Literature DB >> 30735646

Unraveling Difficult Answers: From Genotype to Phenotype in Coronary Artery Disease.

Tarek Magdy1, Paul W Burridge2.   

Abstract

Genome-wide association studies (GWASs) have robustly found a correlation between coronary artery disease (CAD) and an intergenic region at locus 9p21.3. However, the mechanistic implication of this association is unknown. Recently in Cell, Lo Sardo et al. used hiPSC genome editing to demonstrate how this locus contributes to CAD predisposition.
Copyright © 2019 Elsevier Inc. All rights reserved.

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Year:  2019        PMID： 30735646      PMCID： PMC7375859          DOI： 10.1016/j.stem.2019.01.008

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

Review 1.  Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease.

Authors:  Matthew R Alexander; Gary K Owens
Journal:  Annu Rev Physiol       Date:  2011-10-10       Impact factor: 19.318

2.  PLINK: a tool set for whole-genome association and population-based linkage analyses.

Authors:  Shaun Purcell; Benjamin Neale; Kathe Todd-Brown; Lori Thomas; Manuel A R Ferreira; David Bender; Julian Maller; Pamela Sklar; Paul I W de Bakker; Mark J Daly; Pak C Sham
Journal:  Am J Hum Genet       Date:  2007-07-25       Impact factor: 11.025

3.  Heart disease and stroke statistics--2014 update: a report from the American Heart Association.

Authors:  Alan S Go; Dariush Mozaffarian; Véronique L Roger; Emelia J Benjamin; Jarett D Berry; Michael J Blaha; Shifan Dai; Earl S Ford; Caroline S Fox; Sheila Franco; Heather J Fullerton; Cathleen Gillespie; Susan M Hailpern; John A Heit; Virginia J Howard; Mark D Huffman; Suzanne E Judd; Brett M Kissela; Steven J Kittner; Daniel T Lackland; Judith H Lichtman; Lynda D Lisabeth; Rachel H Mackey; David J Magid; Gregory M Marcus; Ariane Marelli; David B Matchar; Darren K McGuire; Emile R Mohler; Claudia S Moy; Michael E Mussolino; Robert W Neumar; Graham Nichol; Dilip K Pandey; Nina P Paynter; Matthew J Reeves; Paul D Sorlie; Joel Stein; Amytis Towfighi; Tanya N Turan; Salim S Virani; Nathan D Wong; Daniel Woo; Melanie B Turner
Journal:  Circulation       Date:  2013-12-18       Impact factor: 29.690

4.  Chromosome 9p21 genetic variation explains 13% of cardiovascular disease incidence but does not improve risk prediction.

Authors:  K Gränsbo; P Almgren; M Sjögren; J G Smith; G Engström; B Hedblad; O Melander
Journal:  J Intern Med       Date:  2013-03-25       Impact factor: 8.989

Review 5.  Validating the pharmacogenomics of chemotherapy-induced cardiotoxicity: What is missing?

Authors:  Tarek Magdy; Brian T Burmeister; Paul W Burridge
Journal:  Pharmacol Ther       Date:  2016-09-05       Impact factor: 12.310

6.  Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing.

Authors:  Valentina Lo Sardo; Pavel Chubukov; William Ferguson; Aditya Kumar; Evan L Teng; Michael Duran; Lei Zhang; Gregory Cost; Adam J Engler; Fyodor Urnov; Eric J Topol; Ali Torkamani; Kristin K Baldwin
Journal:  Cell       Date:  2018-12-06       Impact factor: 41.582

7.  Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms.

