Angelina R Sutin1, Yannick Stephan2, Antonio Terracciano1. 1. Department of Behavioral Sciences and Social Medicine, Florida State University College of Medicine, Tallahassee, FL, USA. 2. EuroMov, University of Montpellier, Montpellier, France.
Abstract
OBJECTIVE: Verbal fluency is a common neuropsychological test that is impaired in dementia. We test whether verbal fluency is a prospective risk factor for incident dementia, cognitive impairment not dementia (CIND), and conversion from CIND to dementia. METHODS: Participants (N = 18 189) from the Health and Retirement Study were administered a standard test of verbal fluency and were assessed for cognitive status every 2 years between baseline and 6 years' follow-up. RESULTS: Every standard deviation increase in verbal fluency was associated with an approximately 60% reduced risk of incident dementia, an approximately 25% reduced risk of incident CIND, and an approximately 25% reduced risk of conversion from CIND to dementia. These associations were independent of age, gender, education, race, ethnicity, and APOE risk status. The associations were slightly weaker (but still significant) for African Americans and individuals with lower education. There was no interaction between verbal fluency and APOE risk status. CONCLUSION: Verbal fluency is an easily administered task that is predictive of incident cognitive impairment.
OBJECTIVE: Verbal fluency is a common neuropsychological test that is impaired in dementia. We test whether verbal fluency is a prospective risk factor for incident dementia, cognitive impairment not dementia (CIND), and conversion from CIND to dementia. METHODS:Participants (N = 18 189) from the Health and Retirement Study were administered a standard test of verbal fluency and were assessed for cognitive status every 2 years between baseline and 6 years' follow-up. RESULTS: Every standard deviation increase in verbal fluency was associated with an approximately 60% reduced risk of incident dementia, an approximately 25% reduced risk of incident CIND, and an approximately 25% reduced risk of conversion from CIND to dementia. These associations were independent of age, gender, education, race, ethnicity, and APOE risk status. The associations were slightly weaker (but still significant) for African Americans and individuals with lower education. There was no interaction between verbal fluency and APOE risk status. CONCLUSION: Verbal fluency is an easily administered task that is predictive of incident cognitive impairment.
Authors: Maurizio Gallucci; Maria Elena Di Battista; Giuseppe Battistella; Chiara Falcone; Patrizia Silvia Bisiacchi; Enrico Di Giorgi Journal: Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Date: 2017-07-18
Authors: A Solomon; F Mangialasche; E Richard; S Andrieu; D A Bennett; M Breteler; L Fratiglioni; B Hooshmand; A S Khachaturian; L S Schneider; I Skoog; M Kivipelto Journal: J Intern Med Date: 2014-03 Impact factor: 8.989
Authors: Antonio Terracciano; Angelina R Sutin; Yang An; Richard J O'Brien; Luigi Ferrucci; Alan B Zonderman; Susan M Resnick Journal: Alzheimers Dement Date: 2013-05-21 Impact factor: 21.566
Authors: Katrin Jekel; Marinella Damian; Carina Wattmo; Lucrezia Hausner; Roger Bullock; Peter J Connelly; Bruno Dubois; Maria Eriksdotter; Michael Ewers; Elmar Graessel; Milica G Kramberger; Emma Law; Patrizia Mecocci; José L Molinuevo; Louise Nygård; Marcel Gm Olde-Rikkert; Jean-Marc Orgogozo; Florence Pasquier; Karine Peres; Eric Salmon; Sietske Am Sikkes; Tomasz Sobow; René Spiegel; Magda Tsolaki; Bengt Winblad; Lutz Frölich Journal: Alzheimers Res Ther Date: 2015-03-18 Impact factor: 6.982
Authors: Angelina R Sutin; Yannick Stephan; Rodica Ioana Damian; Martina Luchetti; Jason E Strickhouser; Antonio Terracciano Journal: Psychol Aging Date: 2019-05
Authors: Jihyun Yang; Katie L McMahon; David A Copland; Dana Pourzinal; Gerard J Byrne; Anthony J Angwin; John D O'Sullivan; Nadeeka N Dissanayaka Journal: Brain Imaging Behav Date: 2022-07-16 Impact factor: 3.224
Authors: Angelina R Sutin; Martina Luchetti; Yannick Stephan; Jason E Strickhouser; Antonio Terracciano Journal: Int Psychogeriatr Date: 2021-02-22 Impact factor: 7.191
Authors: Carmen Moret-Tatay; Isabel Iborra-Marmolejo; María José Jorques-Infante; José Vicente Esteve-Rodrigo; Carla H A Schwanke; Tatiana Q Irigaray Journal: Medicina (Kaunas) Date: 2021-11-29 Impact factor: 2.430