Lucy Bai1, Brita Arver2, Hemming Johansson3, Kerstin Sandelin4, Marie Wickman5, Yvonne Brandberg6. 1. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Bioclinicum J5:17, SE-171 64, Solna, Sweden. Electronic address: lucy.bai@ki.se. 2. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Bioclinicum J5:17, SE-171 64, Solna, Sweden. Electronic address: brita.arver@gmail.com. 3. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Bioclinicum J5:17, SE-171 64, Solna, Sweden. Electronic address: hemming.johansson@sll.se. 4. Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna (L1:00), SE-171 76, Stockholm, Sweden. Electronic address: kerstin.sandelin@ki.se. 5. Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Solna (L1:00), SE-171 76, Stockholm, Sweden; Sophiahemmet University, Stockholm, Sweden. Electronic address: marie.wickman@ki.se. 6. Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Bioclinicum J5:17, SE-171 64, Solna, Sweden. Electronic address: yvonne.brandberg@ki.se.
Abstract
PURPOSE: To prospectively follow-up and investigate women's perceptions of the cosmetic outcome of their implant-based breast reconstruction, body image, sexuality, anxiety/depressive symptoms, and health-related quality of life (HRQoL) 6-20 years after bilateral risk-reducing mastectomy (RRM), or complementary RRM after breast cancer diagnosis, due to increased risk of hereditary breast cancer. PATIENTS AND METHODS: Women with and without previous breast cancer diagnosis that underwent RRM between March 1997 and September 2010 were invited (n = 200). We compared 146 (73%) sets of long-term questionnaire responses (e.g., EORTC QLQ-BRR26, Body Image Scale, Sexuality Activity Questionnaire, Hospital Anxiety and Depression Scale, and SF-36) with responses one year after surgery. Women with and without previous breast cancer were compared at the long-term assessment point. RESULTS: The HRQoL and anxiety/depressive symptoms remained unchanged compared with one year after surgery, and there were no between-group differences. The negative impact on body image persisted in both groups for most of the items. 'Sexual discomfort' increased significantly for women with previous breast cancer (p = 0.016). Women with previous breast cancer also reported more problems with 'Disease treatment/surgery related symptoms' (p = 0.006) and 'Sexuality' (p = 0.031) in the EORTC QLQ-BRR26 questionnaire. CONCLUSION: Problems with body image appeared to persist long time post-RRM. No differences in HRQoL were found at the long-term follow-up between women with and without previous breast cancer. The results of this investigation might be of use in improving future counselling before risk-reducing surgery for women in the decision-making process.
PURPOSE: To prospectively follow-up and investigate women's perceptions of the cosmetic outcome of their implant-based breast reconstruction, body image, sexuality, anxiety/depressive symptoms, and health-related quality of life (HRQoL) 6-20 years after bilateral risk-reducing mastectomy (RRM), or complementary RRM after breast cancer diagnosis, due to increased risk of hereditary breast cancer. PATIENTS AND METHODS: Women with and without previous breast cancer diagnosis that underwent RRM between March 1997 and September 2010 were invited (n = 200). We compared 146 (73%) sets of long-term questionnaire responses (e.g., EORTC QLQ-BRR26, Body Image Scale, Sexuality Activity Questionnaire, Hospital Anxiety and Depression Scale, and SF-36) with responses one year after surgery. Women with and without previous breast cancer were compared at the long-term assessment point. RESULTS: The HRQoL and anxiety/depressive symptoms remained unchanged compared with one year after surgery, and there were no between-group differences. The negative impact on body image persisted in both groups for most of the items. 'Sexual discomfort' increased significantly for women with previous breast cancer (p = 0.016). Women with previous breast cancer also reported more problems with 'Disease treatment/surgery related symptoms' (p = 0.006) and 'Sexuality' (p = 0.031) in the EORTC QLQ-BRR26 questionnaire. CONCLUSION: Problems with body image appeared to persist long time post-RRM. No differences in HRQoL were found at the long-term follow-up between women with and without previous breast cancer. The results of this investigation might be of use in improving future counselling before risk-reducing surgery for women in the decision-making process.
Authors: Luciana Silveira Campos; Simone Pellin De Nardi; Leo Francisco Limberger; Jose Manoel Caldas Journal: Support Care Cancer Date: 2022-02-28 Impact factor: 3.603
Authors: Hilary Weingarden; Sabine Wilhelm; Jamie M Jacobs; Julia Carrellas; Curtis Cetrulo; William Gerald Austen; Amy S Colwell Journal: Body Image Date: 2022-06-09