Authors:  Joanna M M Howson; Wei Zhao; Daniel R Barnes; Weang-Kee Ho; Robin Young; Dirk S Paul; Lindsay L Waite; Daniel F Freitag; Eric B Fauman; Elias L Salfati; Benjamin B Sun; John D Eicher; Andrew D Johnson; Wayne H H Sheu; Sune F Nielsen; Wei-Yu Lin; Praveen Surendran; Anders Malarstig; Jemma B Wilk; Anne Tybjærg-Hansen; Katrine L Rasmussen; Pia R Kamstrup; Panos Deloukas; Jeanette Erdmann; Sekar Kathiresan; Nilesh J Samani; Heribert Schunkert; Hugh Watkins; Ron Do; Daniel J Rader; Julie A Johnson; Stanley L Hazen; Arshed A Quyyumi; John A Spertus; Carl J Pepine; Nora Franceschini; Anne Justice; Alex P Reiner; Steven Buyske; Lucia A Hindorff; Cara L Carty; Kari E North; Charles Kooperberg; Eric Boerwinkle; Kristin Young; Mariaelisa Graff; Ulrike Peters; Devin Absher; Chao A Hsiung; Wen-Jane Lee; Kent D Taylor; Ying-Hsiang Chen; I-Te Lee; Xiuqing Guo; Ren-Hua Chung; Yi-Jen Hung; Jerome I Rotter; Jyh-Ming J Juang; Thomas Quertermous; Tzung-Dau Wang; Asif Rasheed; Philippe Frossard; Dewan S Alam; Abdulla Al Shafi Majumder; Emanuele Di Angelantonio; Rajiv Chowdhury; Yii-Der Ida Chen; Børge G Nordestgaard; Themistocles L Assimes; John Danesh; Adam S Butterworth; Danish Saleheen
Journal:  Nat Genet       Date:  2017-05-22       Impact factor: 41.307

