, SeyedMehdi Sedaghat4, Reza Hosseinpoor4, Ramin Azarhoush5, Mohammad Poorabbasi6, Mohammad Naeimi-Tabiei7, Gholamreza Roshandel8, Freddie Bray9, Elisabete Weiderpass10. 1. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran. 2. Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Omid Cancer Research Center, Omid Preventive and Health Promotion Center, Gorgan, Iran. 3. Cancer Research Center, Golestan University of Medical Sciences, Gorgan, Iran. 4. Deputy of Public Health, Golestan University of Medical Sciences, Gorgan, Iran. 5. Department of Pathology, 5Azar hospital, Golestan University of Medical Sciences, Gorgan, Iran. 6. Death registry unit, Deputy of Public Health, Golestan University of Medical Sciences, Gorgan, Iran. 7. Department of Hematology/Oncology, Sayyad Shirazi hospital, Golestan University of Medical Sciences, Gorgan, Iran. 8. Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address: roshandel@goums.ac.ir. 9. Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France. 10. Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, Oslo, Norway; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Genetic Epidemiology Group, Folkhälsan Research Center, Faculty of Medicine, Helsinki University, Helsinki, Finland; Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Abstract
INTRODUCTION: Colorectal cancer (CRC) is one of the most common cancers in the Golestan province, Northern Iran. The purpose of this study is to describe colorectal cancer incidence patterns and trends in the province 2004-2013. METHODS: Data on CRC cases were obtained from the Golestan Population-based Cancer Registry (GPCR). The GPCR is a high-quality cancer registry that collects data on primary cancers according to internationally accepted standard protocols. Age-standardized Incidence rates (ASR) were calculated and the 10-year trend quantified using the average annual percentage change (AAPC) from Joinpoint regressions. RESULTS: The overall ASR of CRC were higher in men (14.8 per 100,000 person-years) and the urban populations (35.4), relative to women (11.5) and the rural populations (17.1), respectively. The overall incidence rate was observed to significantly increase 2004-2013 in men (AAPC = 7.3; 95%CI: 2.9-11.8) and women (AAPC = 6.6; 95%CI: 2.7-10.6). The analysis also showed that urban areas (AAPC = 8.1; 95%CI: 2.4-14.1) had a relatively more rapid increase in rates compared to rural areas (AAPC = 6.9; 95%CI: 2.2-11.7). CONCLUSIONS: CRC incidence rates in Golestan have been rising during the most recent decade, with a higher incidence and more rapid increases among men and the urban populations. The underlying risk factors should be assessed in the context of developing CRC prevention interventions in Golestan.
INTRODUCTION:Colorectal cancer (CRC) is one of the most common cancers in the Golestan province, Northern Iran. The purpose of this study is to describe colorectal cancer incidence patterns and trends in the province 2004-2013. METHODS: Data on CRC cases were obtained from the Golestan Population-based Cancer Registry (GPCR). The GPCR is a high-quality cancer registry that collects data on primary cancers according to internationally accepted standard protocols. Age-standardized Incidence rates (ASR) were calculated and the 10-year trend quantified using the average annual percentage change (AAPC) from Joinpoint regressions. RESULTS: The overall ASR of CRC were higher in men (14.8 per 100,000 person-years) and the urban populations (35.4), relative to women (11.5) and the rural populations (17.1), respectively. The overall incidence rate was observed to significantly increase 2004-2013 in men (AAPC = 7.3; 95%CI: 2.9-11.8) and women (AAPC = 6.6; 95%CI: 2.7-10.6). The analysis also showed that urban areas (AAPC = 8.1; 95%CI: 2.4-14.1) had a relatively more rapid increase in rates compared to rural areas (AAPC = 6.9; 95%CI: 2.2-11.7). CONCLUSIONS: CRC incidence rates in Golestan have been rising during the most recent decade, with a higher incidence and more rapid increases among men and the urban populations. The underlying risk factors should be assessed in the context of developing CRC prevention interventions in Golestan.
Authors: Norah Alsadhan; Alaa Almaiman; Mar Pujades-Rodriguez; Cathy Brennan; Farag Shuweihdi; Sultana A Alhurishi; Robert M West Journal: BMC Med Res Methodol Date: 2022-05-19 Impact factor: 4.612