Yunping Li1, Qi Wei2, Alan Le1, Bola Ayoub Gawargious3, Joseph L Demer4. 1. Stein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, USA. 2. Department of Bioengineering, George Mason University, Fairfax, Virginia, USA. 3. Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA. 4. Stein Eye Institute and Department of Ophthalmology, University of California, Los Angeles, Los Angeles, California, USA; Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, California, USA; Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, USA; Bioengineering Interdepartmental Program, University of California, Los Angeles, Los Angeles, California, USA. Electronic address: jld@jsei.ucla.edu.
Abstract
PURPOSE: To investigate the relationship between displacement of extraocular muscles (EOMs) and staphyloma in high myopia using magnetic resonance imaging (MRI). DESIGN: Retrospective case-control study. METHODS: Setting: Institutional study. POPULATION: Twenty-nine highly myopic patients (46 eyes), 11 age-matched healthy control subjects (21 eyes), and 34 patients (66 eyes) with sagging eye syndrome. PROCEDURES: MRI was analyzed for aspect ratio (AR) of the ocular cross section, locations of staphylomata and EOMs, and status of superior rectus to lateral rectus (SR-LR) band ligament. MAIN OUTCOME MEASURES: Association between staphylomata with EOM paths and the LR-SR band. RESULTS: Several associations of staphylomata were statistically significant (P < .05). Most staphylomata were superotemporal. Myopic patients with staphyloma had larger ARs in quasi-coronal images than in myopic subjects without staphyloma or normal controls. Compared to patients with high myopia without staphyloma and normal controls, when staphyloma was present, there was more inferior LR displacement, larger LR-globe angle, and larger SR-LR displacement angle than in myopic subjects without staphyloma. Staphyloma in the superotemporal quadrant was associated with greater SR-LR angle than in other quadrants. There were significantly more ruptures of SR-LR band ligament in highly myopic patients with staphyloma than in those without staphyloma. CONCLUSIONS: Local staphylomata in high myopia reflect ocular asphericity and correlate with EOM paths. Myopic staphylomata are associated with inferior displacement of LR path and defect of the LR-SR band ligament.
PURPOSE: To investigate the relationship between displacement of extraocular muscles (EOMs) and staphyloma in high myopia using magnetic resonance imaging (MRI). DESIGN: Retrospective case-control study. METHODS: Setting: Institutional study. POPULATION: Twenty-nine highly myopic patients (46 eyes), 11 age-matched healthy control subjects (21 eyes), and 34 patients (66 eyes) with sagging eye syndrome. PROCEDURES: MRI was analyzed for aspect ratio (AR) of the ocular cross section, locations of staphylomata and EOMs, and status of superior rectus to lateral rectus (SR-LR) band ligament. MAIN OUTCOME MEASURES: Association between staphylomata with EOM paths and the LR-SR band. RESULTS: Several associations of staphylomata were statistically significant (P < .05). Most staphylomata were superotemporal. Myopic patients with staphyloma had larger ARs in quasi-coronal images than in myopic subjects without staphyloma or normal controls. Compared to patients with high myopia without staphyloma and normal controls, when staphyloma was present, there was more inferior LR displacement, larger LR-globe angle, and larger SR-LR displacement angle than in myopic subjects without staphyloma. Staphyloma in the superotemporal quadrant was associated with greater SR-LR angle than in other quadrants. There were significantly more ruptures of SR-LR band ligament in highly myopic patients with staphyloma than in those without staphyloma. CONCLUSIONS: Local staphylomata in high myopia reflect ocular asphericity and correlate with EOM paths. Myopic staphylomata are associated with inferior displacement of LR path and defect of the LR-SR band ligament.
Authors: Preeti Gupta; Carol Y Cheung; Seang-Mei Saw; Mayuri Bhargava; Colin S Tan; Mellisa Tan; Adeline Yang; Frederick Tey; Gerard Nah; Paul Zhao; Tien Yin Wong; Ching-Yu Cheng Journal: Invest Ophthalmol Vis Sci Date: 2015-02-05 Impact factor: 4.799