8.  Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Authors:  Dan E Arking; Sara L Pulit; Lia Crotti; Pim van der Harst; Patricia B Munroe; Tamara T Koopmann; Nona Sotoodehnia; Elizabeth J Rossin; Michael Morley; Xinchen Wang; Andrew D Johnson; Alicia Lundby; Daníel F Gudbjartsson; Peter A Noseworthy; Mark Eijgelsheim; Yuki Bradford; Kirill V Tarasov; Marcus Dörr; Martina Müller-Nurasyid; Annukka M Lahtinen; Ilja M Nolte; Albert Vernon Smith; Joshua C Bis; Aaron Isaacs; Stephen J Newhouse; Daniel S Evans; Wendy S Post; Daryl Waggott; Leo-Pekka Lyytikäinen; Andrew A Hicks; Lewin Eisele; David Ellinghaus; Caroline Hayward; Pau Navarro; Sheila Ulivi; Toshiko Tanaka; David J Tester; Stéphanie Chatel; Stefan Gustafsson; Meena Kumari; Richard W Morris; Åsa T Naluai; Sandosh Padmanabhan; Alexander Kluttig; Bernhard Strohmer; Andrie G Panayiotou; Maria Torres; Michael Knoflach; Jaroslav A Hubacek; Kamil Slowikowski; Soumya Raychaudhuri; Runjun D Kumar; Tamara B Harris; Lenore J Launer; Alan R Shuldiner; Alvaro Alonso; Joel S Bader; Georg Ehret; Hailiang Huang; W H Linda Kao; James B Strait; Peter W Macfarlane; Morris Brown; Mark J Caulfield; Nilesh J Samani; Florian Kronenberg; Johann Willeit; J Gustav Smith; Karin H Greiser; Henriette Meyer Zu Schwabedissen; Karl Werdan; Massimo Carella; Leopoldo Zelante; Susan R Heckbert; Bruce M Psaty; Jerome I Rotter; Ivana Kolcic; Ozren Polašek; Alan F Wright; Maura Griffin; Mark J Daly; David O Arnar; Hilma Hólm; Unnur Thorsteinsdottir; Joshua C Denny; Dan M Roden; Rebecca L Zuvich; Valur Emilsson; Andrew S Plump; Martin G Larson; Christopher J O'Donnell; Xiaoyan Yin; Marco Bobbo; Adamo P D'Adamo; Annamaria Iorio; Gianfranco Sinagra; Angel Carracedo; Steven R Cummings; Michael A Nalls; Antti Jula; Kimmo K Kontula; Annukka Marjamaa; Lasse Oikarinen; Markus Perola; Kimmo Porthan; Raimund Erbel; Per Hoffmann; Karl-Heinz Jöckel; Hagen Kälsch; Markus M Nöthen; Marcel den Hoed; Ruth J F Loos; Dag S Thelle; Christian Gieger; Thomas Meitinger; Siegfried Perz; Annette Peters; Hanna Prucha; Moritz F Sinner; Melanie Waldenberger; Rudolf A de Boer; Lude Franke; Pieter A van der Vleuten; Britt Maria Beckmann; Eimo Martens; Abdennasser Bardai; Nynke Hofman; Arthur A M Wilde; Elijah R Behr; Chrysoula Dalageorgou; John R Giudicessi; Argelia Medeiros-Domingo; Julien Barc; Florence Kyndt; Vincent Probst; Alice Ghidoni; Roberto Insolia; Robert M Hamilton; Stephen W Scherer; Jeffrey Brandimarto; Kenneth Margulies; Christine E Moravec; Fabiola del Greco M; Christian Fuchsberger; Jeffrey R O'Connell; Wai K Lee; Graham C M Watt; Harry Campbell; Sarah H Wild; Nour E El Mokhtari; Norbert Frey; Folkert W Asselbergs; Irene Mateo Leach; Gerjan Navis; Maarten P van den Berg; Dirk J van Veldhuisen; Manolis Kellis; Bouwe P Krijthe; Oscar H Franco; Albert Hofman; Jan A Kors; André G Uitterlinden; Jacqueline C M Witteman; Lyudmyla Kedenko; Claudia Lamina; Ben A Oostra; Gonçalo R Abecasis; Edward G Lakatta; Antonella Mulas; Marco Orrú; David Schlessinger; Manuela Uda; Marcello R P Markus; Uwe Völker; Harold Snieder; Timothy D Spector; Johan Ärnlöv; Lars Lind; Johan Sundström; Ann-Christine Syvänen; Mika Kivimaki; Mika Kähönen; Nina Mononen; Olli T Raitakari; Jorma S Viikari; Vera Adamkova; Stefan Kiechl; Maria Brion; Andrew N Nicolaides; Bernhard Paulweber; Johannes Haerting; Anna F Dominiczak; Fredrik Nyberg; Peter H Whincup; Aroon D Hingorani; Jean-Jacques Schott; Connie R Bezzina; Erik Ingelsson; Luigi Ferrucci; Paolo Gasparini; James F Wilson; Igor Rudan; Andre Franke; Thomas W Mühleisen; Peter P Pramstaller; Terho J Lehtimäki; Andrew D Paterson; Afshin Parsa; Yongmei Liu; Cornelia M van Duijn; David S Siscovick; Vilmundur Gudnason; Yalda Jamshidi; Veikko Salomaa; Stephan B Felix; Serena Sanna; Marylyn D Ritchie; Bruno H Stricker; Kari Stefansson; Laurie A Boyer; Thomas P Cappola; Jesper V Olsen; Kasper Lage; Peter J Schwartz; Stefan Kääb; Aravinda Chakravarti; Michael J Ackerman; Arne Pfeufer; Paul I W de Bakker; Christopher Newton-Cheh
Journal:  Nat Genet       Date:  2014-06-22       Impact factor: 38.330

