Literature DB >> 30747181

Mitochondria targeted and NADH triggered photodynamic activity of chloromethyl modified Ru(ii) complexes under hypoxic conditions.

Na Tian1, Weize Sun, Xusheng Guo, Jian Lu, Chao Li, Yuanjun Hou, Xuesong Wang, Qianxiong Zhou.   

Abstract

Three chloromethyl-modified Ru(ii) complexes were designed and synthesized as mitochondria targeting photosensitizers, which can generate carbon radicals in the presence of NADH under visible light irradiation, cause DNA cleavage and covalent binding in Ar-saturated solutions, and lead to apoptosis of human ovarian carcinoma SKOV-3 cells under hypoxic conditions (3% O2), demonstrating a new mode of type I mechanism to overcome the limitation of hypoxia in photodynamic therapy (PDT).

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Year:  2019        PMID： 30747181     DOI： 10.1039/c8cc09186b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  7 in total

1.  Self-Assembled Dual-Targeted Epirubicin-Hybrid Polydopamine Nanoparticles for Combined Chemo-Photothermal Therapy of Triple-Negative Breast Cancer.

Authors:  Xiang Li; Qian Zou; Jing Zhang; Peng Zhang; Xiong Zhou; Satya Siva Kishan Yalamarty; Xinli Liang; Yali Liu; Qin Zheng; Jianqing Gao
Journal:  Int J Nanomedicine       Date:  2020-09-11

2.  Photoredox catalysis may be a general mechanism in photodynamic therapy.

Authors:  Mingle Li; Yunjie Xu; Zhongji Pu; Tao Xiong; Haiqiao Huang; Saran Long; Subin Son; Le Yu; Nem Singh; Yunkang Tong; Jonathan L Sessler; Xiaojun Peng; Jong Seung Kim
Journal:  Proc Natl Acad Sci U S A       Date:  2022-08-15       Impact factor: 12.779

Review 3.  Recent advances in noble metal complex based photodynamic therapy.

Authors:  Yanping Wu; Shumeng Li; Yuncong Chen; Weijiang He; Zijian Guo
Journal:  Chem Sci       Date:  2022-04-01       Impact factor: 9.969

4.  Effect of intermittency factor on singlet oxygen and PGE2 formation in azulene-mediated photodynamic therapy: A preliminary study.

Authors:  Teerasak Damrongrungruang; Sujaree Phiphitaporn; Nuttakul Salacheep; Chonlada Sritragool; Aroon Teerakapong; Kittipitch Meesawat; Anan Kruesubthaworn; Chaiyapong Ruangsuwan; Wilawan Weera-Archakul
Journal:  Biochem Biophys Rep       Date:  2022-06-04

Review 5.  Fighting Hypoxia to Improve PDT.

Authors:  Ludivine Larue; Bauyrzhan Myrzakhmetov; Amina Ben-Mihoub; Albert Moussaron; Noémie Thomas; Philippe Arnoux; Francis Baros; Régis Vanderesse; Samir Acherar; Céline Frochot
Journal:  Pharmaceuticals (Basel)       Date:  2019-10-30

6.  Chloromethyl-modified Ru(ii) complexes enabling large pH jumps at low concentrations through photoinduced hydrolysis.

Authors:  Na Tian; Weize Sun; Yang Feng; Xusheng Guo; Jian Lu; Chao Li; Yuanjun Hou; Xuesong Wang; Qianxiong Zhou
Journal:  Chem Sci       Date:  2019-10-24       Impact factor: 9.825

Review 7.  Recent Progress in Mitochondria-Targeted Drug and Drug-Free Agents for Cancer Therapy.

Authors:  M T Jeena; Sangpil Kim; Seongeon Jin; Ja-Hyoung Ryu
Journal:  Cancers (Basel)       Date:  2019-12-18       Impact factor: 6.639
  7 in total

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