Literature DB >> 15800008

Hypoxia inducible factor (HIF) in rheumatology: low O2! See what HIF can do!

T Gaber1, R Dziurla, R Tripmacher, G R Burmester, F Buttgereit.   

Abstract

Maintenance of oxygen homoeostasis is the basic principle in cell proliferation, differentiation, survival, and function in all higher organisms. The transcription factor, HIF (hypoxia inducible factor) has a central role in oxygen homoeostasis, and is indispensably linked to energy metabolism. Abnormally reduced oxygen concentrations leading to dysfunctional cell metabolism are found in rheumatoid arthritis and hence, knowledge of the molecular adaptive responses to hypoxia and the involvement of HIF in the pathogenesis of RA are interesting.

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Year:  2005        PMID： 15800008      PMCID： PMC1755583          DOI： 10.1136/ard.2004.031641

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  118 in total

1.  HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia.

Authors:  D M Stroka; T Burkhardt; I Desbaillets; R H Wenger; D A Neil; C Bauer; M Gassmann; D Candinas
Journal:  FASEB J       Date:  2001-11       Impact factor: 5.191

Review 2.  Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification.

Authors:  Len Neckers
Journal:  Curr Med Chem       Date:  2003-05       Impact factor: 4.530

3.  The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors:  P H Maxwell; M S Wiesener; G W Chang; S C Clifford; E C Vaux; M E Cockman; C C Wykoff; C W Pugh; E R Maher; P J Ratcliffe
Journal:  Nature       Date:  1999-05-20       Impact factor: 49.962

4.  Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation.

Authors:  Gisela D'Angelo; Eric Duplan; Paul Vigne; Christian Frelin
Journal:  J Biol Chem       Date:  2003-02-13       Impact factor: 5.157

5.  Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.

Authors:  J B Hogenesch; W K Chan; V H Jackiw; R C Brown; Y Z Gu; M Pray-Grant; G H Perdew; C A Bradfield
Journal:  J Biol Chem       Date:  1997-03-28       Impact factor: 5.157

6.  Defective brain development in mice lacking the Hif-1alpha gene in neural cells.

Authors:  Shuhei Tomita; Masaki Ueno; Masami Sakamoto; Yuki Kitahama; Masaaki Ueki; Nobuhiro Maekawa; Haruhiko Sakamoto; Max Gassmann; Ryoichiro Kageyama; Natsuo Ueda; Frank J Gonzalez; Yousuke Takahama
Journal:  Mol Cell Biol       Date:  2003-10       Impact factor: 4.272

7.  A hypothesis on the pathogenesis of rheumatoid and other non-specific synovitides. IV A. The possible intermediate role of local hypoxia and metabolic alterations.

Authors:  J Ahlqvist
Journal:  Med Hypotheses       Date:  1984-03       Impact factor: 1.538

8.  Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.

Authors:  Norihiko Takeda; Koji Maemura; Yasushi Imai; Tomohiro Harada; Daiji Kawanami; Takefumi Nojiri; Ichiro Manabe; Ryozo Nagai
Journal:  Circ Res       Date:  2004-06-10       Impact factor: 17.367

9.  Fibroblast-like synoviocytes support B-cell pseudoemperipolesis via a stromal cell-derived factor-1- and CD106 (VCAM-1)-dependent mechanism.

Authors:  J A Burger; N J Zvaifler; N Tsukada; G S Firestein; T J Kipps
Journal:  J Clin Invest       Date:  2001-02       Impact factor: 14.808

10.  Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1.

Authors:  Daniel J Ceradini; Anita R Kulkarni; Matthew J Callaghan; Oren M Tepper; Nicholas Bastidas; Mark E Kleinman; Jennifer M Capla; Robert D Galiano; Jamie P Levine; Geoffrey C Gurtner
Journal:  Nat Med       Date:  2004-07-04       Impact factor: 53.440
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  55 in total

1.  [Hypoxia is a key factor in the inflammatory milieu of rheumatic diseases].

Authors:  M Hahne; T Gaber; F Buttgereit
Journal:  Z Rheumatol       Date:  2012-01       Impact factor: 1.372

2.  Differential response to CoCl2-stimulated hypoxia on HIF-1α, VEGF, and MMP-2 expression in ligament cells.

Authors:  Yequan Wang; Zhenyu Tang; Ruyue Xue; Gurinder K Singh; Wanqian Liu; Yonggang Lv; Li Yang
Journal:  Mol Cell Biochem       Date:  2011-09-22       Impact factor: 3.396

3.  Rheumatoid arthritis synovial microenvironment induces metabolic and functional adaptations in dendritic cells.

Authors:  M Canavan; V Marzaioli; T McGarry; V Bhargava; S Nagpal; D J Veale; U Fearon
Journal:  Clin Exp Immunol       Date:  2020-07-15       Impact factor: 4.330

4.  Hypoxia-inducible factor activation in myeloid cells contributes to the development of liver fibrosis in cholestatic mice.

Authors:  Bryan L Copple; Sophia Kaska; Callie Wentling
Journal:  J Pharmacol Exp Ther       Date:  2012-01-23       Impact factor: 4.030

Review 5.  The vasculature in rheumatoid arthritis: cause or consequence?

Authors:  Ewa M Paleolog
Journal:  Int J Exp Pathol       Date:  2009-06       Impact factor: 1.925

6.  Immunologically restricted patients exhibit a pronounced inflammation and inadequate response to hypoxia in fracture hematomas.

Authors:  Paula Hoff; T Gaber; K Schmidt-Bleek; U Sentürk; C L Tran; K Blankenstein; S Lütkecosmann; J Bredahl; H J Schüler; P Simon; G Wassilew; F Unterhauser; G R Burmester; G Schmidmaier; C Perka; G N Duda; F Buttgereit
Journal:  Immunol Res       Date:  2011-10       Impact factor: 2.829

7.  Immunological characterization of the early human fracture hematoma.

Authors:  Paula Hoff; T Gaber; C Strehl; K Schmidt-Bleek; A Lang; D Huscher; G R Burmester; G Schmidmaier; C Perka; G N Duda; F Buttgereit
Journal:  Immunol Res       Date:  2016-12       Impact factor: 2.829

8.  Characterization of synovial tissue from arthritis patients: a proton magnetic resonance spectroscopic investigation.

Authors:  Carol A Hitchon; Hani S El-Gabalawy; Tedros Bezabeh
Journal:  Rheumatol Int       Date:  2009-01-28       Impact factor: 2.631

9.  Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor.

Authors:  Johanna Westra; Elisabeth Brouwer; Ingrid A M van Roosmalen; Berber Doornbos-van der Meer; Miek A van Leeuwen; Marcel D Posthumus; Cees G M Kallenberg
Journal:  BMC Musculoskelet Disord       Date:  2010-03-30       Impact factor: 2.362

10.  Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4.

Authors:  Helen J Knowles; Anne-Marie Cleton-Jansen; Eberhard Korsching; Nicholas A Athanasou
Journal:  FASEB J       Date:  2010-07-28       Impact factor: 5.191
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