Literature DB >> 30735051

Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii.

Hang Li1, Cameron L M Gilchrist1, Heather J Lacey2, Andrew Crombie2, Daniel Vuong2, John I Pitt3, Ernest Lacey2,4, Yit-Heng Chooi1, Andrew M Piggott4.   

Abstract

The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.

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Year:  2019        PMID： 30735051     DOI： 10.1021/acs.orglett.8b04042

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  9 in total

1.  Biosynthetic Cyclization Catalysts for the Assembly of Peptide and Polyketide Natural Products.

Authors:  Maria L Adrover-Castellano; Jennifer J Schmidt; David H Sherman
Journal:  ChemCatChem       Date:  2021-01-28       Impact factor: 5.686

2.  In the fungus where it happens: History and future propelling Aspergillus nidulans as the archetype of natural products research.

Authors:  Lindsay K Caesar; Neil L Kelleher; Nancy P Keller
Journal:  Fungal Genet Biol       Date:  2020-10-06       Impact factor: 3.495

3.  Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species.

Authors:  J Houbraken; S Kocsubé; C M Visagie; N Yilmaz; X-C Wang; M Meijer; B Kraak; V Hubka; K Bensch; R A Samson; J C Frisvad
Journal:  Stud Mycol       Date:  2020-06-27       Impact factor: 16.097

4.  Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis.

Authors:  Heather J Lacey; Cameron L M Gilchrist; Andrew Crombie; John A Kalaitzis; Daniel Vuong; Peter J Rutledge; Peter Turner; John I Pitt; Ernest Lacey; Yit-Heng Chooi; Andrew M Piggott
Journal:  Beilstein J Org Chem       Date:  2019-11-05       Impact factor: 2.883

Review 5.  A Decade of Antifungal Leads from Natural Products: 2010-2019.

Authors:  Mohammed Aldholmi; Pascal Marchand; Isabelle Ourliac-Garnier; Patrice Le Pape; A Ganesan
Journal:  Pharmaceuticals (Basel)       Date:  2019-12-12

6.  Synthaser: a CD-Search enabled Python toolkit for analysing domain architecture of fungal secondary metabolite megasynth(et)ases.

Authors:  Cameron L M Gilchrist; Yit-Heng Chooi
Journal:  Fungal Biol Biotechnol       Date:  2021-11-11

7.  In silico analyses of maleidride biosynthetic gene clusters.

Authors:  Katherine Williams; Kate M J de Mattos-Shipley; Christine L Willis; Andrew M Bailey
Journal:  Fungal Biol Biotechnol       Date:  2022-02-17

8.  Predicting the chemical space of fungal polyketides by phylogeny-based bioinformatics analysis of polyketide synthase-nonribosomal peptide synthetase and its modification enzymes.

Authors:  Atsushi Minami; Takahiro Ugai; Taro Ozaki; Hideaki Oikawa
Journal:  Sci Rep       Date:  2020-08-11       Impact factor: 4.379

9.  Traminines A and B, produced by Fusarium concentricum, inhibit oxidative phosphorylation in Saccharomyces cerevisiae mitochondria.

Authors:  Katsuyuki Sakai; Yufu Unten; Aoi Kimishima; Kenichi Nonaka; Takumi Chinen; Kazunari Sakai; Takeo Usui; Kazuro Shiomi; Masato Iwatsuki; Masatoshi Murai; Hideto Miyoshi; Yukihiro Asami; Satoshi Ōmura
Journal:  J Ind Microbiol Biotechnol       Date:  2021-12-23       Impact factor: 4.258
  9 in total

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