| Literature DB >> 30731359 |
Ishani Bhaumik1, Kunal Pal1, Utsab Debnath1, Parimal Karmakar2, Kuladip Jana1, Anup Kumar Misra3.
Abstract
A series of novel analogs of Allicin (S-allyl prop-2-ene-1-sulfinothioate) present in garlic has been synthesized in high yield. Synthesized 23 compounds were evaluated against different breast cancer cells (MDA-MB-468 and MCF-7) and non-cancer cells (WI38). Four compounds (3f, 3h, 3m and 3u) showed significant cytotoxicity against cancer cells whereas nontoxic to the normal cells. Based on the LD50 values and selectivity index (SI), compound 3h (S-p-methoxybenzyl (p-methoxyphenyl)methanesulfinothioate) was considered as most promising anticancer agent amongst the above three compounds. Further bio-chemical studies confirmed that compound 3h promotes ROS generation, changes in mitochondrial permeability transition and induced caspase mediated DNA damage and apoptosis.Entities:
Keywords: Allicin, garlic; Anti-cancer; Apoptosis; Caspase 3; ROS; Sulfenyl sulfoxide
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Year: 2019 PMID： 30731359 DOI： 10.1016/j.bioorg.2019.01.057
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275