Literature DB >> 30738572

Adjuvant and antigenic properties of Mycobacterium avium subsp. paratuberculosis on experimental autoimmune encephalomyelitis.

Davide Cossu1, Kazumasa Yokoyama2, Tamami Sakanishi3, Eiichi Momotani4, Nobutaka Hattori5.   

Abstract

Mycobacterium avium subsp. paratuberculosis (MAP), the causative agent of Johne's disease in ruminants, has been linked as a possible risk factor for human multiple sclerosis. In the current study we investigated the adjuvant effect of MAP on experimental autoimmune encephalomyelitis (EAE). Groups of C57BL/6 mice were actively immunized with myelin oligodendrocyte glycoprotein (MOG) 35-55 peptide emulsified in incomplete Freund's adjuvant modified containing heat-killed MAP (MIFA). MOG-MIFA immunized mice showed an early disease onset and more severe clinical scores in comparison with MOG-CFA immunized mice, demonstrating for the first time the adjuvant effect of MAP on EAE development.
Copyright © 2019 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Adjuvant; C57BL/6J mice; Experimental autoimmune encephalomyelitis; Mycobacterium avium subsp. paratuberculosis

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Year:  2019        PMID： 30738572     DOI： 10.1016/j.jneuroim.2019.01.013

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  6 in total

Review 1.  Mycobacterium paratuberculosis zoonosis is a One Health emergency.

Authors:  Coad Thomas Dow; Briana Lizet Alvarez
Journal:  Ecohealth       Date:  2022-06-02       Impact factor: 4.464

Review 2.  Infections, Vaccines and Autoimmunity: A Multiple Sclerosis Perspective.

Authors:  Dejan Jakimovski; Bianca Weinstock-Guttman; Murali Ramanathan; Michael G Dwyer; Robert Zivadinov
Journal:  Vaccines (Basel)       Date:  2020-01-28

3.  PtpA and PknG Proteins Secreted by Mycobacterium avium subsp. paratuberculosis are Recognized by Sera from Patients with Rheumatoid Arthritis: A Case-Control Study.

Authors:  Marco Bo; Gian Luca Erre; Horacio Bach; Yael N Slavin; Piera Angela Manchia; Giuseppe Passiu; Leonardo A Sechi
Journal:  J Inflamm Res       Date:  2019-12-03

4.  Association between Lipoprotein Levels and Humoral Reactivity to Mycobacterium avium subsp. paratuberculosis in Multiple Sclerosis, Type 1 Diabetes Mellitus and Rheumatoid Arthritis.

Authors:  Marco Bo; Giannina Arru; Magdalena Niegowska; Gian Luca Erre; Piera Angela Manchia; Leonardo A Sechi
Journal:  Microorganisms       Date:  2019-10-08

5.  Mycobacterium avium subsp. paratuberculosis and microbiome profile of patients in a referral gastrointestinal diseases centre in the Sudan.

Authors:  Wisal A Elmagzoub; Sanaa M Idris; Maha Isameldin; Nassir Arabi; Abdelmonem Abdo; Mustafa Ibrahim; Md Anik Ashfaq Khan; Franziska Tanneberger; Sahar M Bakhiet; Julius B Okuni; Lonzy Ojok; Ahmed A Gameel; Ahmed Abd El Wahed; Michaël Bekaert; Mohamed E Mukhtar; Ahmad Amanzada; Kamal H Eltom; ElSagad Eltayeb
Journal:  PLoS One       Date:  2022-04-05       Impact factor: 3.240

6.  Peripheral blood bovine lymphocytes and MAP show distinctly different proteome changes and immune pathways in host-pathogen interaction.

Authors:  Kristina J H Kleinwort; Stefanie M Hauck; Roxane L Degroote; Armin M Scholz; Christina Hölzel; Erwin P Maertlbauer; Cornelia Deeg
Journal:  PeerJ       Date:  2019-11-25       Impact factor: 2.984
  6 in total

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