9.  Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

Authors:  Evangelos Evangelou; Helen R Warren; David Mosen-Ansorena; Borbala Mifsud; Raha Pazoki; He Gao; Georgios Ntritsos; Niki Dimou; Claudia P Cabrera; Ibrahim Karaman; Fu Liang Ng; Marina Evangelou; Katarzyna Witkowska; Evan Tzanis; Jacklyn N Hellwege; Ayush Giri; Digna R Velez Edwards; Yan V Sun; Kelly Cho; J Michael Gaziano; Peter W F Wilson; Philip S Tsao; Csaba P Kovesdy; Tonu Esko; Reedik Mägi; Lili Milani; Peter Almgren; Thibaud Boutin; Stéphanie Debette; Jun Ding; Franco Giulianini; Elizabeth G Holliday; Anne U Jackson; Ruifang Li-Gao; Wei-Yu Lin; Jian'an Luan; Massimo Mangino; Christopher Oldmeadow; Bram Peter Prins; Yong Qian; Muralidharan Sargurupremraj; Nabi Shah; Praveen Surendran; Sébastien Thériault; Niek Verweij; Sara M Willems; Jing-Hua Zhao; Philippe Amouyel; John Connell; Renée de Mutsert; Alex S F Doney; Martin Farrall; Cristina Menni; Andrew D Morris; Raymond Noordam; Guillaume Paré; Neil R Poulter; Denis C Shields; Alice Stanton; Simon Thom; Gonçalo Abecasis; Najaf Amin; Dan E Arking; Kristin L Ayers; Caterina M Barbieri; Chiara Batini; Joshua C Bis; Tineka Blake; Murielle Bochud; Michael Boehnke; Eric Boerwinkle; Dorret I Boomsma; Erwin P Bottinger; Peter S Braund; Marco Brumat; Archie Campbell; Harry Campbell; Aravinda Chakravarti; John C Chambers; Ganesh Chauhan; Marina Ciullo; Massimiliano Cocca; Francis Collins; Heather J Cordell; Gail Davies; Martin H de Borst; Eco J de Geus; Ian J Deary; Joris Deelen; Fabiola Del Greco M; Cumhur Yusuf Demirkale; Marcus Dörr; Georg B Ehret; Roberto Elosua; Stefan Enroth; A Mesut Erzurumluoglu; Teresa Ferreira; Mattias Frånberg; Oscar H Franco; Ilaria Gandin; Paolo Gasparini; Vilmantas Giedraitis; Christian Gieger; Giorgia Girotto; Anuj Goel; Alan J Gow; Vilmundur Gudnason; Xiuqing Guo; Ulf Gyllensten; Anders Hamsten; Tamara B Harris; Sarah E Harris; Catharina A Hartman; Aki S Havulinna; Andrew A Hicks; Edith Hofer; Albert Hofman; Jouke-Jan Hottenga; Jennifer E Huffman; Shih-Jen Hwang; Erik Ingelsson; Alan James; Rick Jansen; Marjo-Riitta Jarvelin; Roby Joehanes; Åsa Johansson; Andrew D Johnson; Peter K Joshi; Pekka Jousilahti; J Wouter Jukema; Antti Jula; Mika Kähönen; Sekar Kathiresan; Bernard D Keavney; Kay-Tee Khaw; Paul Knekt; Joanne Knight; Ivana Kolcic; Jaspal S Kooner; Seppo Koskinen; Kati Kristiansson; Zoltan