Literature DB >> 30739483

Phagocytosis of monosodium urate crystals by human synoviocytes induces inflammation.

Yessica Zamudio-Cuevas1,2, Javier Fernández-Torres1,2, Gabriela Angélica Martínez-Nava1, Karina Martínez-Flores1, Adriana Ramírez Olvera1, Daniel Medina-Luna1, Alma Delia Hernández Pérez3, Carlos Landa-Solís4, Alberto López-Reyes1.   

Abstract

IMPACT STATEMENT: Gout is distinguished by an inflammatory process that is mediated by phagocytosis of monosodium urate (MSU) crystals in synoviocytes by regulation of unknown mechanisms. Here we suggest that the synovial cells play a crucial role in gouty arthritis by activating inflammation by MSU uptake and increasing the secretion of pro-inflammatory cytokines IL-1β, IL-6, IL-8, TNF-α, MCP-1, and the growth factors NGF and HGF. We discuss some co-existing features in synoviocytes, including anomalous morphologies of the cells, and microvesicle formation, dysregulation in VEGF gene expression. We provide evidence that phagocytosis of MSU crystals triggers an inflammatory cellular state in synoviocytes in the pathogenesis of crystal-induced arthritis.

Entities:  

Keywords:  gene; Cytokines; HIF-1α signaling pathway; gout; synoviocytes

Mesh：

Substances：

Year:  2019        PMID： 30739483      PMCID： PMC6488864          DOI： 10.1177/1535370219830665

Source DB:  PubMed          Journal:  Exp Biol Med (Maywood)        ISSN： 1535-3699


  44 in total

Review 1.  Mechanisms of inflammation in gout.

Authors:  N Dalbeth; D O Haskard
Journal:  Rheumatology (Oxford)       Date:  2005-06-14       Impact factor: 7.580

Review 2.  Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!

Authors:  T Gaber; R Dziurla; R Tripmacher; G R Burmester; F Buttgereit
Journal:  Ann Rheum Dis       Date:  2005-03-30       Impact factor: 19.103

3.  Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappaB and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines.

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4.  Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages.

Authors:  R Clive Landis; Darshna R Yagnik; Oliver Florey; Pandelis Philippidis; Vivien Emons; Justin C Mason; Dorian O Haskard
Journal:  Arthritis Rheum       Date:  2002-11

5.  Hepatocyte growth factor signalling stimulates hypoxia inducible factor-1 (HIF-1) activity in HepG2 hepatoma cells.

Authors:  L Tacchini; P Dansi; E Matteucci; M A Desiderio
Journal:  Carcinogenesis       Date:  2001-09       Impact factor: 4.944

6.  Gout-associated uric acid crystals activate the NALP3 inflammasome.

Authors:  Fabio Martinon; Virginie Pétrilli; Annick Mayor; Aubry Tardivel; Jürg Tschopp
Journal:  Nature       Date:  2006-01-11       Impact factor: 49.962

7.  Noninflammatory phagocytosis of monosodium urate monohydrate crystals by mouse macrophages. Implications for the control of joint inflammation in gout.

Authors:  D R Yagnik; P Hillyer; D Marshall; C D Smythe; T Krausz; D O Haskard; R C Landis
Journal:  Arthritis Rheum       Date:  2000-08

Review 8.  Osteoarthritis, angiogenesis and inflammation.

Authors:  C S Bonnet; D A Walsh
Journal:  Rheumatology (Oxford)       Date:  2004-08-03       Impact factor: 7.580

9.  NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.

Authors:  Shuichi Fujioka; Jiangong Niu; Christian Schmidt; Guido M Sclabas; Bailu Peng; Tadashi Uwagawa; Zhongkui Li; Douglas B Evans; James L Abbruzzese; Paul J Chiao
Journal:  Mol Cell Biol       Date:  2004-09       Impact factor: 4.272

10.  Elevated angiogenin levels in synovial fluid from patients with inflammatory arthritis and secretion of angiogenin by cultured synovial fibroblasts.

Authors:  F Lioté; R Champy; M Moenner; B Boval-Boizard; J Badet
Journal:  Clin Exp Immunol       Date:  2003-04       Impact factor: 4.330
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  6 in total

Review 1.  Potential Molecular Mechanisms of Plantain in the Treatment of Gout and Hyperuricemia Based on Network Pharmacology.

Authors:  Pei Liu; Huachong Xu; Yucong Shi; Li Deng; Xiaoyin Chen
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2.  Integrated Molecular Docking with Network Pharmacology to Reveal the Molecular Mechanism of Simiao Powder in the Treatment of Acute Gouty Arthritis.

Authors:  Yihua Fan; Wei Liu; Yue Jin; Xu Hou; Xuewu Zhang; Hudan Pan; Hang Lu; Xiaojing Guo
Journal:  Evid Based Complement Alternat Med       Date:  2021-04-27       Impact factor: 2.629

3.  Highly specific and label-free histological identification of microcrystals in fresh human gout tissues with stimulated Raman scattering.

Authors:  Bohan Zhang; Hanlin Xu; Jun Chen; Xiaoxia Zhu; Yu Xue; Yifan Yang; Jianpeng Ao; Yinghui Hua; Minbiao Ji
Journal:  Theranostics       Date:  2021-01-01       Impact factor: 11.556

4.  Profile of serum cytokine concentrations in patients with gouty arthritis.

Authors:  Tie Zhang; Guozhen Wang; Jing Zheng; Shirui Li; Jing Xu
Journal:  J Int Med Res       Date:  2021-11       Impact factor: 1.671

5.  Potential molecular mechanisms of Ermiao san in the treatment of hyperuricemia and gout based on network pharmacology with molecular docking.

Authors:  Yin-Hong Geng; Jia-Hui Yan; Liang Han; Zhe Chen; Sheng-Hao Tu; Lin-Qi Zhang; Chun-Dong Song; Feng-Yang Duan; Ya-Fei Liu
Journal:  Medicine (Baltimore)       Date:  2022-09-16       Impact factor: 1.817

6.  Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study.

Authors:  Ya-Sian Chang; Chien-Yu Lin; Fuu-Jen Tsai; Jan-Gowth Chang; Shun-Jen Chang; Ting-Yuan Liu; Chung-Ming Huang; Chin-Chun Chung; Yu-Chia Chen
Journal:  Arthritis Res Ther       Date:  2022-10-11       Impact factor: 5.606
  6 in total

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