Hilde Haave1, Sahil Gulati2, Jorunn Brekke3, Stein Lybak1,4, Olav K Vintermyr4,5, Hans Jørgen Aarstad6,7. 1. a Department of ENT/Head and Neck Surgery , Haukeland University Hospital , Bergen , Norway. 2. b Department of ENT/Head and Neck surgery , Haukeland Universitetssjukehus , Bergen , Norway. 3. c Department of Oncology , Haukeland University Hospital , Bergen , Norway. 4. d Department of Clinical Medicine , University of Bergen , Bergen , Norway. 5. e Department of Pathology , Haukeland University Hospital , Bergen , Norway. 6. f Department of Clinical Medicine , University of Bergen, Haukeland University Hospital , Bergen , Norway. 7. g Deptartment of ENT/Head and Neck Surgery , Haukeland University Hospital , Bergen , Norway.
Abstract
BACKGROUND: Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide. AIMS/ OBJECTIVES: The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients. MATERIAL AND METHODS: Two hundred patients with OPSCC have been treated between 1992 and 2010. Histopathology slides from these patients have been morphologically evaluated in formalin-fixed, paraffin-embedded (FFPE) stained with hematoxylin-eosin (HE). From HE-stained sections tumor phenotype (keratinization, fraction of mature cancer cells and pattern of invasion) and tumor host responses (inflammation and stromal desmoplasia) were evaluated with respect to five years DSS. RESULTS: High tumor inflammatory response and low stromal desmoplasia had an independent effect predicting better five-year DSS among all patients and when analyzed separately in the HPV(-) and HPV(+) cohort of patients using a Cox regression survival analysis that also included standard clinical prognostic variables among OPSCC patients. CONCLUSION: Tumor host responses, inflammation and stromal desmoplasia may become part of routine work-up in OPSCC patients due to prognostic value. SIGNIFICANCE: We present a method, accessible in most clinical locations and would give important additional information about prognosis in OPSCC patients.
BACKGROUND: Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide. AIMS/ OBJECTIVES: The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients. MATERIAL AND METHODS: Two hundred patients with OPSCC have been treated between 1992 and 2010. Histopathology slides from these patients have been morphologically evaluated in formalin-fixed, paraffin-embedded (FFPE) stained with hematoxylin-eosin (HE). From HE-stained sections tumor phenotype (keratinization, fraction of mature cancer cells and pattern of invasion) and tumor host responses (inflammation and stromal desmoplasia) were evaluated with respect to five years DSS. RESULTS:High tumor inflammatory response and low stromal desmoplasia had an independent effect predicting better five-year DSS among all patients and when analyzed separately in the HPV(-) and HPV(+) cohort of patients using a Cox regression survival analysis that also included standard clinical prognostic variables among OPSCC patients. CONCLUSION:Tumor host responses, inflammation and stromal desmoplasia may become part of routine work-up in OPSCC patients due to prognostic value. SIGNIFICANCE: We present a method, accessible in most clinical locations and would give important additional information about prognosis in OPSCC patients.
Entities:
Keywords:
Head and neck; Neoplasms; fibroblasts; inflammation; oropharynx; prognosis
Authors: Xinyi Liu; Ping Liu; Rebecca D Chernock; Krystle A Lang Kuhs; James S Lewis; Jingqin Luo; Hiram A Gay; Wade L Thorstad; Xiaowei Wang Journal: EBioMedicine Date: 2020-10-07 Impact factor: 8.143
Authors: Harsh N Dongre; Hilde Haave; Siren Fromreide; Fredrik A Erland; Svein Erik Emblem Moe; Sophia Manueldas Dhayalan; Rasmus Kopperud Riis; Dipak Sapkota; Daniela Elena Costea; Hans Jorgen Aarstad; Olav K Vintermyr Journal: Front Oncol Date: 2021-09-24 Impact factor: 6.244