Kutalik; Maris Laan; Marty Larson; Lenore J Launer; Benjamin Lehne; Terho Lehtimäki; David C M Liewald; Li Lin; Lars Lind; Cecilia M Lindgren; YongMei Liu; Ruth J F Loos; Lorna M Lopez; Yingchang Lu; Leo-Pekka Lyytikäinen; Anubha Mahajan; Chrysovalanto Mamasoula; Jaume Marrugat; Jonathan Marten; Yuri Milaneschi; Anna Morgan; Andrew P Morris; Alanna C Morrison; Peter J Munson; Mike A Nalls; Priyanka Nandakumar; Christopher P Nelson; Teemu Niiranen; Ilja M Nolte; Teresa Nutile; Albertine J Oldehinkel; Ben A Oostra; Paul F O'Reilly; Elin Org; Sandosh Padmanabhan; Walter Palmas; Aarno Palotie; Alison Pattie; Brenda W J H Penninx; Markus Perola; Annette Peters; Ozren Polasek; Peter P Pramstaller; Quang Tri Nguyen; Olli T Raitakari; Meixia Ren; Rainer Rettig; Kenneth Rice; Paul M Ridker; Janina S Ried; Harriëtte Riese; Samuli Ripatti; Antonietta Robino; Lynda M Rose; Jerome I Rotter; Igor Rudan; Daniela Ruggiero; Yasaman Saba; Cinzia F Sala; Veikko Salomaa; Nilesh J Samani; Antti-Pekka Sarin; Reinhold Schmidt; Helena Schmidt; Nick Shrine; David Siscovick; Albert V Smith; Harold Snieder; Siim Sõber; Rossella Sorice; John M Starr; David J Stott; David P Strachan; Rona J Strawbridge; Johan Sundström; Morris A Swertz; Kent D Taylor; Alexander Teumer; Martin D Tobin; Maciej Tomaszewski; Daniela Toniolo; Michela Traglia; Stella Trompet; Jaakko Tuomilehto; Christophe Tzourio; André G Uitterlinden; Ahmad Vaez; Peter J van der Most; Cornelia M van Duijn; Anne-Claire Vergnaud; Germaine C Verwoert; Veronique Vitart; Uwe Völker; Peter Vollenweider; Dragana Vuckovic; Hugh Watkins; Sarah H Wild; Gonneke Willemsen; James F Wilson; Alan F Wright; Jie Yao; Tatijana Zemunik; Weihua Zhang; John R Attia; Adam S Butterworth; Daniel I Chasman; David Conen; Francesco Cucca; John Danesh; Caroline Hayward; Joanna M M Howson; Markku Laakso; Edward G Lakatta; Claudia Langenberg; Olle Melander; Dennis O Mook-Kanamori; Colin N A Palmer; Lorenz Risch; Robert A Scott; Rodney J Scott; Peter Sever; Tim D Spector; Pim van der Harst; Nicholas J Wareham; Eleftheria Zeggini; Daniel Levy; Patricia B Munroe; Christopher Newton-Cheh; Morris J Brown; Andres Metspalu; Adriana M Hung; Christopher J O'Donnell; Todd L Edwards; Bruce M Psaty; Ioanna Tzoulaki; Michael R Barnes; Louise V Wain; Paul Elliott; Mark J Caulfield
Journal:  Nat Genet       Date:  2018-09-17       Impact factor: 41.307

