Ahmed Fayed1, Ahmed Soliman2, Mervat Naguib3, Mahmoud Soliman4, M Salaheldin5. 1. Nephrology Unit, Internal Medicine Department, School of Medicine, Cairo University, Cairo, Egypt. Dr.fayed@gmail.com. 2. Nephrology Unit, Internal Medicine Department, School of Medicine, Cairo University, Cairo, Egypt. 3. Endocrinology Unit, Internal Medicine Department, School of Medicine, Cairo University, Cairo, Egypt. 4. Gynecology and Obstetrics Department, Cairo University School of Medicine, Cairo University, Cairo, Egypt. 5. Urology Department, Cairo University School of Medicine, Cairo University, Cairo, Egypt.
Abstract
BACKGROUND: Women with chronic kidney disease commonly have menstrual irregularities and fertility abnormalities. Antimüllerian hormone (AMH) and antral follicle count (AFC) are well-recognized indicators of ovarian reserve. AIMS: To assess AMH level and total AFC in women who are on hemodialysis and after successful kidney transplantation (KTx). METHODS: Sixty women with end-stage kidney disease (ESKD) on regular hemodialysis were included in this study with 20 patients of them were going to have renal transplant. Fifty age-matched healthy females were enrolled as control. Serum AMH level was measured in all participants once and in transplant patients four times (before surgery, and at 1, 6, and 12 months after surgery). AFC was evaluated once in all subjects and in transplant patients twice (before and 1 year after surgery). RESULTS: ESKD patients had significantly lower AMH concentration and AFC than healthy controls (1.8 ± 1.2 vs. 3.5 ± 1.7 ng/ml, p < 0.001) and (12 ± 4.6 vs. 17.4 ± 4.3, p < 0.001), respectively. In the subgroup transplant patients, AMH level decreased significantly from (1.7 ± 1.3 ng/ml) before Ktx to (1.5 ± 1.2 ng/ml, p = 0.001) at 1 month, (1.1 ± 0.9 ng/ml, p < 0.001) at 6 months, (0.9 ± 0.8 ng/ml, p < 0.001) at 1 year after Ktx. Also, total AFC declined in transplant females from (11.1 ± 4.5) before KTx to (6.6 ± 3.4) after KTx (p < 0.001). CONCLUSIONS: Women with ESKD who are on hemodialysis have lower ovarian reserve than healthy females. Moreover, renal transplantation was associated with reduction in AMH level and AFC.
BACKGROUND:Women with chronic kidney disease commonly have menstrual irregularities and fertility abnormalities. Antimüllerian hormone (AMH) and antral follicle count (AFC) are well-recognized indicators of ovarian reserve. AIMS: To assess AMH level and total AFC in women who are on hemodialysis and after successful kidney transplantation (KTx). METHODS: Sixty women with end-stage kidney disease (ESKD) on regular hemodialysis were included in this study with 20 patients of them were going to have renal transplant. Fifty age-matched healthy females were enrolled as control. Serum AMH level was measured in all participants once and in transplant patients four times (before surgery, and at 1, 6, and 12 months after surgery). AFC was evaluated once in all subjects and in transplant patients twice (before and 1 year after surgery). RESULTS: ESKD patients had significantly lower AMH concentration and AFC than healthy controls (1.8 ± 1.2 vs. 3.5 ± 1.7 ng/ml, p < 0.001) and (12 ± 4.6 vs. 17.4 ± 4.3, p < 0.001), respectively. In the subgroup transplant patients, AMH level decreased significantly from (1.7 ± 1.3 ng/ml) before Ktx to (1.5 ± 1.2 ng/ml, p = 0.001) at 1 month, (1.1 ± 0.9 ng/ml, p < 0.001) at 6 months, (0.9 ± 0.8 ng/ml, p < 0.001) at 1 year after Ktx. Also, total AFC declined in transplant females from (11.1 ± 4.5) before KTx to (6.6 ± 3.4) after KTx (p < 0.001). CONCLUSIONS:Women with ESKD who are on hemodialysis have lower ovarian reserve than healthy females. Moreover, renal transplantation was associated with reduction in AMH level and AFC.
Authors: B Pietrzak; A Cyganek; Z Jabiry-Zieniewicz; K Bobrowska; M Durlik; L Paczek; P Kamiński Journal: Transplant Proc Date: 2006 Jan-Feb Impact factor: 1.066
Authors: M Lessan-Pezeshki; S Ghazizadeh; M R Khatami; M Mahdavi; E Razeghi; S Seifi; F Ahmadi; S Maziar Journal: Transplant Proc Date: 2004-06 Impact factor: 1.066