Preeti Gupta1, Carol Y Cheung2, Seang-Mei Saw2, Mayuri Bhargava1, Colin S Tan3, Mellisa Tan4, Adeline Yang4, Frederick Tey4, Gerard Nah5, Paul Zhao5, Tien Yin Wong2, Ching-Yu Cheng2. 1. Singapore Eye Research Institute and Singapore National Eye Centre, Singapore Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore. 2. Singapore Eye Research Institute and Singapore National Eye Centre, Singapore. 3. National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore Fundus Image Reading Center, National Healthcare Group Eye Institute, Singapore. 4. DSO National Laboratories, Defence Medical and Environmental Research Institute, Singapore. 5. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore Vision Performance Centre, Military Medical Institute, Singapore Armed Forces, Singapore.
Abstract
PURPOSE: To describe the topography and predictors of peripapillary choroidal thickness (PPCT) in highly myopic eyes of young, healthy, Asian subjects. METHODS: A total of 870 young male subjects aged 21.63 ± 1.15 years were recruited from the Singapore military. Choroidal imaging was performed using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Peripapillary choroidal thickness was manually measured at eight locations around the optic disc. RESULTS: We analyzed 448 subjects with high myopia (defined as spherical equivalent [SE] worse than -6.0 diopters [D]) and 116 with emmetropia (SE > -0.5 and < 0.5 D). The mean SE was -8.52 ± 1.20 D for the high-myopic group, and 0.11 ± 0.24 D for the emmetropic group. The mean peripapillary choroid was significantly thinner (142.62 ± 43.84 μm) in high myopes compared with emmetropes (181.90 ± 46.43 μm, P < 0.001). Likewise, PPCT showed further decrease with increase in degree of myopic refractive error. Distribution of PPCT showed a markedly different pattern in high-myopic eyes (thickest superiorly) and emmetropic eyes (thickest temporally). However, peripapillary choroid in both the groups was thinnest at the inferior location. Among the ocular factors studied, axial length, IOP, presence of posterior staphyloma, and chorioretinal atrophy were the factors significantly associated with PPCT. CONCLUSIONS: Highly myopic eyes have significantly thinner peripapillary choroid and showed different distribution of thickness, compared with emmetropes. Axial length, IOP, and presence of posterior staphyloma and chorioretinal atrophy significantly influence PPCT and should be taken into consideration during clinical interpretation of PPCT measurement. Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
PURPOSE: To describe the topography and predictors of peripapillary choroidal thickness (PPCT) in highly myopic eyes of young, healthy, Asian subjects. METHODS: A total of 870 young male subjects aged 21.63 ± 1.15 years were recruited from the Singapore military. Choroidal imaging was performed using enhanced depth imaging (EDI) spectral-domain optical coherence tomography (SD-OCT). Peripapillary choroidal thickness was manually measured at eight locations around the optic disc. RESULTS: We analyzed 448 subjects with high myopia (defined as spherical equivalent [SE] worse than -6.0 diopters [D]) and 116 with emmetropia (SE > -0.5 and < 0.5 D). The mean SE was -8.52 ± 1.20 D for the high-myopic group, and 0.11 ± 0.24 D for the emmetropic group. The mean peripapillary choroid was significantly thinner (142.62 ± 43.84 μm) in high myopes compared with emmetropes (181.90 ± 46.43 μm, P < 0.001). Likewise, PPCT showed further decrease with increase in degree of myopic refractive error. Distribution of PPCT showed a markedly different pattern in high-myopic eyes (thickest superiorly) and emmetropic eyes (thickest temporally). However, peripapillary choroid in both the groups was thinnest at the inferior location. Among the ocular factors studied, axial length, IOP, presence of posterior staphyloma, and chorioretinal atrophy were the factors significantly associated with PPCT. CONCLUSIONS: Highly myopic eyes have significantly thinner peripapillary choroid and showed different distribution of thickness, compared with emmetropes. Axial length, IOP, and presence of posterior staphyloma and chorioretinal atrophy significantly influence PPCT and should be taken into consideration during clinical interpretation of PPCT measurement. Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
Authors: Rusdeep S Mundae; Linda M Zangwill; Sami W Kabbara; Naama Hammel; Christopher Bowd; Felipe A Medeiros; Christopher A Girkin; Jeffrey M Liebmann; Robert N Weinreb; Akram Belghith Journal: Am J Ophthalmol Date: 2017-12-19 Impact factor: 5.258
Authors: Jin Wook Jeoung; Hongli Yang; Stuart Gardiner; Ya Xing Wang; Seungwoo Hong; Brad Fortune; Michaël J A Girard; Christy Hardin; Ping Wei; Marcelo Nicolela; Jayme R Vianna; Balwantray C Chauhan; Claude F Burgoyne Journal: Am J Ophthalmol Date: 2020-05-21 Impact factor: 5.488