10.  A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.

Authors:  Majid Nikpay; Anuj Goel; Hong-Hee Won; Leanne M Hall; Christina Willenborg; Stavroula Kanoni; Danish Saleheen; Theodosios Kyriakou; Christopher P Nelson; Jemma C Hopewell; Thomas R Webb; Lingyao Zeng; Abbas Dehghan; Maris Alver; Sebastian M Armasu; Kirsi Auro; Andrew Bjonnes; Daniel I Chasman; Shufeng Chen; Ian Ford; Nora Franceschini; Christian Gieger; Christopher Grace; Stefan Gustafsson; Jie Huang; Shih-Jen Hwang; Yun Kyoung Kim; Marcus E Kleber; King Wai Lau; Xiangfeng Lu; Yingchang Lu; Leo-Pekka Lyytikäinen; Evelin Mihailov; Alanna C Morrison; Natalia Pervjakova; Liming Qu; Lynda M Rose; Elias Salfati; Richa Saxena; Markus Scholz; Albert V Smith; Emmi Tikkanen; Andre Uitterlinden; Xueli Yang; Weihua Zhang; Wei Zhao; Mariza de Andrade; Paul S de Vries; Natalie R van Zuydam; Sonia S Anand; Lars Bertram; Frank Beutner; George Dedoussis; Philippe Frossard; Dominique Gauguier; Alison H Goodall; Omri Gottesman; Marc Haber; Bok-Ghee Han; Jianfeng Huang; Shapour Jalilzadeh; Thorsten Kessler; Inke R König; Lars Lannfelt; Wolfgang Lieb; Lars Lind; Cecilia M Lindgren; Marja-Liisa Lokki; Patrik K Magnusson; Nadeem H Mallick; Narinder Mehra; Thomas Meitinger; Fazal-Ur-Rehman Memon; Andrew P Morris; Markku S Nieminen; Nancy L Pedersen; Annette Peters; Loukianos S Rallidis; Asif Rasheed; Maria Samuel; Svati H Shah; Juha Sinisalo; Kathleen E Stirrups; Stella Trompet; Laiyuan Wang; Khan S Zaman; Diego Ardissino; Eric Boerwinkle; Ingrid B Borecki; Erwin P Bottinger; Julie E Buring; John C Chambers; Rory Collins; L Adrienne Cupples; John Danesh; Ilja Demuth; Roberto Elosua; Stephen E Epstein; Tõnu Esko; Mary F Feitosa; Oscar H Franco; Maria Grazia Franzosi; Christopher B Granger; Dongfeng Gu; Vilmundur Gudnason; Alistair S Hall; Anders Hamsten; Tamara B Harris; Stanley L Hazen; Christian Hengstenberg; Albert Hofman; Erik Ingelsson; Carlos Iribarren; J Wouter Jukema; Pekka J Karhunen; Bong-Jo Kim; Jaspal S Kooner; Iftikhar J Kullo; Terho Lehtimäki; Ruth J F Loos; Olle Melander; Andres Metspalu; Winfried März; Colin N Palmer; Markus Perola; Thomas Quertermous; Daniel J Rader; Paul M Ridker; Samuli Ripatti; Robert Roberts; Veikko Salomaa; Dharambir K Sanghera; Stephen M Schwartz; Udo Seedorf; Alexandre F Stewart; David J Stott; Joachim Thiery; Pierre A Zalloua; Christopher J O'Donnell; Muredach P Reilly; Themistocles L Assimes; John R Thompson; Jeanette Erdmann; Robert Clarke; Hugh Watkins; Sekar Kathiresan; Ruth McPherson; Panos Deloukas; Heribert Schunkert; Nilesh J Samani; Martin Farrall
Journal:  Nat Genet       Date:  2015-09-07       Impact factor: 38.330
  10 in total
  4 in total

1.  Long Non-coding RNA ANRIL Downregulation Alleviates Neuroinflammation in an Ischemia Stroke Model via Modulation of the miR-671-5p/NF-κB Pathway.

Authors:  Ling Deng; Jin Jiang; Sha Chen; Xing Lin; Tianrui Zuo; Qingwen Hu; Yu Wu; Xiaomei Fan; Zhi Dong
Journal:  Neurochem Res       Date:  2022-03-31       Impact factor: 3.996

Review 2.  Use of hiPSC to explicate genomic predisposition to anthracycline-induced cardiotoxicity.

Authors:  Tarek Magdy; Paul W Burridge
Journal:  Pharmacogenomics       Date:  2021-01-15       Impact factor: 2.533

3.  Identification of Drug Transporter Genomic Variants and Inhibitors That Protect Against Doxorubicin-Induced Cardiotoxicity.

Authors:  Tarek Magdy; Mariam Jouni; Hui-Hsuan Kuo; Carly J Weddle; Davi Lyra-Leite; Hananeh Fonoudi; Marisol Romero-Tejeda; Mennat Gharib; Hoor Javed; Giovanni Fajardo; Colin J D Ross; Bruce C Carleton; Daniel Bernstein; Paul W Burridge
Journal:  Circulation       Date:  2021-12-07       Impact factor: 39.918

Review 4.  An Unanticipated Modulation of Cyclin-Dependent Kinase Inhibitors: The Role of Long Non-Coding RNAs.

Authors:  Debora Bencivenga; Emanuela Stampone; Angela Vastante; Myassar Barahmeh; Fulvio Della Ragione; Adriana Borriello
Journal:  Cells       Date:  2022-04-14       Impact factor: 7.666
  4 in total

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