Joanna Głogowska-Szeląg1. 1. Zakład Patofizjologii, Katedra Patofizjologii i Endokrynologii, Śląski Uniwersytet Medyczny, Zabrze, Polska.
Abstract
OBJECTIVE: Introduction: Osteoporosis is chronic metabolic disease of the bone-joint system and it is increase risk of bone fractures and mortality. The effect of postmenopausal hormonal changes can be the adipose tissue gain along. Osteoporosis and decreased BMD in women with menopause can be a result of the change of body mass. Previous studies have demonstrated protective effect of high values of BMI on the bone tissue, may be which protect against osteoporosis. The aim: The assessment of BMD in a connection with the body mass index BMI in women with postmenopausal osteoporosis. PATIENTS AND METHODS: Materials and methods: The researches have been conducted on 120 selected postmenopausal women who were diagnosed with osteoporosis after analysis of the risk factors and carrying out the bone densitometry test - DXA method. The patients were divided into three research groups each comprising with 40 persons, depending on the body mass index BMI.. The first group were postmenopausal women with osteoporosis and with the value of BMI 18-24.9,indicating normal range; second group were postmenopausal women with osteoporosis with the value of BMI 25-29.9,indicating overweight and the third group were postmenopausal women with osteoporosis with the value BMI 30-34.9, indicating obesity. RESULTS: Results: In the group of postmenopausal women with osteoporosis with a BMI value corresponding to obesity, the mean BMD was 0.82 g/cm2. In the overweight and normal body mass index group there were no statistically significant differences in the values obtained, which are 0.78 and 0.79 g/cm2, respectively. The correlation analysis showed a statistically significant positive relationship - the increase in BMI was accompanied by the increasing BMD in the entire study population. The T-score in the densitometric study in relation to BMD was the lowest in people with normal BMI and comparable in the overweight group, while the highest in obese women. CONCLUSION: Conclusions: Of the results of the research: postmenopausal women with osteoporosis confirmed the relationship that there are higher BMD values with increasis BMI values. From the other side owerweight and obesity may determine an intensification of osteoporosis in postmenopausal women.
OBJECTIVE: Introduction: Osteoporosis is chronic metabolic disease of the bone-joint system and it is increase risk of bone fractures and mortality. The effect of postmenopausal hormonal changes can be the adipose tissue gain along. Osteoporosis and decreased BMD in women with menopause can be a result of the change of body mass. Previous studies have demonstrated protective effect of high values of BMI on the bone tissue, may be which protect against osteoporosis. The aim: The assessment of BMD in a connection with the body mass index BMI in women with postmenopausal osteoporosis. PATIENTS AND METHODS: Materials and methods: The researches have been conducted on 120 selected postmenopausal women who were diagnosed with osteoporosis after analysis of the risk factors and carrying out the bone densitometry test - DXA method. The patients were divided into three research groups each comprising with 40 persons, depending on the body mass index BMI.. The first group were postmenopausal women with osteoporosis and with the value of BMI 18-24.9,indicating normal range; second group were postmenopausal women with osteoporosis with the value of BMI 25-29.9,indicating overweight and the third group were postmenopausal women with osteoporosis with the value BMI 30-34.9, indicating obesity. RESULTS: Results: In the group of postmenopausal women with osteoporosis with a BMI value corresponding to obesity, the mean BMD was 0.82 g/cm2. In the overweight and normal body mass index group there were no statistically significant differences in the values obtained, which are 0.78 and 0.79 g/cm2, respectively. The correlation analysis showed a statistically significant positive relationship - the increase in BMI was accompanied by the increasing BMD in the entire study population. The T-score in the densitometric study in relation to BMD was the lowest in people with normal BMI and comparable in the overweight group, while the highest in obesewomen. CONCLUSION: Conclusions: Of the results of the research: postmenopausal women with osteoporosis confirmed the relationship that there are higher BMD values with increasis BMI values. From the other side owerweight and obesity may determine an intensification of osteoporosis in postmenopausal women.